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    DERIVES DE LA QUINOLYL PROPYL PIPERIDINE, LEUR PREPARATION ET LES COMPOSITIONS QUI LES CONTIENNENT
    9.
    发明公开
    DERIVES DE LA QUINOLYL PROPYL PIPERIDINE, LEUR PREPARATION ET LES COMPOSITIONS QUI LES CONTIENNENT 有权
    喹啉基丙基哌啶，生产衍生物和含你一起沉降

    公开(公告)号：EP1370550A1

    公开(公告)日：2003-12-17

    申请号：EP02722329.6

    申请日：2002-03-11

    申请人： Aventis Pharma S.A.

    发明人： BACQUE, Eric ,  MIGNANI, Serge ,  MALLERON, Jean-Luc ,  TABART, Michel ,  EVERS, Michel ,  VIVIANI, Fabrice ,  EL-AHMAD, Youssef ,  MUTTI, Stéphane ,  DAUBIE, Christophe

    IPC分类号： C07D401/06 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  A61K31/47

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14

    摘要： Quinolyl propyl piperidine deriviatives of general formula (I) wherein R1 is an H or halogen atom or OH, NH2, alkylylamino, dialkylamino, hydroxyamino, alkyloxyamino ou alkylol alkyloxy amino, R2 represents COOH, carboxymethyl or hydroxymethyl, R3 is alkyl (1 - 6 carbon atoms) substituted by phenylthio which can include 1 - 4 substituents [chosen from halogen, OH, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxy, alkyloxycarbonyl, cyano or NH2], by a cycloalkylthio radical (3 - 7 membered), or by an aromatic heterocyclylthio radical which is 5 - 6 membered comprising 1 - 4 heteroatoms chosen from nitrogen, oxygen or sulphur and itself optionally substituted [by halogen, OH, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, oxo, COOH, alkyloxycarbonyl, cyano or NH2] or R3 is propargyl substituted by phenyl which, itself, can include 1 - 4 substituents [chosen from halogen, OH, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, carboxy, alkyloxycarbonyl, CN or NH2], or substituted by cycloalkyl containing 3 -7 members or substituted by aromatic heterocyclyl (5 - 6 members and1 - 4 heteroatoms chosen from nitrogen, oxygen or sulphur) and itself optionally substituted [by halogen, OH, alkyl, alkyloxy, trifluoromethyl, trifluoromethoxy, oxo, COOH, alkyloxycarbonyl, CN or NH2], and R4 is alkyl (1 -6 carbon atoms), alkenyl-CH2- or alkynyl-CH2- (whose alkenyl or alkynyl parts comprise 2 - 6 carbon atoms), cycloalkyl or cycloalkyl alkyl (whose cycloalkyl part comprises 3 -8 carbon atoms) in the diastereoisomer forms thereof or mixtures thereof and/or in the cis or trans forms thereof, in addition to the salts thereof. The novel derivatives are particularly interesting antimicrobial agents.