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1.发明授权NOVEL (R)-5-CARBAMOYL-8-FLUORO-3-N,N-DISUBSTITUTED-AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES 失效烯丙基-8-氟-3-N，N-脱水氨基 - 氨基-3,4-二氢-2H-哒嗪-2-酮
公开(公告)号：EP0725779B1
公开(公告)日：2001-07-11
申请号：EP94931725.9
申请日：1994-10-26
申请人： AstraZeneca AB
发明人： EVENDEN, John, Leslie , HAMMARBERG, Eva, Maria , HANSSON, Hans, Sverker , HELLBERG, Sven, Erik , JOHANSSON, Lars, George , LUNDKVIST, Johan, Rune, Michael , ROSS, Svante, Bertil , SOHN, Daniel, Dungan , THORBERG, Seth, Olov
IPC分类号： C07D311/58 , A61K31/35
CPC分类号： C07D311/58 , A61K31/353 , C07D335/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
摘要： Compounds of general formula (I), wherein R1 is n-propyl or cyclobutyl; R2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R3 is hydrogen; R4 is hydrogen or methyl; as (R)-enantiomer and in the form of free base or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical composition, use of and method of treatment of disorders in CNS.
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公开(公告)号：EP3119752A1
公开(公告)日：2017-01-25
申请号：EP15713339.8
申请日：2015-03-17
申请人： Astrazeneca AB
发明人： BERGLUND, Susanne, Elisabeth , CONNOLLY, Stephen , HEMMERLING, Martin , HOSSAIN, Nafizal , KRISTOFFERSSON, Anna , LUNDKVIST, Johan, Rune, Michael , NIKITIDIS, Grigorios , RIPA, Lena, Elisabeth , SHAMOVSKY, Igor
IPC分类号： C07D401/06 , C07D241/28 , A61K31/497 , A61P11/00
CPC分类号： C07D401/12 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D241/26 , C07D241/28 , C07D401/06
摘要： The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).
摘要翻译： 本发明提供式（I）的化合物或其药学上可接受的盐; 制备这种化合物的方法; 以及在治疗ENaC介导的疾病状态（例如哮喘，CF或COPD）中使用这种化合物。
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3.发明授权3,4-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF ENAC MEDIATED DISEASES 有权3,4-二氨基-6-氯吡嗪-2-羧酰胺类化合物用于治疗ENAC介导的疾病
公开(公告)号：EP3119752B1
公开(公告)日：2018-05-16
申请号：EP15713339.8
申请日：2015-03-17
申请人： Astrazeneca AB
发明人： BERGLUND, Susanne, Elisabeth , CONNOLLY, Stephen , HEMMERLING, Martin , HOSSAIN, Nafizal , KRISTOFFERSSON, Anna , LUNDKVIST, Johan, Rune, Michael , NIKITIDIS, Grigorios , RIPA, Lena, Elisabeth , SHAMOVSKY, Igor
IPC分类号： C07D401/06 , C07D241/28 , A61K31/497 , A61P11/00
CPC分类号： C07D401/12 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D241/26 , C07D241/28 , C07D401/06
摘要： The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).
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