-
1.发明授权
公开(公告)号：EP1421070B1
公开(公告)日：2008-11-26
申请号：EP02760961.9
申请日：2002-08-21
申请人： AstraZeneca AB
IPC分类号： C07D265/30 , C07D211/20 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4523 , A61K31/5377 , A61P11/00 , A61P19/00 , A61P31/00 , A61P37/00
CPC分类号： C07D413/12
摘要： The invention provides compounds of formula (I), in which m, n, X, Y, R?1, R2 and R3¿ are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; and their use in therapy.
-
公开(公告)号：EP1521757B1
公开(公告)日：2008-01-30
申请号：EP03762957.3
申请日：2003-07-07
申请人： AstraZeneca AB
IPC分类号： C07D491/10 , C07D471/10 , C07D221/20 , C07D209/54 , A61K31/438 , A61K31/403 , A61K31/407 , A61P11/06
CPC分类号： C07D221/20 , C07D491/10 , Y02P20/55
摘要： The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
-
3.发明公开NOVEL TRICYCLIC SPIRODERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开新三环螺衍生物作为趋化因子受体的调节剂
公开(公告)号：EP1699791A1
公开(公告)日：2006-09-13
申请号：EP04809111.0
申请日：2004-12-20
申请人： AstraZeneca AB
IPC分类号： C07D471/10 , C07D221/20 , C07D209/54 , A61K31/438 , A61K31/403 , A61K31/407 , A61P11/06 , A61P11/08 , A61P19/02 , A61P29/00
CPC分类号： C07D491/10 , A61K31/403 , A61K31/407 , A61K31/438
摘要： The invention provides compounds of formula (I) wherein m, R1, n, R2, q, p, X, Y, R3, R4, t and, R5 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
-
4.发明授权3,4-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF ENAC MEDIATED DISEASES 有权3,4-二氨基-6-氯吡嗪-2-羧酰胺类化合物用于治疗ENAC介导的疾病
公开(公告)号：EP3119752B1
公开(公告)日：2018-05-16
申请号：EP15713339.8
申请日：2015-03-17
申请人： Astrazeneca AB
发明人： BERGLUND, Susanne, Elisabeth , CONNOLLY, Stephen , HEMMERLING, Martin , HOSSAIN, Nafizal , KRISTOFFERSSON, Anna , LUNDKVIST, Johan, Rune, Michael , NIKITIDIS, Grigorios , RIPA, Lena, Elisabeth , SHAMOVSKY, Igor
IPC分类号： C07D401/06 , C07D241/28 , A61K31/497 , A61P11/00
CPC分类号： C07D401/12 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D241/26 , C07D241/28 , C07D401/06
摘要： The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).
-
5.发明授权PIPERIDINYL-MORPHOLINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权PIPERIDINYLMORPHOLINYLDERIVATE作为趋化因子受体的调节剂
公开(公告)号：EP1421082B1
公开(公告)日：2006-01-11
申请号：EP02760960.1
申请日：2002-08-21
申请人： AstraZeneca AB
IPC分类号： C07D413/04 , C07D413/14 , A61K31/5377 , A61P11/00 , A61P19/00 , A61P31/00 , A61P37/00
CPC分类号： C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention provides compounds of general formula (I), in which m, n, Z?1, Z2, R1, R2, R3, R4 and R5¿ are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; and their use in therapy.
-
公开(公告)号：EP1521757A1
公开(公告)日：2005-04-13
申请号：EP03762957.3
申请日：2003-07-07
申请人： AstraZeneca AB
IPC分类号： C07D491/10 , C07D471/10 , C07D221/20 , C07D209/54 , A61K31/438 , A61K31/403 , A61K31/407 , A61P11/06
CPC分类号： C07D221/20 , C07D491/10 , Y02P20/55
摘要： The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
-
公开(公告)号：EP3119752A1
公开(公告)日：2017-01-25
申请号：EP15713339.8
申请日：2015-03-17
申请人： Astrazeneca AB
发明人： BERGLUND, Susanne, Elisabeth , CONNOLLY, Stephen , HEMMERLING, Martin , HOSSAIN, Nafizal , KRISTOFFERSSON, Anna , LUNDKVIST, Johan, Rune, Michael , NIKITIDIS, Grigorios , RIPA, Lena, Elisabeth , SHAMOVSKY, Igor
IPC分类号： C07D401/06 , C07D241/28 , A61K31/497 , A61P11/00
CPC分类号： C07D401/12 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D241/26 , C07D241/28 , C07D401/06
摘要： The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).
摘要翻译： 本发明提供式（I）的化合物或其药学上可接受的盐; 制备这种化合物的方法; 以及在治疗ENaC介导的疾病状态（例如哮喘，CF或COPD）中使用这种化合物。
-
8.发明公开NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA 审中-公开NEW FOR治疗哮喘和COPD的适当的1-苄基-4-哌啶
公开(公告)号：EP1945613A1
公开(公告)日：2008-07-23
申请号：EP06812951.9
申请日：2006-10-31
申请人： AstraZeneca AB
发明人： HEMMERLING, Martin , HOSSAIN, Nafizal , IVANOVA, Svetlana , MUSSIE, Tesfaledet , SHAMOVSKY, Igor , SJÖHOLM Timèn, Åsa
IPC分类号： C07D211/58 , A61K31/4468 , A61K31/454 , A61P11/00 , A61P11/06 , C07D401/12
CPC分类号： C07D211/58 , C07D211/72 , C07D401/12
摘要： The invention provides 1 -benzyl- 4 -piperidinamines of the general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory diseses such as chronic obstructive pulmonary disease and asthma. The compounds are inhibitors of the CCRl receptor.
-
9.发明公开NEW PIPERIDINYL-MORPHOLINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权PIPERIDINYLMORPHOLINYLDERIVATE作为趋化因子受体的调节剂
公开(公告)号：EP1421082A1
公开(公告)日：2004-05-26
申请号：EP02760960.1
申请日：2002-08-21
申请人： AstraZeneca AB
IPC分类号： C07D413/04 , C07D413/14 , A61K31/5377 , A61P11/00 , A61P19/00 , A61P31/00 , A61P37/00
CPC分类号： C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention provides compounds of general formula (I), in which m, n, Z?1, Z2, R1, R2, R3, R4 and R5¿ are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; and their use in therapy.
-
公开(公告)号：EP2291359A1
公开(公告)日：2011-03-09
申请号：EP09750864.2
申请日：2009-05-20
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN Karl , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN, Nafizal , JOHANSSON, Henrik , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D231/56 , A61K31/416 , A61K31/422 , A61K31/4439 , A61K31/444 , A61P11/00 , A61P29/00 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: Formula (la) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.024 秒)
