公开(公告)号：EP2814840A1

公开(公告)日：2014-12-24

申请号：EP12868427.1

申请日：2012-07-11

申请人： Amunix Operating Inc. ,  Biogen Idec MA Inc.

发明人： SCHELLENBERGER, Volker ,  CHANG, Pei-yun ,  VARFAJ, Fatbardha ,  DING, Sheng ,  SILVERMAN, Joshua ,  WANG, Chia-wei ,  SPINK, Benjamin ,  STEMMER, Willem, P. ,  GEETHING, Nathan ,  KULMAN, John ,  LIU, Tongyao ,  TOBY, Garabet, G. ,  JIANG, Haiyan ,  PETERS, Robert ,  WANG, Deping ,  MEI, Baisong

IPC分类号： C07K14/755 ,  A61K38/37

摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.