公开(公告)号：EP2814840A1

公开(公告)日：2014-12-24

申请号：EP12868427.1

申请日：2012-07-11

申请人： Amunix Operating Inc. ,  Biogen Idec MA Inc.

发明人： SCHELLENBERGER, Volker ,  CHANG, Pei-yun ,  VARFAJ, Fatbardha ,  DING, Sheng ,  SILVERMAN, Joshua ,  WANG, Chia-wei ,  SPINK, Benjamin ,  STEMMER, Willem, P. ,  GEETHING, Nathan ,  KULMAN, John ,  LIU, Tongyao ,  TOBY, Garabet, G. ,  JIANG, Haiyan ,  PETERS, Robert ,  WANG, Deping ,  MEI, Baisong

IPC分类号： C07K14/755 ,  A61K38/37

摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

公开(公告)号：EP2802668A1

公开(公告)日：2014-11-19

申请号：EP13735995.6

申请日：2013-01-12

申请人： Biogen Idec MA Inc. ,  Puget Sound Blood Center

发明人： JIANG, Haiyan ,  LIU, Tongyao ,  KRISHNAMOORTHY, Sriram ,  JOSEPHSON, Neil ,  GLENN, Pierce

IPC分类号： C12P21/04

CPC分类号： A61K47/48415 ,  A61K38/21 ,  A61K38/37 ,  A61K39/0008 ,  A61K47/6811 ,  A61K47/6815 ,  A61K2039/6031 ,  A61K2039/6056 ,  C07K14/755 ,  C07K2319/30 ,  C12Q1/6883 ,  C12Q2600/156 ,  A61K2300/00

摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.

公开(公告)号：EP2804623A1

公开(公告)日：2014-11-26

申请号：EP13735649.9

申请日：2013-01-12

申请人： Biogen Idec MA Inc.

发明人： CHHABRA, Ekta, Seth ,  LIU, Tongyao ,  PETERS, Robert ,  JIANG, Haiyan

IPC分类号： A61K38/37

CPC分类号： C07K14/755 ,  A61K38/37 ,  A61K47/62 ,  C07K16/00 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/31

摘要： The present invention provides a VWF fragment comprising the D' domain and D3 domain of VWF, a chimeric protein comprising the VWF fragment and a heterologous moiety, or a chimeric protein comprising the VWF fragment and a FVIII protein and methods of using the same. A polypeptide chain comprising a VWF fragment of the invention binds to or is associated with a polypeptide chain comprising a FVIII protein and the polypeptide chain comprising the VWF fragment can prevent or inhibit binding of endogenous VWF to the FVIII protein. By preventing or inhibiting binding of endogenous VWF to the FVIII, which is a half-life limiting factor for FVIII, the VWF fragment can induce extension of half-life of the FVIII protein. The invention also includes nucleotides, vectors, host cells, methods of using the VWF fragment, or the chimeric proteins.

公开(公告)号：EP3033097A2

公开(公告)日：2016-06-22

申请号：EP14835828.6

申请日：2014-08-14

申请人： Biogen MA Inc. ,  Amunix Operating Inc.

发明人： LIU, Tongyao ,  CHANG, Pei-Yun ,  KULMAN, John ,  SCHELLENBERGER, Volker ,  JIANG, Haiyan ,  PETERS, Robert, T. ,  CHHABRA, Ekta, Seth

IPC分类号： A61K38/36 ,  A61K38/37 ,  A61K35/14 ,  C07K1/00 ,  C07K14/745 ,  C07K14/755

CPC分类号： A61K38/37 ,  A61K9/0019 ,  A61K38/00 ,  C07K14/00 ,  C07K14/755 ,  C07K2319/31

摘要： The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.

摘要翻译： 本发明提供了包含因子VIII（FVIII）多肽和XTEN多肽的嵌合蛋白质。 FVIII多肽可以对血管性血友病因子（VWF）具有降低的亲和力。 适当大小的XTEN多肽在特定位置插入到FVIII多肽中，以延长FVIII多肽的半衰期。 本发明还包括核苷酸，载体，宿主细胞和使用嵌合蛋白的方法，例如治疗出血疾病和病症。