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1.发明公开
公开(公告)号：EP2440549A1
公开(公告)日：2012-04-18
申请号：EP10725266.0
申请日：2010-06-10
申请人： AstraZeneca AB
发明人： AQUILA, Brian , HENNESSY, Edward , HIRD, Alexander , OZA, Vibha , SAEH, Jamal Carlos , SHA, Li
IPC分类号： C07D403/12 , A61K31/4025 , A61P35/00
CPC分类号： C07D403/12
摘要： Provided herein are 2,3-dihydro-1H-indene compounds, methods for making the compounds, pharmaceutical compositions containing the compounds. The described compounds inhibit IAP proteins and can be used to treat various cancers.
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公开(公告)号：EP2188255A1
公开(公告)日：2010-05-26
申请号：EP08788726.1
申请日：2008-08-29
申请人： AstraZeneca AB
发明人： DAKIN, Leslie , FAUBER, Benjamin , HIRD, Alexander , JANETKA, James , RUSSELL, Daniel, John , SU, Qibin , YANG, Bin , ZHENG, XiaoLan
IPC分类号： C07D213/30 , C07D213/40 , C07D213/73 , C07D233/61 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D473/00 , C07D513/04 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/4427 , A61P35/00
CPC分类号： C07D401/12 , C07D213/30 , C07D213/40 , C07D213/73 , C07D233/61 , C07D413/12 , C07D417/12 , C07D417/14 , C07D473/00 , C07D513/04
摘要： The present disclosure relates to heterocyclic amide compounds, which are useful for inhibiting the Hedgehog pathway, and their use in treating a disease or medical condition mediated alone or in part by Hedgehog pathway inhibition. Also disclosed are methods for manufacture of these compounds, pharmaceutical compositions including these compounds, and use of these compounds in the manufacture of medicaments for treating such diseases and medical conditions in a subject. Formula (IA) with the provisio that either R2or R3 is (Z).
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公开(公告)号：EP3445767B1
公开(公告)日：2020-02-19
申请号：EP17720720.6
申请日：2017-04-21
申请人： Astrazeneca AB
发明人： HIRD, Alexander , BELMONTE, Matthew, Alan , YANG, Wenzhan , SECRIST, John, Paul , ROBBINS, Daniel, William , KAZMIRSKI, Steven, Lee , WU, Dedong , PENG, Bo , JOHANNES, Jeffrey , LAMB, Michelle, Laurae , YE, Qing , ZHENG, Xiaolan
IPC分类号： C07D515/22 , A61K31/395 , A61P35/00
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公开(公告)号：EP3601230A1
公开(公告)日：2020-02-05
申请号：EP18714249.2
申请日：2018-03-29
申请人： Astrazeneca AB
发明人： STEWART, Craig , HARDY, Simon , STARK, Andrew , HIRD, Alexander , YE, Qing , ZHENG, Xiaolan , FERRAR, Cati , KOEK, Jan , HAZRA, Debasis
IPC分类号： C07D231/12 , C07D403/04 , C07C245/06
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公开(公告)号：EP3313838B1
公开(公告)日：2019-04-03
申请号：EP16733459.8
申请日：2016-06-27
申请人： Astrazeneca AB
发明人： PIKE, Kurt, Gordon , BARLAAM, Bernard, Christophe , HAWKINS, Janet , DE SAVI, Christopher , VASBINDER, Melissa, Marie , HIRD, Alexander , LAMB, Michelle
IPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP3313838A1
公开(公告)日：2018-05-02
申请号：EP16733459.8
申请日：2016-06-27
申请人： Astrazeneca AB
发明人： PIKE, Kurt, Gordon , BARLAAM, Bernard, Christophe , HAWKINS, Janet , DE SAVI, Christopher , VASBINDER, Melissa, Marie , HIRD, Alexander , LAMB, Michelle
IPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , A61K31/437 , A61P35/00
CPC分类号： C07D498/04 , C07B2200/13 , C07D471/04 , C07D487/04
摘要： Provided are a series of novel pyridine or pyrimidine derivatives which inhibit CDK9 and may be useful for the treatment of hyperproliferative diseases. In particular the compounds are of use in the treatment of proliferative disease such as cancer including hematological malignancies such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt's lymphoma, follicular lymphoma and solid tumors such as breast cancer, lung cancer, neuroblastoma and colon cancer.
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