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公开(公告)号：EP3363790A1
公开(公告)日：2018-08-22
申请号：EP18162983.3
申请日：2014-09-05
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan
IPC分类号： C07D271/06 , C07D285/08 , A61K31/4245 , A61K31/433
摘要： The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signaling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.
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2.发明公开
公开(公告)号：EP3267999A1
公开(公告)日：2018-01-17
申请号：EP16761174.8
申请日：2016-03-08
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D271/10 , A61K31/4245 , A61K31/454 , A61K45/06 , A61P35/00 , C07D413/04 , C07D413/06 , C07D413/12
摘要： The present invention relates to 1,3,4-oxadiazole and thiadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD-1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
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公开(公告)号：EP3267993A1
公开(公告)日：2018-01-17
申请号：EP16761170.6
申请日：2016-03-07
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan
IPC分类号： A61K31/395 , A61K31/38
CPC分类号： C07D498/04 , A61K31/24 , A61K31/395 , A61K31/40 , A61K31/4045 , A61K31/407 , A61K31/4178 , A61K45/06 , C07D273/00 , C07D413/06
摘要： The present invention relates to cyclic compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD-1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
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4.发明公开
公开(公告)号：EP3768259A2
公开(公告)日：2021-01-27
申请号：EP19767288.4
申请日：2019-03-13
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan , CHENNAKRISHINAREDDY, Gundala
IPC分类号： A61K31/4245
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公开(公告)号：EP3737401A1
公开(公告)日：2020-11-18
申请号：EP19738566.9
申请日：2019-01-11
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公开(公告)号：EP3703683A1
公开(公告)日：2020-09-09
申请号：EP18836390.7
申请日：2018-10-31
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan , GOWDA, Nagaraj
IPC分类号： A61K31/4245 , A61P31/00 , A61P35/00 , C07D273/08
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7.发明公开CYCLIC PEPTIDOMIMETIC COMPOUNDS AS IMMUNOMODULATORS 有权CYCLISCHE PEPTIDOMIMETISCHE VERBINDUNGEN ALS IMMUNMODULATOREN
公开(公告)号：EP3041468A1
公开(公告)日：2016-07-13
申请号：EP14781947.8
申请日：2014-09-05
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan
IPC分类号： A61K31/38 , A61K31/395 , C07D273/00 , C07D285/00
CPC分类号： C07K7/64 , A61K31/38 , A61K31/395 , A61K38/00 , C07D259/00 , C07D273/00 , Y02A50/385 , Y02A50/401 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/463 , Y02A50/465 , Y02A50/467 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/478 , Y02A50/479 , Y02A50/481
摘要： The present invention relates to cyclic peptidomimetic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also relates to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.
摘要翻译： 本发明涉及循环拟肽化合物作为能够抑制程序性细胞死亡1（PD1）信号通路的治疗剂。 本发明还涉及治疗剂的衍生物。 本发明还包括所述治疗剂和衍生物用于通过免疫激活治疗疾病的用途，包括抑制由于PD-1，PD-L1或PD-L2诱导的免疫抑制信号和使用它们的疗法。
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公开(公告)号：EP3363790B1
公开(公告)日：2020-02-19
申请号：EP18162983.3
申请日：2014-09-05
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan
IPC分类号： C07D271/06 , C07D285/08 , A61K31/4245 , A61K31/433 , A61P35/00 , A61P31/04 , A61P31/10 , A61P31/12
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公开(公告)号：EP3041828B1
公开(公告)日：2018-05-23
申请号：EP14842822.0
申请日：2014-09-05
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan
IPC分类号： C07D271/06 , C07D285/08 , A61K31/4245 , A61K31/433 , A61P31/00 , A61P35/00
CPC分类号： C07D285/12 , A61K31/4245 , A61K31/433 , A61K45/06 , A61P31/00 , A61P35/00 , C07D271/10
摘要： The present invention relates to 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.
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10.发明公开3-SUBSTITUTED 1,3,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS 审中-公开作为免疫调节剂的3-取代1,3,4-恶二唑和硫代二唑化合物
公开(公告)号：EP3267998A1
公开(公告)日：2018-01-17
申请号：EP16761187.0
申请日：2016-03-10
发明人： SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , PRASAD, Appukkuttan , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D271/10 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D271/113 , C07D413/04 , C07D417/04 , Y02A50/409 , Y02A50/411 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to 3-substituted 1,3,4-oxadiazole and thiadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD-1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
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