公开(公告)号：EP1204675B1

公开(公告)日：2003-05-21

申请号：EP00958620.7

申请日：2000-07-26

申请人： Aventis Pharma S.A.

发明人： BACQUE, Eric ,  BARRIERE, Jean-Claude ,  DOERFLINGER, Gilles ,  DUTRUC-ROSSET, Gilles ,  PANTEL, Guy

IPC分类号： C07K7/06 ,  A61K38/05 ,  A61K38/08 ,  A61P31/04

CPC分类号： C07D498/14 ,  C07K11/02

摘要： The invention relates to derivatives of group B streptogramins of general formula (I), wherein R, R1, Ra, Rb, Rc and Rd have the meanings given in the description. Said derivatives are particularly suitable for use as antimicrobial agents, optionally coupled with at least one group A streptogramin derivative.

公开(公告)号：EP1611127A2

公开(公告)日：2006-01-04

申请号：EP04742385.0

申请日：2004-03-29

申请人： Aventis Pharma S.A.

发明人： BIGOT, Antony ,  CHEVE, Michel ,  EL AHMAD, Youssef ,  MALLERON, Jean-Luc ,  MARTIN, Jean-Paul ,  MIGNANI, Serge ,  PANTEL, Guy ,  RONAN, Baptiste ,  TABART, Michel ,  VIVIANI, Fabrice

IPC分类号： C07D409/14 ,  C07D401/06 ,  C07D413/06

CPC分类号： C07D401/06 ,  C07D409/14 ,  C07D413/06

摘要： The invention concerns 4-substituted quinoline derivatives active as antimicrobial agents, of general formula (I), wherein: X1, X2, X3, X4 and X5 respectively represent >C-R'1 to >C-R'5, or not more than one represents N; Y represents CHR, CO, CROH, CRNH2, CRF or CF2, R being hydrogen or alkyl; m is 1, 2, or 3 and n is 0, 1 or 2; Z is CH2 or Z represents O, S, SO, SO2 and, in that case, n is equal to 2; R2 represents -CO2R, -CH2CO2R, -CH2-CH2CO2R, -CH2OH or -CH2-CH2OH, R being as defined above; R3 represents phenyl, heteroaryl or alk-R°3, wherein alk is an alkyl and R°3 represents various groups, optionally oxygenated, sulphured or aminated, in their enantiomeric or diastereoisomeric forms or mixtures thereof, and optionally in their syn or anti forms or mixtures thereof, as well as their salts.

公开(公告)号：EP1204675A1

公开(公告)日：2002-05-15

申请号：EP00958620.7

申请日：2000-07-26

申请人： Aventis Pharma S.A.

发明人： BACQUE, Eric ,  BARRIERE, Jean-Claude ,  DOERFLINGER, Gilles ,  DUTRUC-ROSSET, Gilles ,  PANTEL, Guy

IPC分类号： C07K7/06 ,  A61K38/05 ,  A61K38/08 ,  A61P31/04

CPC分类号： C07D498/14 ,  C07K11/02

摘要： The invention relates to derivatives of group B streptogramins of general formula (I), wherein R, R1, Ra, Rb, Rc and Rd have the meanings given in the description. Said derivatives are particularly suitable for use as antimicrobial agents, optionally coupled with at least one group A streptogramin derivative.

摘要翻译： 本发明涉及通式（I）的B组链霉抗生物素的衍生物，其中R，R 1，R a，R b，R c和R d具有说明书中给出的含义。 所述衍生物特别适合用作抗微生物剂，任选与至少一种A组链霉素衍生物偶联。

公开(公告)号：EP1337529A2

公开(公告)日：2003-08-27

申请号：EP01996538.3

申请日：2001-11-14

申请人： Aventis Pharma S.A.

发明人： BACQU , Eric ,  CARRY, Jean-Christophe ,  EL-AHMAD, Youssef ,  EVERS, Michel ,  HUBERT, Philippe ,  MALLERON, Jean-Luc ,  MIGNANI, Serge ,  PANTEL, Guy ,  TABART, Michel ,  VIVIANI, Fabrice

IPC分类号： C07D409/14 ,  C07D401/06 ,  C07D401/14 ,  C07D417/14 ,  A61K31/47 ,  A61P31/04

CPC分类号： C07D215/20

摘要： The invention concerns heterocyclylalkyl piperidine derivatives of general formula (I), wherein X1, X2, X3, X4 and X5 are >C-R'1 to >C-R'5 or one at most represents N; R2 is COOH, alkyloxycarbonyl, cycloalkyloxycarbonyl, CN, -CONRaRb or R2 is CH2OH, alkyl substituted or R2 is -CF2-Rc, -C(CH3)2-Rc, -CO-Rc, -CHOH-Rc, -C(cycloalkyl)-Rc or -CH=CH-Rc; R3 is phenyl, heterocyclyl. alk-R°3; Y represents >CH-Re or a difluoromethylene, carbonyl, hydroxyiminomethylene, alkyloxyiminomethylene, cycloalkyloxyiminomethylene radical, or a cycloalkylene-1,1 radical; and n = 0 to 4 provided that the radicals or phenyl or heterocyclyl portions mentioned above can optionally be substituted, in the enantiomeric or diastereoisomeric forms or mixtures thereof, and/or as the case may be in their syn or anti form or mixture thereof and their salts.