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1.发明公开QUINICLIDINE DERIVATIVES OF (HETERO) ARYLCYCLOHEPTANECARBOXYLIC ACID AS MUSCARINIC RECEPTOR ANTAGONISTS 有权（杂芳基）芳基环庚烷羧酸作为麦考酚酸受体拮抗剂的喹吖啶衍生物
公开(公告)号：EP2094694A1
公开(公告)日：2009-09-02
申请号：EP07824574.3
申请日：2007-11-13
申请人： AstraZeneca AB
发明人： FORD, Rhonan , MATHER, Andrew , METE, Antonio
IPC分类号： C07D453/02 , A61K31/439
CPC分类号： C07D453/02
摘要： The invention provides compounds of formula (I) wherein R4 is a group of formula (II) or (IIIa) or (IIIb) and R1, R2, R3, R5, a, b and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation (I), (II), (IIIa), (IIIb).
摘要翻译： 本发明提供了其中R 4为式（II）或（IIIa）或（IIIb）的基团且R 1，R 2，R 3，R 5，a，b和X如说明书中所定义的式 它们的制备，含有它们的药物组合物，制备药物组合物的方法，它们在治疗中的用途以及在其制备（I），（II），（IIIa），（IIIb）中使用的中间体。
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公开(公告)号：EP2427445A1
公开(公告)日：2012-03-14
申请号：EP10719056.3
申请日：2010-05-05
申请人： AstraZeneca AB
发明人： FORD, Rhonan , METE, Antonio , MATHER, Andrew , MILLICHIP, Ian
IPC分类号： C07D309/14 , A61K31/351 , A61P11/00
CPC分类号： C07D309/14
摘要： The present invention provides compounds of formula (I), in which y, m, n, R
1 , R
2 and Q are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.摘要翻译： 本发明提供了式（I）化合物，其中y，m，n，R 1，R 2和Q如说明书中所定义，其制备方法，含有它们的药物组合物以及它们在治疗中的用途。
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3.发明公开PHARMACEUTICAL PRODUCT COMPRISING A MUSCARINIC RECEPTOR ANTAGONIST AND A beta2-ADRENOCEPTOR AGONIST 审中-公开药物产品包含毒蕈碱性受体拮抗剂和β2 BLOCKING激动剂
公开(公告)号：EP2315589A1
公开(公告)日：2011-05-04
申请号：EP09746868.0
申请日：2009-05-12
发明人： BULL, Richard , FORD, Rhonan , MATHER, Andrew , METE, Antonio , WILEY, Katherine
IPC分类号： A61K31/439 , A61P11/06 , A61P11/08 , A61K31/428
CPC分类号： A61K45/06 , A61K31/428 , A61K31/439 , A61K2300/00
摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist, and a second active ingredient which is a &bgr;2-adrenoceptor agonist, or use in the treatment of respiratory diseases such as chronic obstructive pulmonary disease and asthma.
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4.发明授权QUINICLIDINE DERIVATIVES OF (HETERO) ARYLCYCLOHEPTANECARBOXYLIC ACID AS MUSCARINIC RECEPTOR ANTAGONISTS 有权OF（杂）ARYLCYCLOHEPTANCARBONSÄURENCHINICLIDINDERIVATE作为反对者AM毒蕈碱
公开(公告)号：EP2094694B1
公开(公告)日：2011-01-26
申请号：EP07824574.3
申请日：2007-11-13
申请人： AstraZeneca AB
发明人： FORD, Rhonan , MATHER, Andrew , METE, Antonio
IPC分类号： C07D453/02 , A61K31/439
CPC分类号： C07D453/02
摘要： The invention provides compounds of formula (I) wherein R4 is a group of formula (II) or (IIIa) or (IIIb) and R1, R2, R3, R5, a, b and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation (I), (II), (IIIa), (IIIb).
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