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公开(公告)号：EP1922307A2
公开(公告)日：2008-05-21
申请号：EP06836069.2
申请日：2006-05-17
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
IPC分类号： C07D213/84 , C07D213/63 , A61K31/44
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1922307B1
公开(公告)日：2011-12-28
申请号：EP06836069.2
申请日：2006-05-17
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
IPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/85 , A61K31/501 , A61P35/00
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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3.发明公开SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS 有权替米沙米汀 - [1,5-A] -PYRIMIDINVERBINDUNGEN ALS TRK-KINASEHEMMER
公开(公告)号：EP2451812A1
公开(公告)日：2012-05-16
申请号：EP10732606.8
申请日：2010-07-09
发明人： ALLEN, Shelley , ANDREWS, Steven S. , CONDROSKI, Kevin Ronald , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , SEO, Jeongbeob
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
摘要： Compounds of Formula II, III and IV, wherein R 3 , R 4 , Y and n are defined in the claims.
摘要翻译： 及其盐，其中R1，R2，R3，R4，X，Y和n具有本说明书中给出的含义，是Trk激酶的抑制剂，可用于治疗可用Trk激酶抑制剂如 疼痛，癌症，炎症，神经变性疾病和某些传染病。
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公开(公告)号：EP1682138A2
公开(公告)日：2006-07-26
申请号：EP04811727.9
申请日：2004-11-18
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim
IPC分类号： A61K31/44 , A61K31/50 , A61K31/415 , A61K31/501 , A61K31/655 , C07D231/02 , C07D237/02 , C07D401/00 , C07D413/00 , C07D417/00
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP3205654B1
公开(公告)日：2019-01-02
申请号：EP17163978.4
申请日：2011-05-13
发明人： ANDREWS, Steven Wade , CONDROSKI, Kevin Ronald , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob , YANG, Hong-Woon , ZHAO, Qian
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D498/22 , C07D487/22 , C07D471/22
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6.发明公开PYRROLIDINYL UREA, PYRROLIDINYL THIOUREA AND PYRROLIDINYL GUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 有权作为TRKA激酶抑制剂的吡咯烷基脲，吡咯烷基硫代脲和吡咯烷基胍的化合物
公开(公告)号：EP2712358A2
公开(公告)日：2014-04-02
申请号：EP12743553.5
申请日：2012-05-09
发明人： ALLEN, Shelley , ANDREWS, Steven, W. , BLAKE, James, F. , CONDROSKI, Kevin, R. , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439
CPC分类号： C07D403/12 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , Y02A50/414
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y—B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
摘要翻译： 式I化合物或其立体异构体，互变异构体或药学上可接受的盐或溶剂合物或前药：其中R 1，R 2，R a，R b，R c，R d，X，Y，B和环C为 如本文所定义，并且其中YB部分和NH-C（= X）-NH部分处于反式构型，是TrkA激酶的抑制剂并且可用于治疗可用TrkA激酶抑制剂治疗的疾病， 如疼痛，癌症，炎症，神经退行性疾病和某些传染病。
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公开(公告)号：EP3299372B1
公开(公告)日：2020-01-08
申请号：EP17199899.0
申请日：2010-07-09
发明人： ALLEN, Shelley , ANDREWS, Stephen, S. , CONDROSKI, Kevin Ronald , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , SEO, Jeongbeob
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D498/22 , C07D471/22 , C07D453/02 , A61K31/5377
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8.发明授权
公开(公告)号：EP2571883B1
公开(公告)日：2015-01-07
申请号：EP11728970.2
申请日：2011-05-13
发明人： ANDREWS, Steven, Wade , CONDROSKI, Kevin, Ronald , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle, R. , SEO, Jeongbeob , YANG, Hong-Woon , ZHAO, Qian
IPC分类号： C07D471/22 , C07D498/22 , C07D487/04 , C07D519/00
CPC分类号： C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
摘要： Compounds of Formula I : and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R 2 , R 2a , R 3 , R 3a , and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
摘要翻译： 式I化合物及其药学上可接受的盐，其中环A，环B，W，m，D，R 2，R 2a，R 3，R 3a和Z如本文所定义，是Trk激酶的抑制剂， 可用于治疗疼痛，癌症，炎症，神经变性疾病和某些传染病。
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公开(公告)号：EP2571883A1
公开(公告)日：2013-03-27
申请号：EP11728970.2
申请日：2011-05-13
发明人： ANDREWS, Steven, Wade , CONDROSKI, Kevin, Ronald , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle, R. , SEO, Jeongbeob , YANG, Hong-Woon , ZHAO, Qian
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00
CPC分类号： C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
摘要： Compounds of Formula I : and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R 2 , R 2a , R 3 , R 3a , and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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公开(公告)号：EP2265610B1
公开(公告)日：2012-12-12
申请号：EP09718306.5
申请日：2009-02-27
发明人： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , DE MEESE, Jason , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , LUNGHOFER, Paul , MORENO, David , NEWHOUSE, Brad , REN, Li , SEO, Jeongbeob , TIAN, Hongqi , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
IPC分类号： C07D471/04 , C07C311/08 , A61K31/437 , A61P13/12 , A61P35/00
CPC分类号： C07D471/04 , C07C311/08
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