公开(公告)号：EP0698108B1

公开(公告)日：2001-11-28

申请号：EP94916259.8

申请日：1994-05-06

申请人： Aventis Pharma S.A.

发明人： HADDADA, Hedi ,  KLONJKOWSKI, Bernard ,  PERRICAUDET, Michel ,  VIGNE, Emmanuelle

IPC分类号： C12N15/86 ,  C12N15/26 ,  C07K14/075 ,  A61K48/00 ,  C12N7/01 ,  A61K39/235

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/55 ,  C12N2710/10343

摘要： Use of a recombinant adenovirus of animal origin containing a heterologuous DNA sequence for the preparation of a pharmaceutical composition for use in the therapeutic and/or surgical treatment of the human body.

公开(公告)号：EP0783585B1

公开(公告)日：2006-06-28

申请号：EP95932050.8

申请日：1995-09-22

申请人： Aventis Pharma S.A.

发明人： ORSINI, Cécile ,  PERRICAUDET, Michel ,  VIGNE, Emmanuelle ,  YEH, Patrice

IPC分类号： C12N15/86 ,  C07K14/075

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10362 ,  C12N2800/108

摘要： The present invention relates to new viral vectors derived from adenoviruses, their preparation and utilization in gene therapy. It relates particularly to deffective recombinant adenoviruses wherein the IVa2 gene at least is inactivated.

公开(公告)号：EP1108047A1

公开(公告)日：2001-06-20

申请号：EP99940416.3

申请日：1999-08-27

申请人： Aventis Pharma S.A.

发明人： VIGNE, Emmanuelle ,  DEDIEU, Jean-François ,  LATTA, Martine ,  YEH, Patrice ,  PERRICAUDET, Michel

IPC分类号： C12N15/86 ,  C12N15/34 ,  C12N15/43 ,  C12N15/58 ,  C12N7/01 ,  C12N9/72 ,  C07K14/075 ,  C07K14/105 ,  C07K14/78 ,  C07K14/50 ,  A61K48/00

CPC分类号： C07K14/005 ,  A61K48/00 ,  C07K14/501 ,  C07K14/78 ,  C07K2319/00 ,  C12N9/6462 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2770/32622 ,  C12N2770/32634 ,  C12N2810/40 ,  C12N2810/55 ,  C12N2810/60 ,  C12N2810/6018 ,  C12N2810/80 ,  C12N2810/851 ,  C12N2810/855 ,  C12N2810/857 ,  C12Y304/21073

摘要： Modification of internal sites of the adenovirus fiber protein and hexon protein permit effective targeting of adenovirus vectors. Accessible sites to redirect adenovirus targeting were identified. The HVR5 loop of the hexon protein and the HI loop of the fiber protein (knob) were highly permissive for the insertion of foreign protein sequences, which apparently did not impact on the viability and productivity of corresponding viruses. Accessibility and functionality of the epitope strongly depend on the size of the neighboring spacers. Other results suggest that short targeting peptides can be effectively fused to the C-terminus of the fiber protein. In a specific embodiment, a series of adenovirus vectors modified at the HVR5 site, the fiber protein HI loop, or the fiber protein C-terminus to target urokinase-type plasminogen activator receptor bearing cells were prepared. Such vectors are particularly useful for targeting the vasculature, e.g., for gene therapy of cancers or cardiovascular conditions.

公开(公告)号：EP0752003B1

公开(公告)日：2006-03-15

申请号：EP95914389.2

申请日：1995-03-21

申请人： Aventis Pharma S.A.

发明人： BEMELMANS, Alexis ,  GEOFFROY, Marie-Claude ,  HORELLOU, Philippe ,  JULIEN, Jean-François ,  MALLET, Jacques ,  PERRICAUDET, Michel ,  ROBERT, Jean-Jacques ,  VIGNE, Emmanuelle

IPC分类号： C12N15/86 ,  A61K48/00 ,  C12N15/60 ,  C12N15/12 ,  C12N7/01 ,  C12N5/10 ,  A61K39/235 ,  C12N9/88

CPC分类号： A61K48/005 ,  A61K38/00 ,  A61K48/00 ,  C12N9/88 ,  C12N2799/022 ,  C12N2799/025 ,  C12N2799/027 ,  C12N2799/028

公开(公告)号：EP0752004B1

公开(公告)日：2006-08-09

申请号：EP95914402.3

申请日：1995-03-23

申请人： Aventis Pharma S.A.

发明人： HORELLOU, Philippe ,  MALLET, Jacques ,  PERRICAUDET, Michel ,  REVAH, Frédéric ,  VIGNE, Emmanuelle

IPC分类号： C12N15/86 ,  A61K48/00 ,  C12N15/12 ,  C07K14/475 ,  C12N7/01 ,  C12N5/10 ,  A61K39/235

CPC分类号： A61K48/00 ,  A61K38/00 ,  C07K14/475 ,  C12N15/86 ,  C12N2710/10343

摘要： Recombinant adenoviruses comprising a heterologous DNA sequence coding for glial-derived neurotrophic factor (GDNF), preparation thereof, and use thereof for treating and/or preventing degenerative neurological diseases.

公开(公告)号：EP1032695A2

公开(公告)日：2000-09-06

申请号：EP98955679.0

申请日：1998-11-17

申请人： Aventis Pharma S.A.

发明人： CROUZET, Jo[l ,  ROBERT, Jean-Jacques ,  VIGNE, Emmanuelle ,  YEH, Patrice

IPC分类号： C12N15/86 ,  C12N5/10

CPC分类号： C12N15/86 ,  C12N2710/10343

摘要： The invention concerns a method for reducing recombination phenomena among nucleic acids. It also concerns the use of said method for producing defective viruses not contaminated by replication particles. The invention further concerns novel viral constructs.