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89 条记录 (耗时 0.029 秒)

    COUMARINES SULFONATÉES, LEUR SYNTHÈSE, SUBSTRATS FLUOROGÉNIQUES RÉSULTANT D'UN GREFFAGE DE CES COUMARINES SUR DES SUCRES, LE PROCÉDÉ D'OBTENTION DE CES SUBSTRATS, AINSI QUE LEURS APPLICATIONS
    3.
    发明公开
    COUMARINES SULFONATÉES, LEUR SYNTHÈSE, SUBSTRATS FLUOROGÉNIQUES RÉSULTANT D'UN GREFFAGE DE CES COUMARINES SUR DES SUCRES, LE PROCÉDÉ D'OBTENTION DE CES SUBSTRATS, AINSI QUE LEURS APPLICATIONS 有权
    磺化香豆素，它们的合成，荧光底物FROM接枝THIS香豆素ON SUGAR，用于制备这种基材和它们的用途

    公开(公告)号：EP2619281A1

    公开(公告)日：2013-07-31

    申请号：EP11764800.6

    申请日：2011-09-16

    申请人： ETS J. Soufflet ,  Université de Strasbourg

    发明人： DREVELLE, Antoine ,  LADAME, Sylvain ,  NAJAH, Majdi ,  MAYOT, Estelle

    IPC分类号： C09K11/06 ,  C07H17/075 ,  C12Q1/34 ,  G01N21/64

    CPC分类号： C07H17/075 ,  C07H17/04 ,  C09B57/02 ,  C09K11/06 ,  C09K2211/1088 ,  C12Q1/34

    摘要： The present invention relates to sulfonated coumarins, to the synthesis thereof, to fluorogenic substrates resulting from grafting said coumarins onto sugars, to a method for preparing said substrates, and to the uses thereof. The substituted sulfonated coumarins are expressed in general formula (I), where: R
    1 is H, OH, or a substituted or unsubstituted, straight or branched C
    1 to C
    6 alkyl radical, or -COR
    4 , -COOR
    4 , or -CONHR
    4 , R
    2 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C
    1 to C
    6 alkyl radical, or -COR
    4 , -COOR
    4 , or -CONHR
    4 , R
    1 and R
    2 being capable of together forming a ring, such as a substituted or unsubstituted aryl or furan, R
    3 is H or a halogen, particularly fluorine or a substituted or unsubstituted, straight or branched C
    1 to C
    6 alkyl radical, or -COR
    4 , -COOR
    4 , or - CONHR
    4 , where R
    4 is H or a substituted or unsubstituted, straight or branched C
    1 to C
    6 alkyl radical, or a substituted or unsubstituted aryl, and M is Na or K. The substrates are prepared by grafting said coumarins with the following sugars: cellobiose, xylobiose, maltose, saccharose, glucose, xylose, galactose, arabinose, xylan, glucan, xylotriose, maltotriose, cellotriose, xylotetraose, or a mixture of some of said sugars. The invention is useful in detecting glycosidase (EC3.2.1) activity on purified or unpurified enzyme extracts, or on microorganisms or cells.

    NOUVEAUX DERIVES 5-THIO-SS-D-XYLOPYRANOSIDES, PROCEDE DE PREPARATION, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION EN THERAPEUTIQUE
    4.
    发明公开
    NOUVEAUX DERIVES 5-THIO-SS-D-XYLOPYRANOSIDES, PROCEDE DE PREPARATION, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION EN THERAPEUTIQUE 有权
    NEW 5-硫代SS-D XYLOPYRANOSIDDERIVATE，制备它们的方法和它们的药物组合物含有治疗用途

    公开(公告)号：EP1385858A1

    公开(公告)日：2004-02-04

    申请号：EP02738222.5

    申请日：2002-05-07

    申请人： LABORATOIRES FOURNIER S.A.

    发明人： BARBEROUSSE, Véronique ,  SAMRETH, Soth

    IPC分类号： C07H17/075 ,  A61K31/7048 ,  A61P7/02

    CPC分类号： C07H17/075

    摘要： The invention relates to novel compounds having formula (I) in which: R1, R2 and R3 are identical or different and each represent independently: - a (C1-C6)alkyl group, - a pyridinyl group, or a -CH2-NR4R5 group in which R4 and R5 each represent independently a hydrogen atom, a (C1-C4)alkyl group or R4 and R5 form, together with the nitrogen atom to which they are linked, a pyrrolidinyl, piperidinyl, hexahydroazepinyl, morpholinyl or piperazinyl group, provided that at least one of the R1, R2 or R3 substituents is different from the (C1-C6)alkyl group. The invention also relates to the salts, solvates and hydrates thereof, particularly those that are pharmaceutically acceptable. Said compounds are used, in particular, for treating venous circulation problems.