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公开(公告)号：EP2651882B1
公开(公告)日：2018-11-14
申请号：EP11804528.5
申请日：2011-12-12
IPC分类号： C07C319/06 , C07C323/40 , C07C327/30 , C07D277/64
CPC分类号： A61K31/16 , A61K31/167 , C07C319/06 , C07C327/30 , C07C327/34 , C07C2601/14 , C07D277/64 , C07C323/40
摘要： The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is useful as a pharmaceutically active compound.
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公开(公告)号：EP1249233B9
公开(公告)日：2009-08-05
申请号：EP00976387.1
申请日：2000-11-21
申请人： SHIONOGI & CO., LTD.
发明人： KAWANISHI, Yasuyuki Shionogi & Co., Ltd. , TAKENAKA, Hideyuki Shionogi & Co., Ltd. , HANASAKI, Kohji Shionogi & Co., Ltd. , OKADA, Tetsuo Shionogi & Co., Ltd.
IPC分类号： A61K31/18 , C07C311/06 , C07C311/20 , C07C311/46 , C07C323/40 , C07D207/12 , C07D209/08 , C07D209/48 , C07D209/88 , C07D211/58 , C07D213/75 , C07D215/36 , C07D217/04 , C07D219/10 , C07D231/16 , C07D231/56 , C07D233/68 , C07D239/42 , C07D277/56 , C07D285/06 , C07D295/12 , C07D307/68 , C07D307/91 , C07D311/16 , C07D317/66 , C07D333/38 , C07D333/72 , A61P3/00
CPC分类号： C07D249/08 , A61K31/00 , A61K31/18 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/37 , A61K31/381 , A61K31/4015 , A61K31/402 , A61K31/4035 , A61K31/41 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/433 , A61K31/44 , A61K31/4409 , A61K31/4453 , A61K31/451 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K31/63 , A61K31/635 , C07C311/06 , C07C311/07 , C07C311/08 , C07C311/14 , C07C311/20 , C07C311/21 , C07C311/46 , C07C323/40 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/44 , C07C2603/18 , C07D207/09 , C07D207/12 , C07D207/16 , C07D209/08 , C07D209/48 , C07D209/88 , C07D211/58 , C07D211/62 , C07D213/75 , C07D213/82 , C07D215/36 , C07D215/38 , C07D217/04 , C07D219/10 , C07D231/12 , C07D231/16 , C07D231/56 , C07D233/56 , C07D233/68 , C07D239/42 , C07D277/56 , C07D277/70 , C07D285/06 , C07D295/135 , C07D307/68 , C07D307/91 , C07D311/16 , C07D317/66 , C07D333/38 , C07D333/72
摘要： NPYY5 receptor antagonists which contain compounds represented bygeneral formula (I), prodrugs thereof, pharmaceutically acceptable salts thereof or solvates of the same wherein R1 represents lower alkyl, cycloalkyl, etc.; R2 represents hydrogen, lower alkyl, etc.; n is 1 or 2; X represents lower alkylene, lower alkenylene, arylene, cycloalkylene, etc.; Y represents CONR?7, CSNR7, NR7CO, NR7¿CS, etc. (wherein R7 represents hydrogen or lower alkyl); and Z represents lower alkyl, an optionally substituted hydrocarbon cycle, an optionally substituted heterocycle, etc.
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3.发明公开COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION 审中-公开组合物和方法用于治疗TRP-P8相关疾病的表达
公开(公告)号：EP1663962A4
公开(公告)日：2007-08-22
申请号：EP04781589
申请日：2004-08-20
申请人： DENDREON CORP
发明人： NATARAJAN SATEESH K , MORENO OFIR , GRADDIS THOMAS J , DUNCAN DAVID , LAUS REINER , CHEN FENG
IPC分类号： A61K31/498 , A61K31/517 , A61K45/06 , A61P35/00 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07D207/06 , C07D207/09 , C07D207/32 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/20 , C07D209/48 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D251/54 , C07D263/34 , C07D263/56 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/26 , C07D307/52 , C07D317/66 , C07D333/34 , C07D401/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/68
CPC分类号： C07C233/60 , A61K31/498 , A61K31/517 , A61K45/06 , C07C233/58 , C07C243/36 , C07C243/38 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/06 , C07D207/09 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/20 , C07D209/48 , C07D211/06 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D223/04 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D241/54 , C07D251/54 , C07D263/34 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D311/16 , C07D317/66 , C07D333/34 , C07D401/04 , C07D403/14 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/5011 , G01N33/6872 , G01N2500/10 , A61K2300/00
摘要： Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Tip-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
摘要翻译： 本发明提供小分子Trp-p8调节剂，包括TRP-P8激动剂和Trp-p8的拮抗剂，和组合物包含小分子Trp-p8的激动剂，以及用于鉴定和表征新型小分子Trp-p8调节剂和方法的方法 降低活力和/或抑制TRP-P8的生长表达细胞，用于激活方法的Trp-p8的介导的阳离子内流，用于刺激细胞凋亡和/或坏死，以及相关的方法，用于治疗疾病，包括癌症的方法：如肺，乳腺 ，结肠癌和/或前列腺癌以及其他疾病，良性前列腺增生：如，没与TRP-P8表达相关。
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公开(公告)号：EP1249233A4
公开(公告)日：2005-04-13
申请号：EP00976387
申请日：2000-11-21
申请人： SHIONOGI & CO
IPC分类号： A61K20060101 , A61K31/00 , A61K31/18 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/37 , A61K31/381 , A61K31/4015 , A61K31/402 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/433 , A61K31/44 , A61K31/4409 , A61K31/4453 , A61K31/451 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/535 , A61K31/5375 , A61K31/63 , A61K31/635 , A61P20060101 , A61P3/04 , A61P43/00 , C07C20060101 , C07C311/06 , C07C311/07 , C07C311/08 , C07C311/14 , C07C311/20 , C07C311/21 , C07C311/46 , C07C323/40 , C07D20060101 , C07D207/09 , C07D207/12 , C07D207/16 , C07D209/08 , C07D209/48 , C07D209/88 , C07D211/08 , C07D211/58 , C07D211/62 , C07D213/75 , C07D213/82 , C07D215/36 , C07D215/38 , C07D217/04 , C07D219/10 , C07D231/12 , C07D231/16 , C07D231/56 , C07D233/68 , C07D239/42 , C07D241/02 , C07D261/08 , C07D265/30 , C07D277/46 , C07D277/56 , C07D277/70 , C07D285/06 , C07D295/135 , C07D307/02 , C07D307/68 , C07D307/91 , C07D311/16 , C07D317/66 , C07D333/38 , C07D333/72 , C07D521/00 , A61P3/00 , C07D295/12
CPC分类号： C07D249/08 , A61K31/00 , A61K31/18 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/37 , A61K31/381 , A61K31/4015 , A61K31/402 , A61K31/4035 , A61K31/41 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/433 , A61K31/44 , A61K31/4409 , A61K31/4453 , A61K31/451 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K31/63 , A61K31/635 , C07C311/06 , C07C311/07 , C07C311/08 , C07C311/14 , C07C311/20 , C07C311/21 , C07C311/46 , C07C323/40 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/44 , C07C2603/18 , C07D207/09 , C07D207/12 , C07D207/16 , C07D209/08 , C07D209/48 , C07D209/88 , C07D211/58 , C07D211/62 , C07D213/75 , C07D213/82 , C07D215/36 , C07D215/38 , C07D217/04 , C07D219/10 , C07D231/12 , C07D231/16 , C07D231/56 , C07D233/56 , C07D233/68 , C07D239/42 , C07D277/56 , C07D277/70 , C07D285/06 , C07D295/135 , C07D307/68 , C07D307/91 , C07D311/16 , C07D317/66 , C07D333/38 , C07D333/72
摘要： NPYY5 receptor antagonists which contain compounds represented bygeneral formula (I), prodrugs thereof, pharmaceutically acceptable salts thereof or solvates of the same wherein R1 represents lower alkyl, cycloalkyl, etc.; R2 represents hydrogen, lower alkyl, etc.; n is 1 or 2; X represents lower alkylene, lower alkenylene, arylene, cycloalkylene, etc.; Y represents CONR?7, CSNR7, NR7CO, NR7¿CS, etc. (wherein R7 represents hydrogen or lower alkyl); and Z represents lower alkyl, an optionally substituted hydrocarbon cycle, an optionally substituted heterocycle, etc.
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5.发明公开
公开(公告)号：EP1472214A2
公开(公告)日：2004-11-03
申请号：EP03737732.2
申请日：2003-02-10
IPC分类号： C07C237/10 , C07C323/29 , C07C323/40 , C07C323/41 , C07C323/42 , C07C323/44 , C07C323/49 , C07C323/52 , C07C323/60 , C07C335/18 , C07D207/32 , C07D213/38 , C07D213/70 , C07D213/73 , C07D213/81
CPC分类号： C07D207/335 , C07C45/46 , C07C45/673 , C07C205/56 , C07C211/29 , C07C229/34 , C07C233/11 , C07C237/10 , C07C237/14 , C07C317/44 , C07C323/29 , C07C323/40 , C07C323/41 , C07C323/42 , C07C323/44 , C07C323/49 , C07C323/52 , C07C323/60 , C07C335/18 , C07C2601/02 , C07C2601/14 , C07D211/24 , C07D211/96 , C07D213/38 , C07D213/70 , C07D213/73 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/20 , C07D233/64 , C07D271/06 , C07D277/28 , C07D277/64 , C07D295/185 , C07D413/12 , C07C49/83
摘要： Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following struture (I): (I)including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W1, W2, X, R1, R2, R3, R4, m and n are defined herein.
摘要翻译： 化合物，组合物和用于改变胰岛素分泌，特别是在治疗的受试者具有，或用于具有被怀疑处于危险，糖尿病的上下文中的方法。 所述化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，worinW¯¯ 1 ，W 2 ，X，R 1 ，R 2 ，R 3 ，R 4 ，m和n中所定义。
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公开(公告)号：EP1243577A1
公开(公告)日：2002-09-25
申请号：EP00985876.2
申请日：2000-12-26
申请人： Ajinomoto Co., Inc.
发明人： TANAKA, Y. Pharmac. Res. Lab., Ajinomoto Co., Inc , YOSHIMURA, T. Pharmac.Res. Lab., Ajinomoto Co.Inc , EJIMA, Ch. Pharmac. Res. Lab., Ajinomoto Co.,Inc. , KOJIMA, M. Pharmac. Res. Lab., Ajinomoto Co., Inc , NAKANISHI, E. Pharm. Res. Lab.,Ajinomoto Co.,Inc. , IZAWA, H. Pharm. Res. Lab., Ajinomoto Co., Inc. , SATAKE, Yuko Pharm. Res. Lab.,Ajinomoto Co., Inc. , SUZUKI, N. Pharm. Res. Lab., Ajinomoto Co., Inc. , SUZUKI, M. Pharm. Res. Lab., Ajinomoto Co., Inc. , MURATA, M. Pharm. Res. Lab., Ajinomoto Co., Inc.
IPC分类号： C07C233/63 , C07C243/36 , C07C281/06 , C07C255/65 , C07C311/21 , C07C311/46 , C07C323/40 , C07D285/06 , C07D239/38 , A61K31/198 , A61K31/433 , A61K31/505
CPC分类号： C07D295/185 , C07C233/63 , C07C243/36 , C07C311/21 , C07C311/46 , C07C323/40 , C07C2601/14 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/46 , C07D211/58 , C07D211/62 , C07D217/06 , C07D233/52 , C07D239/38 , C07D285/06 , C07D295/32
摘要： Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to α 4 β 7 integrin and a selectivity toward α 4 β 1 integrin. They are used as therapeutic agents for various diseases to which α 4 β 7 integrin relates.
摘要翻译： 下式的苯丙氨酸衍生物及其类似物对α4β7整联蛋白具有拮抗作用和对α4β1整联蛋白的选择性。 它们被用作α4β7整联蛋白涉及的各种疾病的治疗剂。
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公开(公告)号：EP0888389A4
公开(公告)日：2001-03-14
申请号：EP97920012
申请日：1997-03-20
申请人： SURMODICS INC
发明人： SWANSON MELVIN J , AMOS RICHARD A , SWAN DALE G , OPPERMAN GARY W
IPC分类号： C07C323/12 , C07C323/22 , C07C323/40 , C07C323/41 , C07C323/42 , C07C323/52 , C08F2/38 , C08F2/48 , C08F2/50 , C08F4/00 , C08F20/00 , C08J7/04 , G03F7/028 , C08J3/28
CPC分类号： C08J7/047 , C07C323/12 , C07C323/22 , C07C323/41 , C07C323/42 , C08F2/38 , C08J2323/12 , C08J2433/00 , C08J2439/00 , C08J2485/00 , Y10S522/904 , Y10S522/905
摘要： A photoactivatable reagent useful as a chain transfer reagent for providing a semitelechelic polymer having one or more terminal photoactivatable groups. The reagent provides one or more photoactivatable groups and one or more sulfhydryl (or other chain transfer) groups, the photoactivatable and chain transfer groups optionally being joined together by a spacer group. The reagent can be used to prepare a polymer by serving to initiate the polymerization of ethylenically unsaturated monomers. The reagent itself becomes an integral part of the resultant polymer, thereby providing the polymer with a terminal photoactivatable nature. The method provides a number of benefits, including the ability to provide homogeneous photoactivatable polymer compositions, e.g., in terms of the uniform location of the photogroup(s) on the terminal portion of each polymer molecule and the ability to build a desired nonpolar quality, and in turn improved surfactancy, into otherwise polar polymers.
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8.发明授权1-(2-ETHYL-BUTYL)-CYCLOHEXANECARBOXYLIC ACID ESTER AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY ACTIVE AMIDES 有权1-（2-乙基 - 丁基）-CYCLOHEXANCARBONSÄUREESTERALS ZWISCHENPRODUKTFÜRDIE HERSTELLUNG VON PHARMAZEUTISCH AKTIVEN AMIDEN
公开(公告)号：EP2297081B1
公开(公告)日：2017-03-08
申请号：EP09765761.3
申请日：2009-06-08
发明人： LOHRI, Bruno
IPC分类号： C07C51/09 , C07C51/60 , C07C61/08 , C07C67/343 , C07C69/75 , C07C319/06 , C07C319/22 , C07C323/40 , C07C327/30
CPC分类号： C07C51/60 , C07C51/09 , C07C67/343 , C07C69/75 , C07C319/06 , C07C319/22 , C07C327/30 , C07C2601/14 , C07C61/08 , C07C323/40
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9.发明公开PROCESS FOR THE PREPARATION OF AROMATIC THIOL DERIVATIVES BY HYDROGENATION OF DISULFIDES 审中-公开工艺制备芳族巯基衍生物通过二硫键的加氢
公开(公告)号：EP2651882A1
公开(公告)日：2013-10-23
申请号：EP11804528.5
申请日：2011-12-12
IPC分类号： C07C319/06 , C07C323/40 , C07C327/30 , C07D277/64
CPC分类号： A61K31/16 , A61K31/167 , C07C319/06 , C07C327/30 , C07C327/34 , C07C2601/14 , C07D277/64 , C07C323/40
摘要： The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is useful as a pharmaceutically active compound.
摘要翻译： 本发明涉及一种用于S-的制备[2- [1-（2-乙基丁基）环己基羰基]苯基] -2-甲硫基丙所有这些是作为药物活性化合物是有用的。
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10.发明授权PROCESS FOR PREPARING 1-(2-ETHYL-BUTYL)-CYCLOHEXANECARBOXYLIC ACID 有权VERFAHREN ZUR HERSTELLUNG VON 1 - （ - 2-ETHYLBUTYL）-CYCLOHEXANCARBONSÄURE
公开(公告)号：EP2094636B1
公开(公告)日：2012-10-24
申请号：EP07848018.3
申请日：2007-12-10
发明人： HOFFMANN, Ursula , LOHRI, Bruno
IPC分类号： C07C319/22 , C07C323/40 , C07C51/48 , C07C51/353 , C07C61/08 , C07C319/06 , C07C319/20 , C07C327/30 , C07C321/24 , C07C321/28 , C07C51/60
CPC分类号： C07C323/40 , C07C51/353 , C07C51/48 , C07C319/06 , C07C319/22 , C07C327/30 , C07C2601/14 , C07C61/08
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