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公开(公告)号：EP2707362A1
公开(公告)日：2014-03-19
申请号：EP12722808.8
申请日：2012-05-11
申请人： AstraZeneca AB
发明人： BARNWELL, Neil , CORNWALL, Philip , GILL, Duncan, Michael , HOWELL, Gareth, P. , MEADOWS, Rebecca, Elizabeth , MERIFIELD, Eric , MITCHELL, Christopher, William , MURUGAN, Andiappan , O'KEEFE, Philip , PATEL, Zakariya, Mohamed , ROSE, James, Barry , SINGLETON, John , WITHNALL, Jane
IPC分类号： C07D277/68 , C07D498/10 , C07C309/08
CPC分类号： C07D498/10 , C07C55/07 , C07C309/08 , C07C309/24 , C07D277/68
摘要： Processes for the preparation of the compound of formula (II) and intermediate compounds for use in the processes.
摘要翻译： 制备式（II）化合物和用于该方法的中间体化合物的方法。
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2.发明公开A NEW CRYSTALLINE FORM G OF (5S)-5-[4-(5-CHLORO-PYRIDIN-2-YLOXY)-PIPERIDINE-1-SULFONYL-METHYL]-5-METHYL-IMIDAZOLIDINE-2,4-DIONE (I) AND INTERMEDIATES THEREOF. 审中-公开（5S）的新结晶G型-5- [4-（5-氯吡啶-2-基氧基） - 哌啶-1-磺酰基甲基] -5-甲基咪唑烷-2,4-二酮（1）及其中间体的
公开(公告)号：EP2064202A2
公开(公告)日：2009-06-03
申请号：EP07716068.7
申请日：2007-03-15
申请人： AstraZeneca AB
发明人： BARNWELL, Neil , BRIGGNER, Lars-Erik , COLE, Andrea , ERIKSSON, Anders , PERKINS, Jacob , VAZ, Luis-Manuel , WELLS, Andrew
IPC分类号： C07D401/12 , A61K31/454 , A61K31/4545 , A61P11/06 , A61P11/08 , A61P29/00 , C07C323/40 , C07C323/41 , C07D233/76
CPC分类号： C07D401/14 , C07C319/20 , C07C323/60
摘要： Novel crystal modifications of (5S)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonylmethyl]-5-methyl-imidazolidine-2,4-dione are disclosed together with processes for preparing such modifications, pharmaceutical compositions comprising such a modification, and the use of such a modification in therapy.
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3.发明授权3,7-DIAZABICYCLO 3.3.1| FORMULATIONS AS ANTIARHYTHMIC COMPOUNDS 有权3.7DIAZABICYCLOç3.3.1]制剂ALS抗心律失常药
公开(公告)号：EP1389213B1
公开(公告)日：2006-04-12
申请号：EP02761972.5
申请日：2002-04-12
申请人： AstraZeneca AB
发明人： BARNWELL, Neil , BJÖRE, Annika , CHEEMA, Lal , CLADINGBOEL, David , HERRING, Adam , LÖVQVIST, Karin
IPC分类号： C07D498/08 , A61K31/5386 , A61P9/06
CPC分类号： C07D498/08
摘要： There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tert-butyl 2-{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate; tert-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tert-butyl 2-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arrhythmias.
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4.发明公开3,7-DIAZABICYCLO 3.3.1] FORMULATIONS AS ANTIARHYTHMIC COMPOUNDS 有权3.7DIAZABICYCLOç3.3.1！配方ALS抗心律失常药
公开(公告)号：EP1389213A1
公开(公告)日：2004-02-18
申请号：EP02761972.5
申请日：2002-04-12
申请人： AstraZeneca AB
发明人： BARNWELL, Neil , BJÖRE, Annika , CHEEMA, Lal , CLADINGBOEL, David , HERRING, Adam , LÖVQVIST, Karin
IPC分类号： C07D498/08 , A61K31/5386 , A61P9/06
CPC分类号： C07D498/08
摘要： There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tert-butyl 2-{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate; tert-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tert-butyl 2-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arrhythmias.
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