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1.发明公开VERWENDUNG VON INHIBITOREN DES KQT1-KANALS ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR BEHANDLUNG VON KRANKHEITEN, DIE DURCH HELMINTHEN UND EKTOPARASITEN HERVORGERUFEN WERDEN 有权KQT1 CHANNEL抑制剂用于制造药物疾病的治疗中，BY THEN希勒米和体外寄生虫，OUT所产生USE
公开(公告)号：EP1140042A1
公开(公告)日：2001-10-10
申请号：EP99958170.5
申请日：1999-12-07
发明人： GERLACH, Uwe , HOFMANN, Joachim , LANG, Hans, Jochen , WEI, AguanWashington Uni. School of Medicine
IPC分类号： A61K31/00 , A61K31/353 , A61K31/18 , A61K31/4433 , A61K31/352 , A01N43/16 , A61P33/10 , A61P33/14
CPC分类号： A61K31/4433 , A61K31/00 , A61K31/18 , A61K31/352 , A61K31/353
摘要： The invention relates to the utilization of inhibitors of the KQT1 channel in order produce a medicament for treating diseases which are caused by parasitic helminths and ectoparasites. According to the invention, inhibitors of the KQT1 channel depict a novel lethal fundamental constituent for parasitic helminths and ectoparasites. Blockers of the cellular KQT1 channel, said channel occurring in the parasitic helminths and ectoparasites, are therefore used to produce a medicament for treating vertebrates and humans which are afflicted with the parasitic helminths or ectoparasites. These KQT1 blockers are used alone as medicaments or in combination with other medicaments and therapeutic measures. Inhibitors of the KQT1 channel also depict a novel working mechanism for plant pests such as insects, spiders, mollusks and nematoda, and are consequently used in order to produce a plant protective agent.
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