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1.发明公开3-SUBSTITUTED AMINO-1H-INDOLE-2-CARBOXYLIC ACID AND 3-SUBSTITUTED AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS 有权3-（氨基SUBSTITUTIERTE）-1H-吲哚-2-羧酸酯和3-（SUBSTITUTIERTE氨基） - 苯并[b]噻吩-2-羧酸酯化合物作为抑制剂的白介素-4基因表达
公开(公告)号：EP1501797A1
公开(公告)日：2005-02-02
申请号：EP03733867.0
申请日：2003-04-23
发明人： ALKAN, Sefik, S. , DINERSTEIN, Robert, J. , SUBRAMANIAM, Arun , HRIB, Nicholas, J. , JURCAK, John, G.
IPC分类号： C07D209/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D401/14 , C07D405/14 , A61K31/40 , A61P11/06 , A61P37/08 , A61P31/04
CPC分类号： C07D401/12 , A61K31/40 , A61K31/405 , C07D209/42 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： This invention discloses and claims substituted 3-amino-2-carboxylic acid indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
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2.发明授权3-(SUBSTITUTED AMINO)-1H-INDOLE-2-CARBOXYLIC ACID ESTER AND 3-(SUBSTITUTED AMINO)-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ESTER DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS 有权3-（氨基SUBSTITUTIERTE）-1H-吲哚-2-羧酸酯和3-（SUBSTITUTIERTE氨基） - 苯并[b]噻吩-2-羧酸酯化合物作为抑制剂的白介素-4基因表达
公开(公告)号：EP1501797B1
公开(公告)日：2009-08-05
申请号：EP03733867.0
申请日：2003-04-23
发明人： ALKAN, Sefik, S. , DINERSTEIN, Robert, J. , SUBRAMANIAM, Arun , HRIB, Nicholas, J. , JURCAK, John, G.
IPC分类号： C07D209/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D401/14 , C07D405/14 , A61K31/40 , A61P11/06 , A61P37/08 , A61P31/04
CPC分类号： C07D401/12 , A61K31/40 , A61K31/405 , C07D209/42 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： This invention discloses and claims substituted 3-amino-2-carboxylic acid indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
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