利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.017 秒)

    PROCESS FOR PRODUCING SPHERICAL ELEMENTARY GRANULE CONTAINING READILY WATER-SOLUBLE DRUG
    1.
    发明公开
    PROCESS FOR PRODUCING SPHERICAL ELEMENTARY GRANULE CONTAINING READILY WATER-SOLUBLE DRUG 有权
    用于生产球形素颗粒，具有光水溶性药物

    公开(公告)号：EP2042162A1

    公开(公告)日：2009-04-01

    申请号：EP07790954.7

    申请日：2007-07-18

    申请人： Asahi Kasei Chemicals Corporation

    发明人： YAGINUMA, Yoshihito ,  MATSUMOTO, Rika

    IPC分类号： A61K9/16 ,  A61K47/10 ,  A61K47/26 ,  A61K47/38

    CPC分类号： A61K9/1676 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1694 ,  A61K31/192 ,  A61K31/4402

    摘要： Provided is a process for producing spherical base granules comprising a easily water-soluble drug and suited for film coating by spraying a layering liquid over pharmaceutically inert spherical core particles, thereby coating the particles with a layer comprising the easily water-soluble drug, wherein (1) the spherical core particles have a microcrystalline cellulose content of 30 mass% or greater and a water absorbing capacity of 0.5 cm 3 /g or greater; and (2) the layering liquid is an aqueous solution comprising at least the easily water-soluble drug and a low water-soluble saccharide.

    摘要翻译： 提供了一种用于制造球状素颗粒通过喷雾成层液在药学惰性的球状核粒子，由此涂覆有一层所述颗粒包含所述水易溶性药物，worin包括用于薄膜涂层的水易溶性药物和适合的处理（ 1）球状核粒子的30质量％以上的结晶纤维素和0.5厘米3 /克或更高的吸水能力; 和（2）所述成层液是wässrige溶液轻松，其包含至少水溶性药物和低水溶性糖类。

    PROCESS FOR PRODUCTION OF TABLETS CONTAINING BOTH CRYSTALLINE CELLULOSE AND GRANULES
    5.
    发明公开
    PROCESS FOR PRODUCTION OF TABLETS CONTAINING BOTH CRYSTALLINE CELLULOSE AND GRANULES 审中-公开
    用于生产片剂结晶纤维素和颗粒

    公开(公告)号：EP2184056A1

    公开(公告)日：2010-05-12

    申请号：EP08828249.6

    申请日：2008-08-26

    申请人： Asahi Kasei Chemicals Corporation

    发明人： YAGINUMA, Yoshihito ,  YOSHIDA, Naoya

    IPC分类号： A61K9/20 ,  A61K9/50 ,  A61K47/36 ,  A61K47/38 ,  C08B1/00

    CPC分类号： A61K9/2081 ,  A61K9/5078 ,  C08B1/00 ,  C08L1/02

    摘要： A process for producing a granule-containing tablet comprising mixing more than 25 mass% to 89 mass% or less of crystalline cellulose exhibiting a tensile displacement at break of 25 to 80 µm and a relative fluidity index of 2.15 to 2.80 at a maximum compaction stress of 15 kPa, 10 to 70 mass% of spherical granules, and 20 mass% or less of a disintegrant, and then compressing the obtained mixture.

    摘要翻译： 一种用于生产含有颗粒的片剂，其包括按质量计89％（质量）以下的结晶纤维素参展在25至80微米的拉伸断裂位移和在最大压实应力的2.15的相对流动性指数〜2.80的混合25％以上的处理 15千帕，10至球形颗粒的70质量％，和（质量）以下的崩解剂，然后压缩所获得的混合物的20％。

    CONTROLLED RELEASE SOLID PREPARATION
    6.
    发明公开
    CONTROLLED RELEASE SOLID PREPARATION 有权
    FESTE ZUBEREITUNG MIT KONTROLLERERTER FREISETZUNG

    公开(公告)号：EP1946780A1

    公开(公告)日：2008-07-23

    申请号：EP06823309.7

    申请日：2006-11-10

    申请人： Asahi Kasei Chemicals Corporation

    发明人： ENDO, Masaaki ,  OBAE, Kazuhiro ,  IBUKI, Ichirou ,  YAGINUMA, Yoshihito

    IPC分类号： A61K47/36 ,  A61K9/20 ,  A61K9/24 ,  A61K9/36 ,  A61K47/04 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

    CPC分类号： A61K9/2086 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/209

    摘要： Disclosed is a solid preparation which comprises at least one active ingredient and at least one dissolution-controlling base substance and can be formed by compression molding, wherein the dissolution-controlling base substance contains 5.0 to 99.9% by weight (inclusive) of a modified starch having a moisture retaining capacity of 400% or more and a gel indentation load of 200 g or more, containing a water-soluble ingredient in an amount of 40 to 95% by weight, having particles passing through a 75 µm-mesh sieve in the proportion of 90% by weight or more and particles passing through a 32 µm-mesh sieve in the proportion of 20% by weight or more, and having an average particle diameter of not smaller than 20 µm and smaller than 50 µm.

    摘要翻译： 公开了一种固体制剂，其包含至少一种活性成分和至少一种溶解控制碱性物质，并且可以通过压缩成型形成，其中所述溶解控制基质含有5.0-99.9重量％（包括）改性淀粉 具有400％以上的保湿能力和200g以上的凝胶压痕负荷，其含有40〜95重量％的水溶性成分，其中通过75μm筛网的颗粒在 比例为90重量％以上，颗粒以20重量％以上的比例通过32μm筛网，平均粒径不小于20μm且小于50μm。