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1.发明授权GELLAN GUM SPONGY-LIKE HYDROGEL, ITS PREPARATION AND BIOMEDICAL APPLICATIONS THEREOF 有权GELLAN GUM海绵状水凝胶及其制备和生物应用
公开(公告)号：EP2983727B1
公开(公告)日：2017-08-23
申请号：EP14726766.0
申请日：2014-04-09
发明人： PEREIRA DA SILVA, Lucília , TEIXEIRA CERQUEIRA, Mariana , ROMERO AMANDI DE SOUSA, Rui Pedro , PINTO MARQUES, Alexandra Margarida , CORRELO DA SILVA, Vítor Manuel , GONÇALVES DOS REIS, Rui Luís
CPC分类号： A61L27/20 , A61L27/12 , A61L27/26 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/414 , A61L2300/428 , A61L2400/18 , A61L2430/02 , C08J3/075 , C08J3/12 , C08J2305/00 , C08J2305/08 , C08K3/32 , C08K7/14 , C08L5/08 , C08L5/00
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2.发明公开GELLAN GUM SPONGY-LIKE HYDROGEL, ITS PREPARATION AND BIOMEDICAL APPLICATIONS THEREOF 有权舒马赫GELLANGUMMI HYDROGEL，DESSEN HERSTELLUNG UND BIOMEDIZINISCHE ANWENDUNGEN DAVON
公开(公告)号：EP2983727A1
公开(公告)日：2016-02-17
申请号：EP14726766.0
申请日：2014-04-09
发明人： PEREIRA DA SILVA, Lucília , TEIXEIRA CERQUEIRA, Mariana , ROMERO AMANDI DE SOUSA, Rui Pedro , PINTO MARQUES, Alexandra Margarida , CORRELO DA SILVA, Vítor Manuel , GONÇALVES DOS REIS, Rui Luís
CPC分类号： A61L27/20 , A61L27/12 , A61L27/26 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/414 , A61L2300/428 , A61L2400/18 , A61L2430/02 , C08J3/075 , C08J3/12 , C08J2305/00 , C08J2305/08 , C08K3/32 , C08K7/14 , C08L5/08 , C08L5/00
摘要： The present application discloses cell-adhesive gellan gum spongy-like hydrogels that are able to entrap/encapsulate adherent cells, which spread within the material, maintaining their phenotype and remaining viable and proliferative. The methodology used to obtain these materials involves hydrogel preparation, freezing, freeze-drying and re-hydration with a saline solution with cells and with/without bioactive molecules. No pre and/or post functionalization of the spongy-like hydrogels with cell adhesive features, as used for other hydrogels, is used. The cell adhesive character of these materials, not observed in hydrogels, is in part explained by their physical properties, between sponges and hydrogels, dissimilar from the precursor hydrogels. The physical properties that are mainly different are the morphology, microstructure, water content, and mechanical performance. Gellan gum spongy-like hydrogels physical properties and biological performance can be tuned by manipulating the parameters involved in spongy-like hydrogel formation. Bioactive molecules can also be entrapped with or without cells to modify the biological performance of the spongy-like hydrogels. These materials can be applied in the context of bioengineering, tissue engineering, regenerative medicine and biomedical applications.
摘要翻译： 本申请公开了能够捕获/包封在材料内扩散的粘附细胞的细胞粘附性吉兰糖海绵状水凝胶，保持其表型并保持活力和增殖。 用于获得这些材料的方法包括水凝胶制备，冷冻，冷冻干燥和用含有细胞和/或不含生物活性分子的盐溶液再水合。 不使用与其它水凝胶一起使用的具有细胞粘合特征的海绵状水凝胶的预和/或后功能化。 这些材料的细胞粘附特性，在水凝胶中未观察到，部分是由它们的物理性质，海绵和水凝胶之间，与前体水凝胶不相似的部分。 主要不同的物理性质是形态，微结构，含水量和机械性能。 可以通过操纵海绵状水凝胶形成中涉及的参数来调节结冷胶海绵样水凝胶的物理性质和生物学性能。 生物活性分子也可以与或不与细胞一起被捕获以改变海绵状水凝胶的生物学性能。 这些材料可以应用于生物工程，组织工程，再生医学和生物医学应用。
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