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1.发明公开SUBSTITUIERTE SULFONYLCYANAMIDE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS MEDIKAMENT 有权取代SULFONYLCYANAMIDE，用于生产及其作为药物
公开(公告)号：EP1076651A1
公开(公告)日：2001-02-21
申请号：EP99948554.3
申请日：1999-04-30
发明人： WEICHERT, Andreas , LANG, Hans, Jochen , PETRY, Stefan , SCHWARK, Jan-Robert , KLEEMANN, Heinz-Werner , FABER, Sabine , JANSEN, Hans-Willi
IPC分类号： C07D233/90 , C07D233/68 , A61K31/415
CPC分类号： C07D233/90 , C07C311/16 , C07D233/68
摘要： The invention relates to compounds of formula (I) in which the symbols have the meanings given in the claims. Said compounds are inhibitors of the sodium-dependent bicarbonate/chloride ion exchanger which can be used as medicines for the prophylaxis or treatment of a wide range of diseases, for example the treatment and/or prophylaxis of myocardial infarction, angina pectoris, diseases caused by ischaemia, impaired respiration, cardiac ischaemia, ischaemia of the peripheral and central nervous system and stroke, ischaemia of the peripheral organs and limbs and diseases in which cell proliferation is a primary or secondary cause, in the treatment of shock, during surgical interventions and organ transplants or for preserving and storing transplants to be used in surgical interventions.
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2.发明公开IMIDAZOLDERIVATE MIT BIPHENYLSULFONYLSUBSTITUTION, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM 有权有BIPHENYLSULFONYLSUBSTITUTION，PROCESS FOR THEIR咪唑衍生物，它们作为药物或诊断
公开(公告)号：EP1097141A1
公开(公告)日：2001-05-09
申请号：EP99938222.9
申请日：1999-07-10
发明人： KLEEMANN, Heinz-Werner , LANG, Hans, Jochen , SCHWARK, Jan-Robert , PETRY, Stefan , WEICHERT, Andreas
IPC分类号： C07D233/70 , C07D233/88 , A61K31/4164
CPC分类号： C07D233/70 , C07D233/88
摘要： The invention relates to compounds of formula (I), wherein the symbols have the meanings indicated in the specification. The inventive compounds exhibit dramatic antiarrhythmic proprieties and contain a cardioprotective compound. They can preventively inhibit or strongly reduce pathophysiologic processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
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3.发明公开IMIDAZOLDERIVATE MIT BIPHENYLSULFONYLSUBSTITUTION, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM SOWIE SIE ENTHALTENDES MEDIKAMENT 有权有BIPHENYLSULFONYLSUBSTITUTION，工艺所周之，及其作为药物或诊断和药物含咪唑衍生物
公开(公告)号：EP1097140A2
公开(公告)日：2001-05-09
申请号：EP99934669.5
申请日：1999-07-10
发明人： KLEEMAN, Heinz-Werner , LANG, Hans, Jochen , SCHWARK, Jan-Robert , WEICHERT, Andreas , PETRY, Stefan
IPC分类号： C07D233/70 , C07D233/68 , C07D233/54 , A61K31/415
CPC分类号： C07D233/32 , A01N1/02 , A01N1/0205
摘要： The invention relates to compounds represented by formula (I), wherein the symbols have the meanings indicated in the description, which exhibit outstanding antiarrhythmic properties and comprise a cardioprotective component. The inventive compounds can preventively inhibit or strongly reduce pathophysiological processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
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4.发明授权POLYCYCLISCHE 2-AMINO-DIHYDROTHIAZOLSYSTEME, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权多环芳烃2-氨基DIHYDROTHIAZOLSYSTEME，其制造方法相同，它们作为药物
公开(公告)号：EP1157014B1
公开(公告)日：2005-08-24
申请号：EP00907504.5
申请日：2000-02-05
IPC分类号： C07D277/60 , C07D277/84 , C07D417/04 , A61K31/428 , A61P3/04 , A61P3/10
CPC分类号： C07D277/60
摘要： The invention relates to polycyclic 2-amino-dihydrothiazole systems, their physiologically acceptable salts and physiologically functional derivatives. The invention describes compounds of formula (I), wherein the radicals have the cited meaning, their physiologically acceptable salts and a method for the production thereof. Said compounds are suitable, for example, as anoretics.
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5.发明公开VERWENDUNG VON INHIBITOREN DES KQT1-KANALS ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR BEHANDLUNG VON KRANKHEITEN, DIE DURCH HELMINTHEN UND EKTOPARASITEN HERVORGERUFEN WERDEN 有权KQT1 CHANNEL抑制剂用于制造药物疾病的治疗中，BY THEN希勒米和体外寄生虫，OUT所产生USE
公开(公告)号：EP1140042A1
公开(公告)日：2001-10-10
申请号：EP99958170.5
申请日：1999-12-07
发明人： GERLACH, Uwe , HOFMANN, Joachim , LANG, Hans, Jochen , WEI, AguanWashington Uni. School of Medicine
IPC分类号： A61K31/00 , A61K31/353 , A61K31/18 , A61K31/4433 , A61K31/352 , A01N43/16 , A61P33/10 , A61P33/14
CPC分类号： A61K31/4433 , A61K31/00 , A61K31/18 , A61K31/352 , A61K31/353
摘要： The invention relates to the utilization of inhibitors of the KQT1 channel in order produce a medicament for treating diseases which are caused by parasitic helminths and ectoparasites. According to the invention, inhibitors of the KQT1 channel depict a novel lethal fundamental constituent for parasitic helminths and ectoparasites. Blockers of the cellular KQT1 channel, said channel occurring in the parasitic helminths and ectoparasites, are therefore used to produce a medicament for treating vertebrates and humans which are afflicted with the parasitic helminths or ectoparasites. These KQT1 blockers are used alone as medicaments or in combination with other medicaments and therapeutic measures. Inhibitors of the KQT1 channel also depict a novel working mechanism for plant pests such as insects, spiders, mollusks and nematoda, and are consequently used in order to produce a plant protective agent.
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6.发明授权POLYCYCLISCHE THIAZOLIDIN-2-YLIDEN AMINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权多环芳烃噻唑烷-2-亚基AMINES，其制造方法相同，它们作为药物
公开(公告)号：EP1098891B1
公开(公告)日：2005-08-10
申请号：EP99934568.9
申请日：1999-07-03
发明人： JÄHNE, Gerhard , GEISEN, Karl , LANG, Hans, Jochen
IPC分类号： C07D277/60 , C07D513/04 , A61K31/428 , A61K31/429 , C07D417/04
CPC分类号： C07D277/60 , C07D417/04 , C07D513/04
摘要： The invention relates to polycyclic thiazolidin-2-ylidene amines and the physiologically acceptable salts and physiologically functional derivatives thereof. Disclosed are polycyclic thiazolidin-2-ylidene amines of formula (I), wherein the radicals mentioned have the meanings as cited. The invention also relates to the physiologically acceptable salts and to a method of production thereof. The compounds can be used as anoretics.
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7.发明公开GALLENSAUER SUBSTITUIERTE PHENYL-ALKENOYLGUANIDINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENTE ODER DIAGNOSTIKA SOWIE SIE ENTHALTENDES MEDIKA 有权GALLEN奥尔取代的苯基ALKENOYLGUANIDINE，PROCESS FOR THEIR，它们的使用药物或诊断和含有MEDIKA
公开(公告)号：EP1124841A1
公开(公告)日：2001-08-22
申请号：EP99949001.4
申请日：1999-10-15
发明人： WEICHERT, Andreas , ENHSEN, Alfons , FALK, Eugen , JANSEN, Hans-Willi , KRAMER, Werner , SCHWARK, Jan-Robert , LANG, Hans, Jochen
IPC分类号： C07J41/00 , A61K31/575 , C07J9/00
CPC分类号： C07J41/0055 , C07J9/005 , C07J41/0061
摘要： The invention relates to substituted phenyl alkenoyl guanidines, the pharmaceutically acceptable salts thereof, and physiolgically functional derivatives. Compounds of formula (I) are disclosed, wherein the radicals have the meanings thus cited. Also disclosed are the physiologically acceptable salts thereof, physiologically functional derivatives and methods for the production thereof. The inventive compounds are, for instance, suitable for use as medicaments for the prophylaxis or treatment of gall stones.
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8.发明公开POLYCYCLISCHE THIAZOLIDIN-2-YLIDEN AMINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权多环芳烃噻唑烷-2-亚基AMINES，其制造方法相同，它们作为药物
公开(公告)号：EP1098891A1
公开(公告)日：2001-05-16
申请号：EP99934568.9
申请日：1999-07-03
发明人： JÄHNE, Gerhard , GEISEN, Karl , LANG, Hans, Jochen
IPC分类号： C07D277/60 , C07D513/04 , A61K31/428 , A61K31/429 , C07D417/04
CPC分类号： C07D277/60 , C07D417/04 , C07D513/04
摘要： The invention relates to polycyclic thiazolidin-2-ylidene amines and the physiologically acceptable salts and physiologically functional derivatives thereof. Disclosed are polycyclic thiazolidin-2-ylidene amines of formula (I), wherein the radicals mentioned have the meanings as cited. The invention also relates to the physiologically acceptable salts and to a method of production thereof. The compounds can be used as anoretics.
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9.发明授权VERWENDUNG VON INHIBITOREN DES ZELLULÄREN Na+ /H+ -EXCHANGERS (NHE) ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR NORMALISIERUNG DER SERUMLIPIDE 失效作者细胞Na + / H + -EXCHANGERS（NHE）抑制剂用于生产一种药物，用于归一化血清脂质USE
公开(公告)号：EP0918515B1
公开(公告)日：2005-04-27
申请号：EP97923937.3
申请日：1997-05-20
发明人： LANG, Hans, Jochen , JANSEN, Hans-Willi , SCHWARK, Jan-Robert , KLEEMANN, Heinz-Werner , JUNG, Oliver , SCHÄFER, Hans-Ludwig , LINZ, Wolfgang , KRAMER, Werner , SCHÖLKENS, Bernward , FALK, Eugen
IPC分类号： A61K31/155 , A61K31/455 , A61K31/22 , A61K45/00 , A61K45/06 , A61P3/06
CPC分类号： A61K31/166 , A61K31/00 , A61K31/155 , A61K31/22 , A61K31/365 , A61K31/165 , A61K2300/00
摘要： The active substances identified as inhibitors of the cellular Na+/H+ exchanger (NHE) are used to prepare a medicament for normalizing serum lipids. They are used in the preparation of a medicament which reduces lipid levels in the blood and can be administered for treating diseases caused by lipid levels which are too high, and for alleviating the endothelial dysfunctional syndrome and for treating diseases caused thereby.
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10.发明授权SUBSTITUIERTE SULFONYLCYANAMIDE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS MEDIKAMENT 有权取代SULFONYLCYANAMIDE，用于生产及其作为药物
公开(公告)号：EP1076651B1
公开(公告)日：2005-04-20
申请号：EP99948554.3
申请日：1999-04-30
发明人： WEICHERT, Andreas , LANG, Hans, Jochen , PETRY, Stefan , SCHWARK, Jan-Robert , KLEEMANN, Heinz-Werner , FABER, Sabine , JANSEN, Hans-Willi
IPC分类号： C07D233/90 , C07D233/68 , A61K31/415
CPC分类号： C07D233/90 , C07C311/16 , C07D233/68
摘要： The invention relates to compounds of formula (I) in which the symbols have the meanings given in the claims. Said compounds are inhibitors of the sodium-dependent bicarbonate/chloride ion exchanger which can be used as medicines for the prophylaxis or treatment of a wide range of diseases, for example the treatment and/or prophylaxis of myocardial infarction, angina pectoris, diseases caused by ischaemia, impaired respiration, cardiac ischaemia, ischaemia of the peripheral and central nervous system and stroke, ischaemia of the peripheral organs and limbs and diseases in which cell proliferation is a primary or secondary cause, in the treatment of shock, during surgical interventions and organ transplants or for preserving and storing transplants to be used in surgical interventions.
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