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公开(公告)号：EP1922307B1
公开(公告)日：2011-12-28
申请号：EP06836069.2
申请日：2006-05-17
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
IPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/85 , A61K31/501 , A61P35/00
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1922307A2
公开(公告)日：2008-05-21
申请号：EP06836069.2
申请日：2006-05-17
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
IPC分类号： C07D213/84 , C07D213/63 , A61K31/44
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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3.发明公开PROCESS FOR THE PREPARATION OF PYRAZOLYLAMINOQUINAZOLINE DERIVATIVES COMPRISING A PHOSPHATE GROUP 有权包含磷酸酯基团的吡唑基氨基喹唑啉衍生物的制备方法
公开(公告)号：EP2019832A1
公开(公告)日：2009-02-04
申请号：EP07732773.2
申请日：2007-05-14
申请人： AstraZeneca AB
IPC分类号： C07F9/02
CPC分类号： C07F9/65583 , Y02P20/55
摘要： The invention relates to a new process useful in the preparation of pharmaceutical compounds such as 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate (AZD1152) and intermediates used therein.
摘要翻译： 本发明涉及可用于制备药物化合物例如2- {乙基[3 - （{4 - [（5- {2 - [（3-氟苯基）氨基] -2-氧代乙基} 吡唑-3-基）氨基]喹唑啉-7-基}氧基）丙基]氨基}乙基磷酸二氢酯（AZD1152）及其中使用的中间体。
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4.发明授权PROCESS FOR THE PREPARATION OF PYRAZOLYLAMINOQUINAZOLINE DERIVATIVES COMPRISING A PHOSPHATE GROUP 有权包含磷酸酯基团的吡唑基氨基喹唑啉衍生物的制备方法
公开(公告)号：EP2019832B1
公开(公告)日：2012-09-12
申请号：EP07732773.2
申请日：2007-05-14
申请人： AstraZeneca AB
IPC分类号： C07F9/02
CPC分类号： C07F9/65583 , Y02P20/55
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公开(公告)号：EP1943240B1
公开(公告)日：2009-11-11
申请号：EP06794582.4
申请日：2006-09-27
申请人： AstraZeneca AB
发明人： BLIXT, Jörgen , GOLDEN, Michael, David , HOGAN, Philip, John , MARTIN, David, Michael, Glanville , MONTGOMERY, Francis, Joseph , PATEL, Zakariya , PITTAM, John, David , SEPENDA, George, Joseph , SQUIRE, Christopher, John , WRIGHT, Nicholas, Cartwright, Alexander
IPC分类号： C07D401/12 , C07D239/94 , C07D211/16
CPC分类号： C07D401/12 , C07D211/16 , C07D239/94
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6.发明授权
公开(公告)号：EP0904400B1
公开(公告)日：2005-03-16
申请号：EP97915612.2
申请日：1997-04-07
申请人： AstraZeneca AB
IPC分类号： C12P41/00 , C12P13/02 , C12P7/42 , C12P13/00 , C12P7/40 , C07C255/11 , C07C255/14 , C07C233/16 , C07C69/675
CPC分类号： C12P13/00 , C07C255/11 , C07C255/14 , C12P7/40 , C12P7/42 , C12P13/02 , C12P41/004 , C12P41/005
摘要： The present invention provides enzymatic processes for preparing optically active compounds of Formula (I) wherein X, E and * have the meanings defined in the specification. The invention also provides chiral intermediates useful for preparing compound of Formula (I) and enzymatic processes for preparing such chiral intermediates.
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