利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

16 条记录 (耗时 0.029 秒)

    6,7,8,9-TETRAHYDRO-5-AMINO-5H-BENZOCYCLOHEPTEN-6-OL DERIVATE UND VERWANDTE VERBINDUNGEN ALS ENTZÜNDUNGSHEMMER
    3.
    发明公开
    6,7,8,9-TETRAHYDRO-5-AMINO-5H-BENZOCYCLOHEPTEN-6-OL DERIVATE UND VERWANDTE VERBINDUNGEN ALS ENTZÜNDUNGSHEMMER 审中-公开
    -6,7,8,9-四氢-5-氨基-5H-苯并环庚-6-醇衍生物和相关化合物作为抗炎

    公开(公告)号：EP1863765A1

    公开(公告)日：2007-12-12

    申请号：EP06723721.4

    申请日：2006-03-20

    申请人： Bayer Schering Pharma Aktiengesellschaft

    发明人： REHWINKEL, Hartmut ,  NGUYEN, Duy ,  BERGER, Markus ,  SCHÄCKE, Heike

    IPC分类号： C07D211/88 ,  C07D231/56 ,  C07D403/04 ,  C07D215/22 ,  A61P29/00

    CPC分类号： C07D211/88 ,  C07D215/227 ,  C07D231/56 ,  C07D403/04

    摘要： The invention relates to polysubstituted 5H-benzocyclohepten derivatives of formula (I), in which R3 represents a C1-C10 alkyl group, which can be optionally substituted by a group selected from 1-3 hydroxy groups, halogen atoms, or 1-3 (C1-C5) alkoxy groups, an optionally substituted (C3-C7) cycloalkyl group, an optionally substituted heterocyclyl group, an optionally substituted aryl group, or other substituents, A represents a -CR6R7-CH2- or -CH2-CR6R7 group, D represents a -CR4R5-CH2- or -CH2-CR4R5 group, R4 represents a hydroxy group, an OR10 group or O(CO)R10 group, R5 represents a (C1-C5) alkyl group or an optionally partially or completely fluorinated (C1-C5) alkyl group, a (C3-C7) cycloalkyl group, a (C1-C8) alkene (C3-C7) cycloalkyl group, a (C2-C8) alkene (C3-C7) cycloalkyl group, a heterocyclyl group, a (C1-C8) alkene heterocyclyl group, a (C2-C8) alkene heterocyclyl group, an aryl group, a (C1-C8) alkene aryl group, a (C2-C8) alkenylene aryl group, a (C2-C8) alkynylene aryl group, or other substituents. Said other substituents are specified in the claims. The invention also relates to a method for producing said derivatives and to their use as anti-inflammatory agents.