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公开(公告)号：EP1976502B1
公开(公告)日：2011-08-03
申请号：EP06846858.6
申请日：2006-12-29
IPC分类号： A61K31/192 , A61K31/436 , A61P25/04 , A61P9/10
CPC分类号： A61K31/192 , A61K31/436
摘要： The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.
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公开(公告)号：EP1910837A2
公开(公告)日：2008-04-16
申请号：EP06786341.5
申请日：2006-07-03
IPC分类号： G01N33/569 , C07K5/10 , C07K7/06 , C07K14/085 , C07K16/10 , A61K38/00 , A61K39/00 , A61P31/16
CPC分类号： A61K38/07 , A61K38/08 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K7/06 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2500/02
摘要： The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.
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公开(公告)号：EP1910837B1
公开(公告)日：2012-03-14
申请号：EP06786341.5
申请日：2006-07-03
IPC分类号： G01N33/569 , C07K5/10 , C07K7/06 , C07K14/085 , C07K16/10 , A61K38/00 , A61K39/00 , A61P31/16
CPC分类号： A61K38/07 , A61K38/08 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K7/06 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2500/02
摘要： The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.
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公开(公告)号：EP1976502A1
公开(公告)日：2008-10-08
申请号：EP06846858.6
申请日：2006-12-29
IPC分类号： A61K31/192 , A61K31/436 , A61P25/04 , A61P9/10
CPC分类号： A61K31/192 , A61K31/436
摘要： The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.
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公开(公告)号：EP2334315A2
公开(公告)日：2011-06-22
申请号：EP09812187.4
申请日：2009-09-02
申请人： Arbor Vita Corporation , Nono, Inc.
发明人： BELMARES, Michael P. , GARMAN, J. David , LU, Peter S. , SALTER, Michael W. , TYMIANSKI, Michael
IPC分类号： A61K38/00
摘要： The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat-NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS.
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