专利检索 ap:("Aventis Pharma S.A.") AND inv:"SOUBRIER, Fabienne" 第 1 页

1.

发明授权
CIRCULAR DNA MOLECULE HAVING A CONDITIONAL ORIGIN OF REPLICATION, PROCESS FOR THEIR PREPARATION AND THEIR USE IN GENE THERAPY 有权
标题翻译：与条件复制起点，METHOD FOR其制造及其用途在基因治疗中的环状DNA分子

公开(公告)号：EP1549735B1

公开(公告)日：2011-08-24

申请号：EP03777599.6

申请日：2003-10-14

申请人： Aventis Pharma S.A.

发明人： SOUBRIER, Fabienne

IPC分类号： C12N1/20 , C12N15/64 , C12N15/70 , C12Q1/02

CPC分类号： C07K14/501 , A61K48/00 , C07K14/82 , C12N15/69 , C12N15/70 , C12N15/74

摘要： A prokaryotic recombinant host cell comprising a heterologous replication initiation protein that activates a conditional origin of replication and an extrachromosomal DNA molecule comprising a heterologous therapeutic gene and a conditional origin of replication whose functionality in the prokaryotic recombinant host cell requires a replication initiating protein which is foreign to the host cell is described. The host cell may comprise a pir gene having at least one mutation, which may occur in the pir gene copy number control region, the pir gene leucine zipper-like motif, or the pir gene DNA binding region.