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1.发明授权ADENOVIRUS VECTORS FOR THE TRANSFER OF FOREIGN GENES INTO CELLS OF THE CENTRAL NERVOUS SYSTEM, PARTICULARLY IN BRAIN 失效腺病毒载体外源基因在中枢神经系统的细胞的转移，特别是在脑
公开(公告)号：EP0669987B1
公开(公告)日：2008-08-13
申请号：EP93920753.6
申请日：1993-09-17
发明人： KAHN, Axel , MALLET, Jacques , PERRICAUDET, Michel , PESCHANSKI, Marc , ROBERT, Jean-Jacques , LE GAL LA SALLE, Gildas
CPC分类号： C12N15/86 , A61K38/185 , A61K38/44 , A61K38/47 , A61K48/00 , C12N9/0006 , C12N2710/10343 , C12N2830/008 , C12Y114/16002 , C12Y302/01051
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公开(公告)号：EP1129204B1
公开(公告)日：2006-02-01
申请号：EP99971861.2
申请日：1999-11-09
申请人： Aventis Pharma S.A.
发明人： MALLET, Jacques , CORTI, Olga
CPC分类号： C12N9/0071 , A61K48/00 , C12N15/635 , C12N2799/022
摘要： The invention concerns novel compositions and methods for controlling nucleic acid expression in cells. More particularly, it concerns any nucleic acid characterised in that it comprises: a) a first region comprising a nucleic acid coding for a tetracycline (tTA)-dependent transactivator under the control of a moderate promoter; and b) a second region comprising a nucleic acid of interest under the control of tTA sensitive promoter. The invention is more particularly useful for controlling the expression of nucleic acids in the nerve cells, in vitro as well as in vivo, for example the human tyrosine hydrocyclosis.
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公开(公告)号：EP1141241B1
公开(公告)日：2008-07-23
申请号：EP00901857.3
申请日：2000-01-05
申请人： Aventis Pharma S.A.
发明人： RIDET, Jean-Luc , MALLET, Jacques
CPC分类号： C12N5/0622 , A61K9/0085 , A61K35/12 , A61K48/00
摘要： The invention provides an essentially pure preparation of human adult astrocytes, and a method of producing same. The purified astrocytes are useful for the treatment of neurodegenerative disorders or trauma to the central nervous system.
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4.发明授权ADENOVIRUS COMPRENANT UN GENE CODANT POUR LA GLUTATHION PEROXYDASE 失效ADENOVIRUS MIT GLUTATHION PEROXYDATE GENE
公开(公告)号：EP0775213B1
公开(公告)日：2005-04-20
申请号：EP95926429.2
申请日：1995-07-26
申请人： Aventis Pharma S.A.
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C12N9/0065 , C12N2710/10343 , C12Y111/01009
摘要： The present invention relates to a defective recombinant adenovirus comprising at least a DNA sequence coding for all or an active part of glutathion peroxidase or a derivative thereof. It also relates to their utilisation in therapy and to the corresponding pharmaceutical compositions.
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公开(公告)号：EP1129204A1
公开(公告)日：2001-09-05
申请号：EP99971861.2
申请日：1999-11-09
申请人： Aventis Pharma S.A.
发明人： MALLET, Jacques , CORTI, Olga
CPC分类号： C12N9/0071 , A61K48/00 , C12N15/635 , C12N2799/022
摘要： The invention concerns novel compositions and methods for controlling nucleic acid expression in cells. More particularly, it concerns any nucleic acid characterised in that it comprises: a) a first region comprising a nucleic acid coding for a tetracycline (tTA)-dependent transactivator under the control of a moderate promoter; and b) a second region comprising a nucleic acid of interest under the control of tTA sensitive promoter. The invention is more particularly useful for controlling the expression of nucleic acids in the nerve cells, in vitro as well as in vivo, for example the human tyrosine hydrocyclosis.
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公开(公告)号：EP0969875B1
公开(公告)日：2008-11-26
申请号：EP98907949.6
申请日：1998-01-16
发明人： FINIELS, Françoise , GIMENEZ-RIBOTTA, Minerva , MALLET, Jacques , PRIVAT, Alain , REVAH, Frédéric
CPC分类号： C12N15/86 , A61K38/185 , A61K48/00 , C12N2750/14143
摘要： The present invention relates to methods and compositions for delivering nucleic acids to motor neurons by administering the nucleic acids to muscle tissue. The invention relates to methods for treating pathologies of the nervous system, such as trauma and neurodegenerative diseases.
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7.发明授权
公开(公告)号：EP0752003B1
公开(公告)日：2006-03-15
申请号：EP95914389.2
申请日：1995-03-21
申请人： Aventis Pharma S.A.
发明人： BEMELMANS, Alexis , GEOFFROY, Marie-Claude , HORELLOU, Philippe , JULIEN, Jean-François , MALLET, Jacques , PERRICAUDET, Michel , ROBERT, Jean-Jacques , VIGNE, Emmanuelle
CPC分类号： A61K48/005 , A61K38/00 , A61K48/00 , C12N9/88 , C12N2799/022 , C12N2799/025 , C12N2799/027 , C12N2799/028
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8.发明授权COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION, NOTAMMENT POUR LE TRAITEMENT DES MALADIES NEURODEGENERATIVES 失效药物组合物及其在神经退行性疾病的治疗特别是在使用
公开(公告)号：EP0722496B1
公开(公告)日：2005-11-30
申请号：EP94928933.4
申请日：1994-09-29
申请人： Aventis Pharma S.A.
CPC分类号： A01N43/04 , A61K31/70 , A61K31/713 , A61K38/00 , A61K48/00 , C12N15/1135 , C12N15/86 , C12N2310/11 , C12N2310/111 , C12N2710/10343 , C12N2799/021
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公开(公告)号：EP1141241A2
公开(公告)日：2001-10-10
申请号：EP00901857.3
申请日：2000-01-05
申请人： Aventis Pharma S.A.
发明人： RIDET, Jean-Luc , MALLET, Jacques
CPC分类号： C12N5/0622 , A61K9/0085 , A61K35/12 , A61K48/00
摘要： The invention provides an essentially pure preparation of human adult astrocytes, and a method of producing same. The purified astrocytes are useful for the treatment of neurodegenerative disorders or trauma to the central nervous system.
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10.发明公开VECTEURS DERIVES DE BACULORIVUS ET UTILISATION POUR LE TRANSFERT D'ACIDES NUCLEIQUES DANS LES CELLULES NERVEUSES DES VERTEBRES 审中-公开杆状病毒衍生载体及其应用程序来NUKLEINENSÄUREN的神经细胞从脊椎动物转移
公开(公告)号：EP1100946A1
公开(公告)日：2001-05-23
申请号：EP99932958.4
申请日：1999-07-23
申请人： Aventis Pharma S.A.
发明人： SARKIS, Chamsy , MALLET, Jacques
IPC分类号： C12N15/866 , A61K48/00
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C12N2710/14143
摘要： The invention concerns novel recombinant viruses and their use for gene-transfer into nerve cells of vertebrates. The invention also concerns pharmaceutical compositions comprising said recombinant viruses. More particularly, the invention concerns novel vectors derived from baculoviruses and their use for treating diseases of the nervous system of vertebrates.
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