公开(公告)号：EP2395110A1

公开(公告)日：2011-12-14

申请号：EP11003919.5

申请日：2005-12-01

申请人： Aventis Pharmaceuticals Inc.

发明人： Gruenberg, Dore ,  Huang, Xi ,  Natesan, Sridaran ,  August, Paul

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/574 ,  G01N33/6893

摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular TACC3, as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.

摘要翻译： 本发明涉及与对照相比通过测量特定遗传标志物，特别是TACC3的增加或减少来预测或监测患者对紫杉类家族分子的响应的新颖且有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白水平并将它们的水平与对照或参考标记进行比较来预测监测患者对紫杉类家族分子的反应的试剂盒。