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公开(公告)号：EP2814840A1
公开(公告)日：2014-12-24
申请号：EP12868427.1
申请日：2012-07-11
发明人： SCHELLENBERGER, Volker , CHANG, Pei-yun , VARFAJ, Fatbardha , DING, Sheng , SILVERMAN, Joshua , WANG, Chia-wei , SPINK, Benjamin , STEMMER, Willem, P. , GEETHING, Nathan , KULMAN, John , LIU, Tongyao , TOBY, Garabet, G. , JIANG, Haiyan , PETERS, Robert , WANG, Deping , MEI, Baisong
IPC分类号： C07K14/755 , A61K38/37
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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公开(公告)号：EP2440241B1
公开(公告)日：2017-08-09
申请号：EP10786725.1
申请日：2010-06-08
发明人： SCHELLENBERGER, Volker , SILVERMAN, Joshua , STEMMER, Willem, P. , WANG, Chia-Wei , GEETHING, Nathan , CLELAND, Jeffrey. L. , SPINK, Benjamin
IPC分类号： A61K38/48 , C07K14/46 , C12N9/64 , C07K14/61 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , A61P3/10 , A61P3/04 , A61P3/08 , C12N15/62 , A61K38/27
CPC分类号： C07K14/61 , A61K9/0019 , A61K38/00 , C07K2319/31 , C07K2319/35
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公开(公告)号：EP2393828A1
公开(公告)日：2011-12-14
申请号：EP10739085.8
申请日：2010-02-03
发明人： SCHELLENBERGER, Volker , SILVERMAN, Joshua , WANG, Chia-wei , SPINK, Benjamin , STEMMER, Willem, P. , GEETHING, Nathan , TO, Wayne , CLELAND, Jeffrey, L.
CPC分类号： C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
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公开(公告)号：EP2440241A1
公开(公告)日：2012-04-18
申请号：EP10786725.1
申请日：2010-06-08
发明人： SCHELLENBERGER, Volker , SILVERMAN, Joshua , STEMMER, Willem, P. , WANG, Chia-Wei , GEETHING, Nathan , CLELAND, Jeffrey. L.
IPC分类号： A61K38/48 , C07K14/46 , C12N9/64 , C07K14/61 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , A61P3/10 , A61P3/04 , A61P3/08
CPC分类号： C07K14/61 , A61K9/0019 , A61K38/00 , C07K2319/31 , C07K2319/35
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公开(公告)号：EP2393828B1
公开(公告)日：2016-10-12
申请号：EP10739085.8
申请日：2010-02-03
发明人： SCHELLENBERGER, Volker , SILVERMAN, Joshua , WANG, Chia-wei , SPINK, Benjamin , STEMMER, Willem, P. , GEETHING, Nathan , TO, Wayne , CLELAND, Jeffrey, L.
IPC分类号： C07K1/00 , C07K17/00 , C07K14/00 , C07K14/715 , C07K14/47 , C12N15/62 , C07K14/605 , C07K14/61 , C07K14/545 , C07K14/58 , C07K14/50 , A61K38/26 , A61K38/22 , A61K38/36 , A61K38/19 , C07K14/745
CPC分类号： C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
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公开(公告)号：EP2440228A1
公开(公告)日：2012-04-18
申请号：EP10786730.1
申请日：2010-06-08
发明人： SCHELLENBERGER, Volker , SILVERMAN, Joshua , STEMMER, Willem, P. , WANG, Chia-wei , GEETHING, Nathan , CLELAND, Jeffrey. L.
IPC分类号： A61K38/00
CPC分类号： C07K14/605 , A23V2200/328 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N15/70 , C12P21/02 , Y10S514/866
摘要： The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.
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公开(公告)号：EP2440228B1
公开(公告)日：2018-09-26
申请号：EP10786730.1
申请日：2010-06-08
发明人： SCHELLENBERGER, Volker , SILVERMAN, Joshua , STEMMER, Willem, P. , WANG, Chia-wei , GEETHING, Nathan , CLELAND, Jeffrey. L. , SPINK, Benjamin
IPC分类号： A61K38/22 , C07K14/46 , C07K14/61 , C12N15/63 , C12N1/21 , C12N5/10 , A61P3/10 , A61P3/04 , A61P3/08 , C12N15/62 , A61K38/27 , C07K14/575 , C07K14/605
CPC分类号： C07K14/605 , A23V2200/328 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N15/70 , C12P21/02 , Y10S514/866
摘要： The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.
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公开(公告)号：EP1996220B1
公开(公告)日：2013-05-08
申请号：EP07752636.6
申请日：2007-03-06
发明人： SCHELLENBERGER, Volker , STEMMER, Willem, P. , WANG, Chia-wei , SCHOLLE, Michael, D. , POPKOV, Mikhail , GORDON, Nathaniel, C. , CRAMERI, Andreas
CPC分类号： C12N15/1037 , A61K38/16 , C12N15/1044
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9.发明公开BINDING FUSION PROTEINS, BINDING FUSION PROTEIN-DRUG CONJUGATES, XTEN-DRUG CONJUGATES AND METHODS OF MAKING AND USING SAME 审中-公开结合蛋白融合，融合蛋白结合药物结合物，XTEN偶联药物和方法的生产和使用
公开(公告)号：EP2552967A2
公开(公告)日：2013-02-06
申请号：EP11763532.6
申请日：2011-04-01
发明人： SCHELLENBERGER, Volker , SILVERMAN, Joshua , WANG, Chia-wei , SPINK, Benjamin , STEMMER, Willem, P. , ALTERS, Susan E.
IPC分类号： C07K19/00
CPC分类号： C07K16/28 , C07K2317/622 , C07K2317/90 , C07K2319/01
摘要： The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
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