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1.发明授权
公开(公告)号：EP1227811B1
公开(公告)日：2004-01-14
申请号：EP00972764.5
申请日：2000-10-14
IPC分类号： A61K31/415 , A61P9/10
CPC分类号： A61K31/4174
摘要： The invention relates to the use of 2-imidazolyl substituted carbinols (I) and their pharmaceutically acceptable salts for the production of a medicament for the treatment or prophylaxis of ischaemic states. In (I), R1, R2 and R3 have the meanings disclosed in the claims.
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2.发明公开VERWENDUNG VON 2-IMIDAZOLYL-SUBSTITUIERTEN CARBINOLEN ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR BEHANDLUNG ODER PROPHYLAXE VON DURCH ISCHÄMISCHEN ZUSTÄNDEN 有权2-取代的咪唑，甲醇类用于生产药物治疗或预防疾病的缺血性条件使用效果
公开(公告)号：EP1227811A2
公开(公告)日：2002-08-07
申请号：EP00972764.5
申请日：2000-10-14
IPC分类号： A61K31/415 , A61P9/10
CPC分类号： A61K31/4174
摘要： The invention relates to the use of 2-imidazolyl substituted carbinols (I) and their pharmaceutically acceptable salts for the production of a medicament for the treatment or prophylaxis of ischaemic states. In (I), R1, R2 and R3 have the meanings disclosed in the claims.
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3.发明公开SUBSTITUIERTE BENZOYLGUANIDINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM SOWIE SIE ENTHALTENDES MEDIKAMENT 有权替补benzoylguanidines，工艺所周之，及其作为药物或诊断和药物含
公开(公告)号：EP1259481A1
公开(公告)日：2002-11-27
申请号：EP01900139.5
申请日：2001-01-08
发明人： WEICHERT, Andreas , ALBUS, Udo , JANSEN, Hans-Willi , KLEEMANN, Heinz-Werner , LANG, Hans-Jochen
IPC分类号： C07C279/22 , C07D233/64 , C07D249/02 , A61K31/41 , A61P9/10
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： The invention relates to benzoylguanidines of formula (I), wherein R2 stands for -Y-p-(C6H4)-R11, -Y-m-(C6-H4)-R11 or -Y-o-(C6H4)-R11; R11 represents (C1-C9)-heteroaryl, which is bonded by C or N and is substituted or unsubstituted with 1 to 3 substituents selected from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxy, amino, methylamino, dimethylamino and benzyl; Y represents oxygen, -S- or NR12; R12 represents H or (C1-C4)-alkyl; R4 F, Cl, Br, I or C1-C4-alkyl; R1 and R3 are defined as per the claims. Said benzoylguanidines are suitable for use as anti-arrhythmic medicaments containing cardioprotective components for the prophylaxis and treatment of infarcts and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes associated with the origination of defects caused by ischaemia, in particular during the triggering of ischaemically induced cardiac arrhythmia.
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4.发明公开HETEROCYCLISCH SUBSTITUIERTE BENZOYLGUANIDINE UND IHRE VERWENDUNG ALS NHE-INHIBITOREN 审中-公开杂环取代benzoylguanidines及其作为NHE抑制剂
公开(公告)号：EP1226124A1
公开(公告)日：2002-07-31
申请号：EP00966135.6
申请日：2000-10-07
发明人： WEICHERT, Andreas , ALBUS, Udo , JANSEN, Hans-Willi , KLEEMANN, Heinz-Werner , LANG, Hans-Jochen
IPC分类号： C07D233/54 , C07D235/06 , A61K31/4164 , A61P9/00
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The invention relates to heterocyclically substituted benzoylguanidine of formula (I), wherein the substituents R(1) to R(4) have the meanings given in the claims. These compounds (I) are suitable for use as anti-arrhythmic medicaments containing a cardio-protective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris. The benyozlguanadines also preventively inhibit the pathophysiological processes arising from ischaemically induced traumas, in particular during the triggering of ischaemically induced cardiac arrhythmia.
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5.发明公开VERWENDUNG VON 2-AMINO-3,4-DIHYDRO-CHINAZOLINEN ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR BEHANDLUNG ODER PROPHYLAXE VON ISCHÄMISCHEN ZUSTÄNDEN 有权2-氨基-3,4-二氢喹唑啉用于生产药物中的缺血性疾病的治疗或预防
公开(公告)号：EP1244454A2
公开(公告)日：2002-10-02
申请号：EP00966165.3
申请日：2000-10-14
IPC分类号： A61K31/517
CPC分类号： A61K31/517
摘要： The invention relates to the use of 2-amino-3,4-dihydro-quinazolines of formula (I) and to their pharmaceutically compatible salts for producing a medicament for treating and preventing ischaemic conditions. R1, R2 and R3 have the meanings given in the claims.
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