公开(公告)号：EP2013186A1

公开(公告)日：2009-01-14

申请号：EP07732487.9

申请日：2007-04-20

申请人： AstraZeneca AB

发明人： GREWAL, Gurmit ,  OZA, Vibha ,  SAEH, Jamal, Carlos ,  SU, Qibin

IPC分类号： C07D233/54 ,  A61K31/41 ,  A61P35/00

CPC分类号： C07D233/64

摘要： The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

公开(公告)号：EP2013184A1

公开(公告)日：2009-01-14

申请号：EP07732469.7

申请日：2007-04-20

申请人： AstraZeneca AB

发明人： GREWAL, Gurmit ,  HENNESSY, Edward ,  KAMHI, Victor ,  LI, Danyang ,  OZA, Vibha ,  SAEH, Jamal, Carlos ,  SU, Qibin

IPC分类号： C07D231/12 ,  C07D231/20 ,  C07D231/38 ,  C07D261/08 ,  C07D261/10 ,  C07D261/12 ,  C07D275/02 ,  A61P7/02 ,  A61P9/10 ,  A61P19/02 ,  A61P31/00 ,  A61P35/00 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425

CPC分类号： C07D231/12 ,  C07D231/20 ,  C07D231/38 ,  C07D261/08 ,  C07D261/10 ,  C07D261/12 ,  C07D275/02 ,  C07D275/03

摘要： The present invention relates to compounds of formula (I) that mediate Edg, including Edg-1, 1 processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant vascularization or inflammatory component such as in tumor-related diseases. The present invention also relates to compounds that inhibit a5b1, and also that exhibit appropriate selectivity profile(s) against other integrins.

公开(公告)号：EP2440549A1

公开(公告)日：2012-04-18

申请号：EP10725266.0

申请日：2010-06-10

申请人： AstraZeneca AB

发明人： AQUILA, Brian ,  HENNESSY, Edward ,  HIRD, Alexander ,  OZA, Vibha ,  SAEH, Jamal Carlos ,  SHA, Li

IPC分类号： C07D403/12 ,  A61K31/4025 ,  A61P35/00

CPC分类号： C07D403/12

摘要： Provided herein are 2,3-dihydro-1H-indene compounds, methods for making the compounds, pharmaceutical compositions containing the compounds. The described compounds inhibit IAP proteins and can be used to treat various cancers.

公开(公告)号：EP1979332A1

公开(公告)日：2008-10-15

申请号：EP07700377.0

申请日：2007-01-15

申请人： AstraZeneca AB

发明人： COWEN, Scott ,  DEEGAN, Tracy ,  GREWAL, Gurmit ,  OZA, Vibha ,  SAEH, Jamal, Carlos ,  SU, Qibin

IPC分类号： C07D249/08 ,  C07D401/06 ,  A61K31/4196 ,  A61P35/00

CPC分类号： C07D249/08 ,  C07D401/06

摘要： The invention relates to chemical compounds of formula (I) and (II) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

摘要翻译： 本发明涉及式（I）和（II）的化学化合物或其药学上可接受的盐，其具有Edg-1拮抗活性并因此可用于其抗癌活性并因此用于治疗人体或动物体的方法。 本发明还涉及制造所述化合物的方法，含有它们的药物组合物，以及它们在制备用于在温血动物例如人中产生抗癌作用的药物中的用途。

公开(公告)号：EP2094670A1

公开(公告)日：2009-09-02

申请号：EP07824500.8

申请日：2007-11-08

申请人： AstraZeneca AB

发明人： GREWAL, Gurmit ,  HENNESSY, Edward ,  KAMHI, Victor ,  LI, Danyang ,  LYNE, Paul ,  OZA, Vibha ,  SAEH, Jamal Carlos ,  SU, Qibin ,  YANG, Bin

IPC分类号： C07D235/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D473/40 ,  C07D487/04 ,  C07D491/056

CPC分类号： C07D235/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D473/40 ,  C07D487/04 ,  C07D491/056

摘要： The invention relates to chemical compounds of formula (I), (Ia) and (Ib) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man.

公开(公告)号：EP1660474B1

公开(公告)日：2008-10-29

申请号：EP04768043.4

申请日：2004-08-12

申请人： AstraZeneca AB

发明人： ASHWELL, Susan ,  GERO, Thomas ,  IOANNIDIS, Stophanos ,  JANETKA, James ,  LYNE, Paul ,  OZA, Vibha ,  SPRINGER, Stephanie ,  SU, Mei ,  YU, Dingwei

IPC分类号： C07D333/38 ,  C07D409/12 ,  A61K31/38 ,  A61P35/00

CPC分类号： C07D333/68 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D453/02 ,  C07D453/06

摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

公开(公告)号：EP1869016A1

公开(公告)日：2007-12-26

申请号：EP06710029.7

申请日：2006-03-07

申请人： AstraZeneca AB

发明人： ANDREWS, David ,  FINLAY, Maurice Raymond ,  GREEN, Clive ,  JONES, Clifford ,  OZA, Vibha

IPC分类号： C07D401/14 ,  C07D403/14 ,  A61K31/506 ,  A61P35/02

CPC分类号： C07D403/14 ,  C07D401/14

摘要： Compounds of the formula (I): wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti cell proliferation) effect in a warm blooded animal, such as man.

公开(公告)号：EP1660474A1

公开(公告)日：2006-05-31

申请号：EP04768043.4

申请日：2004-08-12

申请人： AstraZeneca AB

发明人： ASHWELL, Susan ,  GERO, Thomas ,  IOANNIDIS, Stophanos ,  JANETKA, James ,  LYNE, Paul ,  OZA, Vibha ,  SPRINGER, Stephanie ,  SU, Mei ,  YU, Dingwei

IPC分类号： C07D333/38 ,  C07D409/12 ,  A61K31/38 ,  A61P35/00 ,  C07D333/00 ,  C07D307/00 ,  C07D241/00

CPC分类号： C07D333/68 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D453/02 ,  C07D453/06

摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cancer.