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1.发明公开PLURAFLAVINS AND DERIVATIVES THEREOF, PROCESS FOR THEIR PREPARATION AND USE THEREOF 有权Pluraflavins及其衍生物，用于生产及其用途
公开(公告)号：EP1259523A2
公开(公告)日：2002-11-27
申请号：EP01915255.2
申请日：2001-02-15
发明人： VERTESY, Laszlo , EHRLICH, Klaus , KNAUF, Martin , WINK, Joachim , BARBONE, Francis, P. , POWERS, Elaine, A. , CASHMAN, Elizabeth, A.
摘要： The invention relates to a compound of formula (I) wherein R1 is a sugar; R2 is -CH2-O-(R7)m, R7 representing a sugar, or R2 is -COOH; R3 is an epoxide-comprising group, C1-C6-alkyl or C2-C6-alkenyl, unsubstituted or substituted by at least one OH; R5 is H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; R4, R6, R8 and R10 independently of one another are H,C1-C6-alkyl, C2-C6-alkenyl, C2-C6-Alkynyl, -X2H, or -X2R12, or R4 and R6 together and/or R8 and R10 together are =X2; X2 is O, NH, N-C1-C6-alkyl, N-C2-C6-alkenyl, N-C2-C6-alkynyl or S; R12 is C1-C6-Alkenyl, C2-C6-alkynyl, C2-C6-alkynyl, aryl or acyl; and m and n are 1 or 2; and its physiologically acceptable salts. The compounds are obtainable from a culture of the microorganism Actinomycetales species HAG 003959, DSM 12931, by fermentation. Accordingly, the invention relates to a process for their preparation and to the use of the compounds as pharmaceuticals, for example as anti-tumor agents.
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2.发明公开GABUSECTIN-DERIVATE, VERFAHREN ZUR DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权Gabusectin衍生物，其制备方法及其用途
公开(公告)号：EP1448522A1
公开(公告)日：2004-08-25
申请号：EP02803357.9
申请日：2002-11-07
IPC分类号： C07D207/44
CPC分类号： C07D207/44
摘要： The invention relates to compounds of formula (I) which are formed by the micro-organism ST 003236 (DSM 14476) during fermentation. The invention also relates to a method for producing said compounds and to the derivation thereof, to pharmaceuticals containing a compound of formula (I) and to the use of the same for producing a pharmaceutical.
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3.发明授权PLURAFLAVINS AND DERIVATIVES THEREOF, PROCESS FOR THEIR PREPARATION AND USE THEREOF 有权Pluraflavins及其衍生物，用于生产及其用途
公开(公告)号：EP1259523B1
公开(公告)日：2003-11-26
申请号：EP01915255.2
申请日：2001-02-15
发明人： VERTESY, Laszlo , EHRLICH, Klaus , KNAUF, Martin , WINK, Joachim , BARBONE, Francis, P. , POWERS, Elaine, A. , CASHMAN, Elizabeth, A.
摘要： The invention relates to a compound of formula (I) wherein R1 is a sugar; R2 is -CH2-O-(R7)m, R7 representing a sugar, or R2 is -COOH; R3 is an epoxide-comprising group, C1-C6-alkyl or C2-C6-alkenyl, unsubstituted or substituted by at least one OH; R5 is H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; R4, R6, R8 and R10 independently of one another are H,C1-C6-alkyl, C2-C6-alkenyl, C2-C6-Alkynyl, -X2H, or -X2R12, or R4 and R6 together and/or R8 and R10 together are =X2; X2 is O, NH, N-C1-C6-alkyl, N-C2-C6-alkenyl, N-C2-C6-alkynyl or S; R12 is C1-C6-Alkenyl, C2-C6-alkynyl, C2-C6-alkynyl, aryl or acyl; and m and n are 1 or 2; and its physiologically acceptable salts. The compounds are obtainable from a culture of the microorganism Actinomycetales species HAG 003959, DSM 12931, by fermentation. Accordingly, the invention relates to a process for their preparation and to the use of the compounds as pharmaceuticals, for example as anti-tumor agents.
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4.发明公开HYDROXYPHENYLUNDECANE DERIVATES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE 审中-公开HYDROXYPHENYLUNDECAN苯乙烯衍生物，其制备方法及其用途
公开(公告)号：EP1556333A1
公开(公告)日：2005-07-27
申请号：EP03750570.8
申请日：2003-09-18
IPC分类号： C07C69/88 , C07C305/24 , C12P7/62 , C12P11/00 , C12R1/645 , A61K31/235 , A61K31/095 , A61P25/00
CPC分类号： C07C69/88 , C07C305/24 , C12P7/6436 , C12R1/645
摘要： The present invention relates to novel hydroxyphenyludecane derivatives of the formula (I), a method for the preparation of said compounds by cultivation of the fungus Cryphonectria parasitica, DSM 14453, and their use as pharmaceuticals, i.e. for the treatment of Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Diseases, stroke, psychosis and/or depressions.
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5.发明公开CONIOSETIN UND DERIVATE DAVON, VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DERSELBEN 有权Coniosetin及其衍生物，用于生产及其用途
公开(公告)号：EP1341758A2
公开(公告)日：2003-09-10
申请号：EP01989546.5
申请日：2001-11-30
发明人： VERTESY, LASZLO , KNAUF, Martin , MARKUS, Astrid , TOTI, Luigi , RAYNAL-WETZEL, Mark-Cécile , FASSY, Florence
IPC分类号： C07D207/44 , A61K31/4015 , A61P31/04 , A61P31/10
CPC分类号： C07D207/44
摘要： The invention relates to novel active agents (coniosetin and coniosetin derivatives) of formula I, which are produced by the micro-organism Coniochaeta ellipsoidea Udagawa (DSM 13856) during fermentation, R, R2, R3, R4, R5, X, X2, X3 and X4 having the meanings given. The invention also relates to chemical derivatives of coniosetin, to a method for producing them and to the use of the same as medicaments.
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