-
1.发明公开IMIDAZOLDERIVATE MIT BIPHENYLSULFONYLSUBSTITUTION, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM 有权有BIPHENYLSULFONYLSUBSTITUTION，PROCESS FOR THEIR咪唑衍生物，它们作为药物或诊断
公开(公告)号：EP1097141A1
公开(公告)日：2001-05-09
申请号：EP99938222.9
申请日：1999-07-10
发明人： KLEEMANN, Heinz-Werner , LANG, Hans, Jochen , SCHWARK, Jan-Robert , PETRY, Stefan , WEICHERT, Andreas
IPC分类号： C07D233/70 , C07D233/88 , A61K31/4164
CPC分类号： C07D233/70 , C07D233/88
摘要： The invention relates to compounds of formula (I), wherein the symbols have the meanings indicated in the specification. The inventive compounds exhibit dramatic antiarrhythmic proprieties and contain a cardioprotective compound. They can preventively inhibit or strongly reduce pathophysiologic processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
-
2.发明公开IMIDAZOLDERIVATE MIT BIPHENYLSULFONYLSUBSTITUTION, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM SOWIE SIE ENTHALTENDES MEDIKAMENT 有权有BIPHENYLSULFONYLSUBSTITUTION，工艺所周之，及其作为药物或诊断和药物含咪唑衍生物
公开(公告)号：EP1097140A2
公开(公告)日：2001-05-09
申请号：EP99934669.5
申请日：1999-07-10
发明人： KLEEMAN, Heinz-Werner , LANG, Hans, Jochen , SCHWARK, Jan-Robert , WEICHERT, Andreas , PETRY, Stefan
IPC分类号： C07D233/70 , C07D233/68 , C07D233/54 , A61K31/415
CPC分类号： C07D233/32 , A01N1/02 , A01N1/0205
摘要： The invention relates to compounds represented by formula (I), wherein the symbols have the meanings indicated in the description, which exhibit outstanding antiarrhythmic properties and comprise a cardioprotective component. The inventive compounds can preventively inhibit or strongly reduce pathophysiological processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
-
公开(公告)号：EP1341754B1
公开(公告)日：2004-12-08
申请号：EP01994713.4
申请日：2001-11-24
发明人： WEICHERT, Andreas , JANSEN, Hans-Willi , KLEEMANN, Heinz-Werner , LANG, Hans-Jochen , RÜTTEN, Hartmut
IPC分类号： C07C311/39 , C07D213/42 , C07D307/52 , C07D333/20 , A61K31/18 , A61P9/10 , A61P25/28 , A61P35/00
CPC分类号： C07D213/42 , C07C311/39 , C07D307/52 , C07D333/20
摘要： The invention relates to anthranilic acids of formula (I) wherein the substituents R1-R3 have the designations cited in the claims. Said acids have no unwanted and detrimental salidiuretic properties, but rather very good cardioprotective properties, for example in terms of oxygen deficiency phenomena. Due to their pharmacological properties, said acids are highly suitable as cardioprotective pharmaceuticals for the prophylaxis and treatment of infarction, as well as the treatment of angina pectoris, also preventively inhibiting or strongly reducing the pathophysiological processes in the case of disorders caused by ischaemia. The protective action of the inventive compounds of formula (I) against pathological, hypoxic and ischaemic situations, and the inhibition of the cellular Na+/HCO3 cotransporter (NBC), enables said compounds to be used as pharmaceuticals for treating all acute or chronic disorders caused by ischaemia, or diseases induced in a primary or secondary manner by said disorders.
-
4.发明公开SUBSTITUIERTE BENZOYLGUANIDINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM SOWIE SIE ENTHALTENDES MEDIKAMENT 有权替补benzoylguanidines，工艺所周之，及其作为药物或诊断和药物含
公开(公告)号：EP1259481A1
公开(公告)日：2002-11-27
申请号：EP01900139.5
申请日：2001-01-08
发明人： WEICHERT, Andreas , ALBUS, Udo , JANSEN, Hans-Willi , KLEEMANN, Heinz-Werner , LANG, Hans-Jochen
IPC分类号： C07C279/22 , C07D233/64 , C07D249/02 , A61K31/41 , A61P9/10
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： The invention relates to benzoylguanidines of formula (I), wherein R2 stands for -Y-p-(C6H4)-R11, -Y-m-(C6-H4)-R11 or -Y-o-(C6H4)-R11; R11 represents (C1-C9)-heteroaryl, which is bonded by C or N and is substituted or unsubstituted with 1 to 3 substituents selected from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxy, amino, methylamino, dimethylamino and benzyl; Y represents oxygen, -S- or NR12; R12 represents H or (C1-C4)-alkyl; R4 F, Cl, Br, I or C1-C4-alkyl; R1 and R3 are defined as per the claims. Said benzoylguanidines are suitable for use as anti-arrhythmic medicaments containing cardioprotective components for the prophylaxis and treatment of infarcts and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes associated with the origination of defects caused by ischaemia, in particular during the triggering of ischaemically induced cardiac arrhythmia.
-
5.发明公开HETEROCYCLISCH SUBSTITUIERTE BENZOYLGUANIDINE UND IHRE VERWENDUNG ALS NHE-INHIBITOREN 审中-公开杂环取代benzoylguanidines及其作为NHE抑制剂
公开(公告)号：EP1226124A1
公开(公告)日：2002-07-31
申请号：EP00966135.6
申请日：2000-10-07
发明人： WEICHERT, Andreas , ALBUS, Udo , JANSEN, Hans-Willi , KLEEMANN, Heinz-Werner , LANG, Hans-Jochen
IPC分类号： C07D233/54 , C07D235/06 , A61K31/4164 , A61P9/00
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The invention relates to heterocyclically substituted benzoylguanidine of formula (I), wherein the substituents R(1) to R(4) have the meanings given in the claims. These compounds (I) are suitable for use as anti-arrhythmic medicaments containing a cardio-protective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris. The benyozlguanadines also preventively inhibit the pathophysiological processes arising from ischaemically induced traumas, in particular during the triggering of ischaemically induced cardiac arrhythmia.
-
6.发明公开SUBSTITUIERTE SULFONYLCYANAMIDE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS MEDIKAMENT 有权取代SULFONYLCYANAMIDE，用于生产及其作为药物
公开(公告)号：EP1076651A1
公开(公告)日：2001-02-21
申请号：EP99948554.3
申请日：1999-04-30
发明人： WEICHERT, Andreas , LANG, Hans, Jochen , PETRY, Stefan , SCHWARK, Jan-Robert , KLEEMANN, Heinz-Werner , FABER, Sabine , JANSEN, Hans-Willi
IPC分类号： C07D233/90 , C07D233/68 , A61K31/415
CPC分类号： C07D233/90 , C07C311/16 , C07D233/68
摘要： The invention relates to compounds of formula (I) in which the symbols have the meanings given in the claims. Said compounds are inhibitors of the sodium-dependent bicarbonate/chloride ion exchanger which can be used as medicines for the prophylaxis or treatment of a wide range of diseases, for example the treatment and/or prophylaxis of myocardial infarction, angina pectoris, diseases caused by ischaemia, impaired respiration, cardiac ischaemia, ischaemia of the peripheral and central nervous system and stroke, ischaemia of the peripheral organs and limbs and diseases in which cell proliferation is a primary or secondary cause, in the treatment of shock, during surgical interventions and organ transplants or for preserving and storing transplants to be used in surgical interventions.
-
7.发明公开BIPHENYLSULFONYLCYANAMIDE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS MEDIKAMENT 有权BIPHENYLSULFONYLCYANAMIDE，生产方法及其作为药物
公开(公告)号：EP1053224A1
公开(公告)日：2000-11-22
申请号：EP99913138.6
申请日：1999-02-04
发明人： KLEEMANN, Heinz-Werner , LANG, Hans-Jochen , SCHWARK, Jan-Robert , WEICHERT, Andreas , FABER, Sabine , JANSEN, Hans-Willi , PETRY, Stefan
IPC分类号： C07C311/46 , C07C311/37 , C07D333/24 , C07D333/60 , C07D209/18 , A61K31/18
CPC分类号： C07C311/47 , C07C311/37 , C07C311/46 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10
摘要： The invention relates to compounds of formula (I) in which the symbols have the meanings given in the description. The compounds have excellent antiarrhythmic properties and comprise a cardioprotective component. The inventive compounds can preventively inhibit or strongly reduce the pathophysiological processes when ischaemic induced damages arise, especially during the onset of ischaemic induced cardiac arrhythmias. In addition, the inventive compounds have a strong inhibiting effect on the proliferation of cells.
-
8.发明公开VERWENDUNG VON 2-AMINO-3,4-DIHYDRO-CHINAZOLINEN ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR BEHANDLUNG ODER PROPHYLAXE VON ISCHÄMISCHEN ZUSTÄNDEN 有权2-氨基-3,4-二氢喹唑啉用于生产药物中的缺血性疾病的治疗或预防
公开(公告)号：EP1244454A2
公开(公告)日：2002-10-02
申请号：EP00966165.3
申请日：2000-10-14
IPC分类号： A61K31/517
CPC分类号： A61K31/517
摘要： The invention relates to the use of 2-amino-3,4-dihydro-quinazolines of formula (I) and to their pharmaceutically compatible salts for producing a medicament for treating and preventing ischaemic conditions. R1, R2 and R3 have the meanings given in the claims.
-
9.发明授权BIPHENYLSULFONYLCYANAMIDE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS MEDIKAMENT 有权联苯磺酰甲酰胺，VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS MEDIKAMENT
公开(公告)号：EP1053224B1
公开(公告)日：2002-08-21
申请号：EP99913138.6
申请日：1999-02-04
发明人： KLEEMANN, Heinz-Werner , LANG, Hans-Jochen , SCHWARK, Jan-Robert , WEICHERT, Andreas , FABER, Sabine , JANSEN, Hans-Willi , PETRY, Stefan
IPC分类号： C07C311/46 , C07C311/37 , C07D333/24 , C07D333/60 , C07D209/18 , A61K31/18
CPC分类号： C07C311/47 , C07C311/37 , C07C311/46 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10
摘要： The invention relates to compounds of formula (I) in which the symbols have the meanings given in the description. The compounds have excellent antiarrhythmic properties and comprise a cardioprotective component. The inventive compounds can preventively inhibit or strongly reduce the pathophysiological processes when ischaemic induced damages arise, especially during the onset of ischaemic induced cardiac arrhythmias. In addition, the inventive compounds have a strong inhibiting effect on the proliferation of cells.
摘要翻译： 本发明涉及式（I）化合物，其中符号具有以下含义：R（1）为1。 具有1,2,3,4,5,6,7或8个碳原子的烷基; 2。 具有1,2,3,4,5,6,7或8个碳原子的烷基，其中全部氢原子被氟取代; 3。 具有2个，3个，4个，5个，6个，7个，8个，9个，10个，11个或12个碳原子的链烯基; 或4。 -CnH2n-nn-Y，nn为0或2; andn为零，1,2,3或4; 其中n不等于零，如果n n等于2，则为1; 5。 -CnH2n-nn-Y，nn为0或2; andn是1,2,3或4; 如果n n等于2，则n不等于1。
-
10.发明公开GALLENSAUER SUBSTITUIERTE PHENYL-ALKENOYLGUANIDINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENTE ODER DIAGNOSTIKA SOWIE SIE ENTHALTENDES MEDIKA 有权GALLEN奥尔取代的苯基ALKENOYLGUANIDINE，PROCESS FOR THEIR，它们的使用药物或诊断和含有MEDIKA
公开(公告)号：EP1124841A1
公开(公告)日：2001-08-22
申请号：EP99949001.4
申请日：1999-10-15
发明人： WEICHERT, Andreas , ENHSEN, Alfons , FALK, Eugen , JANSEN, Hans-Willi , KRAMER, Werner , SCHWARK, Jan-Robert , LANG, Hans, Jochen
IPC分类号： C07J41/00 , A61K31/575 , C07J9/00
CPC分类号： C07J41/0055 , C07J9/005 , C07J41/0061
摘要： The invention relates to substituted phenyl alkenoyl guanidines, the pharmaceutically acceptable salts thereof, and physiolgically functional derivatives. Compounds of formula (I) are disclosed, wherein the radicals have the meanings thus cited. Also disclosed are the physiologically acceptable salts thereof, physiologically functional derivatives and methods for the production thereof. The inventive compounds are, for instance, suitable for use as medicaments for the prophylaxis or treatment of gall stones.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.022 秒)
