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1.发明公开
公开(公告)号：EP2395108A1
公开(公告)日：2011-12-14
申请号：EP11003917.9
申请日：2005-12-01
发明人： Grueneberg, Dorre , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular GBP1, as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 本发明涉及新的和有用的方法的确预测或通过测量增加或特定的遗传标记的减少，特别是GBP1，监测患者对紫杉醇类分子的反应与对照相比。 因此，本发明提供试剂盒，并通过预测测量特定遗传标记的核酸或蛋白质水平和它们的水平进行比较来控制或参考标记监控患者对紫杉醇类分子反应。
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2.发明公开
公开(公告)号：EP2395102A1
公开(公告)日：2011-12-14
申请号：EP11003911.2
申请日：2005-12-01
发明人： Grueneberg, Dorre , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular MAD2L1, as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 本发明涉及新的和有用的方法的确预测或通过测量增加或特定的遗传标记的减少，特别是MAD2L1，监测患者对紫杉醇类分子的反应与对照相比。 因此，本发明提供试剂盒，并通过预测测量特定遗传标记的核酸或蛋白质水平和它们的水平进行比较来控制或参考标记监控患者对紫杉醇类分子反应。
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公开(公告)号：EP2395105A1
公开(公告)日：2011-12-14
申请号：EP11003914.6
申请日：2005-12-01
发明人： Grueneberg, Dorre , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular BUB1 as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 本发明涉及通过测量特定遗传标志物，特别是BUB1与对照相比的增加或减少来预测或监测患者对紫杉类家族分子的响应的新颖且有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白水平并将它们的水平与对照或参考标记进行比较来预测监测患者对紫杉类家族分子的反应的试剂盒。
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公开(公告)号：EP2395110A1
公开(公告)日：2011-12-14
申请号：EP11003919.5
申请日：2005-12-01
发明人： Gruenberg, Dore , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular TACC3, as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 本发明涉及与对照相比通过测量特定遗传标志物，特别是TACC3的增加或减少来预测或监测患者对紫杉类家族分子的响应的新颖且有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白水平并将它们的水平与对照或参考标记进行比较来预测监测患者对紫杉类家族分子的反应的试剂盒。
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公开(公告)号：EP2395107A1
公开(公告)日：2011-12-14
申请号：EP11003916.1
申请日：2005-12-01
发明人： Grueneberg, Dorre , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular PIM1, as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 与对照相比，本发明涉及通过测量特定遗传标志物，特别是PIM1的增加或减少来预测或监测患者对紫杉类家族分子的响应的新颖且有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白水平并将它们的水平与对照或参考标记进行比较来预测监测患者对紫杉类家族分子的反应的试剂盒。
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公开(公告)号：EP2395106A1
公开(公告)日：2011-12-14
申请号：EP11003915.3
申请日：2005-12-01
发明人： Grueneberg, Dorre , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular P21/Waf1 (CDKN1A) as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 本发明涉及通过测量特定遗传标志物，特别是与对照相比P21 / Waf1（CDKN1A）的增加或减少来预测或监测患者对紫杉类家族分子的响应的新颖且有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白水平并将它们的水平与对照或参考标记进行比较来预测监测患者对紫杉类家族分子的反应的试剂盒。
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公开(公告)号：EP2395109A1
公开(公告)日：2011-12-14
申请号：EP11003918.7
申请日：2005-12-01
发明人： Grueneberg, Dorre , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular STK11, as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 本发明涉及与对照相比，通过测量特定遗传标志物，特别是STK11的增加或减少来预测或监测患者对紫杉类家族分子的响应的新颖且有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白水平并将它们的水平与对照或参考标记进行比较来预测监测患者对紫杉类家族分子的反应的试剂盒。
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公开(公告)号：EP2395104A1
公开(公告)日：2011-12-14
申请号：EP11003913.8
申请日：2005-12-01
发明人： Grueneberg, Dorre , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular ARHGEF25, as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 本发明涉及与对照相比通过测量特定遗传标志物，特别是ARHGEF25的增加或减少来预测或监测患者对紫杉类家族分子的响应的新颖且有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白水平并将它们的水平与对照或参考标记进行比较来预测监测患者对紫杉类家族分子的反应的试剂盒。
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9.发明公开Method for measuring resistance or sensitivity to docetaxel 审中-公开Verfahren zur Messung der Resistenz oderSensitivitätgegenüber多西他赛
公开(公告)号：EP2395103A1
公开(公告)日：2011-12-14
申请号：EP11003912.0
申请日：2005-12-01
发明人： Grueneberg, Dorre , Huang, Xi , Natesan, Sridaran , August, Paul
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , G01N33/574 , G01N33/6893
摘要： The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers, in particular TTK kinase, as compared to controls. The present invention also provides kits that predict of monitor patient's response to a molecule of the taxoid family by measuring nucleic acid or protein levels of particular genetic markers and comparing their levels to controls or reference markers.
摘要翻译： 本发明涉及通过与对照相比测量特异性遗传标记物，特别是TTK激酶的增加或减少来预测或监测患者对类紫杉烷类分子的反应的新型和有用的方法。 本发明还提供了通过测量特定遗传标记的核酸或蛋白质水平并将其水平与对照或参照标记进行比较来预测监测患者对紫杉烷类分子的反应的试剂盒。
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