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公开(公告)号：EP2094670A1
公开(公告)日：2009-09-02
申请号：EP07824500.8
申请日：2007-11-08
申请人： AstraZeneca AB
发明人： GREWAL, Gurmit , HENNESSY, Edward , KAMHI, Victor , LI, Danyang , LYNE, Paul , OZA, Vibha , SAEH, Jamal Carlos , SU, Qibin , YANG, Bin
IPC分类号： C07D235/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D487/04 , C07D491/056
CPC分类号： C07D235/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D487/04 , C07D491/056
摘要： The invention relates to chemical compounds of formula (I), (Ia) and (Ib) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man.
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公开(公告)号：EP2601186A2
公开(公告)日：2013-06-12
申请号：EP11746007.1
申请日：2011-08-02
申请人： AstraZeneca AB
发明人： AQUILA, Brian , KAMHI, Victor , PENG, Bo , PONTZ, Timothy , SAEH, Jamal Carlos , THAKUR, Kumar , YANG, Bin
IPC分类号： C07D401/14 , C07F9/6568 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07F9/65685
摘要： The present invention relates to compounds of Formula (I) and/or Formula (Ia): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit ALK kinase activity, and thus may be used for the treatment of cancer.
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公开(公告)号：EP2601177B1
公开(公告)日：2017-10-18
申请号：EP11746295.2
申请日：2011-08-05
申请人： AstraZeneca AB
发明人： DIEBOLD, Robert Bruce , GERO, Thomas , GROVER, Paul , HUANG, Shan , IOANNIDIS, Stephanos , OGOE, Claude Afona , SAEH, Jamal Carlos , VARNES, Jeffrey Gilbert
IPC分类号： C07D211/22 , A61K31/445 , A61P35/00 , A61P35/02
CPC分类号： C07F9/65583 , A61K31/451 , A61K31/496 , A61K31/5377 , A61K31/675 , C07D211/22 , C07D211/34 , C07D413/12 , C07F9/58 , C07F9/59 , C07F9/650952
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公开(公告)号：EP2601177A1
公开(公告)日：2013-06-12
申请号：EP11746295.2
申请日：2011-08-05
申请人： AstraZeneca AB
发明人： DIEBOLD, Robert Bruce , GERO, Thomas , GROVER, Paul , HUANG, Shan , IOANNIDIS, Stephanos , OGOE, Claude Afona , SAEH, Jamal Carlos , VARNES, Jeffrey Gilbert
IPC分类号： C07D211/22 , A61K31/445 , A61P35/00 , A61P35/02
CPC分类号： C07F9/65583 , A61K31/451 , A61K31/496 , A61K31/5377 , A61K31/675 , C07D211/22 , C07D211/34 , C07D413/12 , C07F9/58 , C07F9/59 , C07F9/650952
摘要： The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-X
L activities and may be used for the treatment of cancer.摘要翻译： 本发明涉及式（I）化合物及其盐，药物组合物，使用方法及其制备方法。 这些化合物抑制Bcl-2和/或Bcl-XL活性，并可用于治疗癌症。
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5.发明公开
公开(公告)号：EP2440549A1
公开(公告)日：2012-04-18
申请号：EP10725266.0
申请日：2010-06-10
申请人： AstraZeneca AB
发明人： AQUILA, Brian , HENNESSY, Edward , HIRD, Alexander , OZA, Vibha , SAEH, Jamal Carlos , SHA, Li
IPC分类号： C07D403/12 , A61K31/4025 , A61P35/00
CPC分类号： C07D403/12
摘要： Provided herein are 2,3-dihydro-1H-indene compounds, methods for making the compounds, pharmaceutical compositions containing the compounds. The described compounds inhibit IAP proteins and can be used to treat various cancers.
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