公开(公告)号：EP3292105B1

公开(公告)日：2019-10-02

申请号：EP16720116.9

申请日：2016-05-03

申请人： AstraZeneca AB

发明人： BRODDEFALK, Johan, Olof ,  EMTENÄS, Hans, Fredrik ,  GRANBERG, Kenneth, Lars ,  LEMURELL, Malin, Anita ,  PETTERSEN, Daniel, Tor ,  PLOWRIGHT, Alleyn, Thomas ,  ULANDER, Lars, Johan, Andreas

IPC分类号： C07D231/40 ,  C07D231/44 ,  C07D231/50 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04 ,  A61K31/4155 ,  A61P9/00

公开(公告)号：EP2190840A2

公开(公告)日：2010-06-02

申请号：EP08788687.5

申请日：2008-08-15

申请人： AstraZeneca AB

发明人： BIRCH, Alan, Martin ,  BUTLIN, Roger, John ,  GILL, Adrian, Liam ,  GROOMBRIDGE, Samuel, David ,  PLOWRIGHT, Alleyn, Thomas ,  WARING, Michael, James

IPC分类号： C07D413/12 ,  A61K31/4245 ,  A61P3/00

CPC分类号： C07D413/12

摘要： Compounds of formula (I), or pharmaceutically-acceptable salts and/or pro-drugs thereof, which inhibit acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein n is 0 to 3; p is 0 or 1; q is 0 to 2; R1and R2are, for example, independently fluoro, chloro, bromo, cyano or (1-4C)alkyl; X is -O-, -S- or -NRa- wherein Ra is hydrogen or (1-4C)alkyl; RA1 and RA2 are, for example, independently hydrogen or (1-4C)alkyl; Ring A is a di-linked ring or ring system chosen from (4-6C)cycloalkane, (7- 10C)bicycloalkane and (8-12C)tricycloalkane each optionally substituted, for example, by one substituent selected from (1-4C)alkyl, (1-4C)alkoxy and (1-4C)alkoxy(1-4C)alkyl; or Ring A is phenylene optionally substituted, for example, by up to four substituents selected from fluoro, chloro, bromo, cyano, (1-4C)alkyl, (1-4C)alkoxy and (1- 4C)alkoxy(1-4C)alkyl; togetherwith processes for their preparation, pharmaceutical compositions containing them and their use as medicaments.

公开(公告)号：EP3670499A1

公开(公告)日：2020-06-24

申请号：EP19199606.5

申请日：2016-05-03

申请人： Astrazeneca AB

发明人： BRODDEFALK, Johan Olof ,  EMTENÄS, Hans Fredrik ,  GRANBERG, Kenneth, Lars ,  LEMURELL, Malin, Anita ,  PETTERSEN, Daniel, Tor ,  PLOWRIGHT, Alleyn, Thomas ,  ULANDER, Lars Johan, Andreas

IPC分类号： C07D231/40 ,  C07D231/44 ,  C07D231/50 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04 ,  A61K31/4155 ,  A61P9/00

摘要： The present application relates to novel compounds of formula (I)

to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

公开(公告)号：EP3292105A1

公开(公告)日：2018-03-14

申请号：EP16720116.9

申请日：2016-05-03

申请人： AstraZeneca AB

发明人： BRODDEFALK, Johan, Olof ,  EMTENÄS, Hans, Fredrik ,  GRANBERG, Kenneth, Lars ,  LEMURELL, Malin, Anita ,  PETTERSEN, Daniel, Tor ,  PLOWRIGHT, Alleyn, Thomas ,  ULANDER, Lars, Johan, Andreas

IPC分类号： C07D231/40 ,  C07D231/44 ,  C07D231/50 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04 ,  A61K31/4155 ,  A61P9/00

CPC分类号： C07D487/04 ,  C07D231/40 ,  C07D231/44 ,  C07D231/50 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04

摘要： to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.