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公开(公告)号：EP0804466B1
公开(公告)日：1998-12-02
申请号：EP95917962.3
申请日：1995-04-26
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANITSCHKE, Lothar , JANSSEN, Bernd , KARL, Ulrich , KLING, Andreas , MÜLLER, Stefan , DE POTZOLLI, Bernd , RITTER, Kurt , THYES, Marco , ZIERKE, Thomas
IPC分类号： C07K5/10
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公开(公告)号：EP0842190A1
公开(公告)日：1998-05-20
申请号：EP96925744.0
申请日：1996-07-12
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANSSEN, Bernd , ULRICH, Karl , KLING, Andreas , MÜLLER, Stefan , RITTER, Kurt , ZIERKE, Thomas
CPC分类号： C07K7/06 , C07K5/06165 , C07K5/0808 , C07K5/101
摘要： The description relates to a process for producing pentapeptides of the formula (I) in which A and R1-R3 have the meanings given, in which the pentapeptide is constructed in steps from a prolinamide of the formula (II) in which R?1 and R2¿ have the meanings given above, and the group -NR1R2 may be hydrolytically separated from the peptide thus obtained.
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公开(公告)号：EP0758342A1
公开(公告)日：1997-02-19
申请号：EP95917963.0
申请日：1995-04-26
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANITSCHKE, Lothar , JANSSEN, Bernd , KARL, Ulrich , KLING, Andreas , MÜLLER, Stefan , DE POTZOLLI, Bernd , RITTER, Kurt , THYES, Marco , ZIERKE, Thomas
摘要： Disclosed is the compound Me2Val-Val-MeVal-Pro-Pro-NHBzl. HCl. The compound is produced from Z-Val-Val-MeVal-Pro-OR1, wherein Z and R1 have the meanings indicated in the description. The compound disclosed has anti-neoplastic properties.
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4.发明公开1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE 失效1-氨基-3-苯酚 - 丙酸衍生物多药耐药性
公开(公告)号：EP0691962A1
公开(公告)日：1996-01-17
申请号：EP94911931.0
申请日：1994-03-19
发明人： JANSSEN, Bernd , KLING, Andreas , MÜLLER, Stefan , RITTER, Kurt , SCHLECKER, Rainer , KEILHAUER, Gerhard , ROMERDAHL, Cynthia , TRAUGOTT, Ulrich
IPC分类号： C07D295 , A61K31 , A61P35 , C07D207 , C07D209 , C07D211 , C07D213 , C07D215 , C07D261 , C07D263 , C07D271 , C07D277 , C07D285 , C07D307 , C07D317 , C07D333 , C07D413 , C07D417 , C07D521 , C07F9
CPC分类号： C07D207/333 , C07D209/52 , C07D211/14 , C07D213/30 , C07D261/08 , C07D261/18 , C07D263/14 , C07D271/06 , C07D277/24 , C07D285/12 , C07D295/088 , C07D317/58 , C07D333/16 , C07D413/12 , C07D417/12 , C07F9/650958
摘要： This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula (1) (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multi-drug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.
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公开(公告)号：EP0859786A1
公开(公告)日：1998-08-26
申请号：EP96937291.0
申请日：1996-10-30
发明人： KLING, Andreas , JANSSEN, Bernd , AMBERG, Wilhelm , HAUPT, Andreas , RITTER, Kurt , BUSCHMANN, Ernst , BERNARD, Harald , MÜLLER, Stefan , ZIERKE, Thomas , BARLOZZARI, Teresa , DE ARRUDA, Monika , ROBINSON, Simon
摘要： Novel peptides of the formula A-B-D-E-F-L, wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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6.发明授权VERFAHREN ZUR HERSTELLUNG N-GESCHÜTZTER N-ALKYLIERTER AMINOSÄUREN 失效METHOD FOR PRODUCING N-保护N-烷基化氨基酸
公开(公告)号：EP0725773B1
公开(公告)日：1997-09-10
申请号：EP94930209.5
申请日：1994-10-22
发明人： KNÜHL, Klaus , KARL, Ulrich , MÜLLER, Stefan , DE POTZOLLI, Bernd
IPC分类号： C07C269/06 , C07C271/22 , C07C323/52
CPC分类号： C07C269/06
摘要： The description relates to a process for producing N-protected N-alkylated amino acids of formula (1), in which R?s and R1 to R3¿ have the meanings given in the description, in which a compound of said formula (1), wherein R3 is a hydrogen atom, is added to a solution of a base in a non-protic solvent which is then mixed with an alkylising agent.
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7.发明公开VERFAHREN ZUR HERSTELLUNG N-GESCHÜTZTER N-ALKYLIERTER AMINOSÄUREN 失效METHOD FOR PRODUCING N-保护N-烷基化氨基酸
公开(公告)号：EP0725773A1
公开(公告)日：1996-08-14
申请号：EP94930209.0
申请日：1994-10-22
发明人： KNÜHL, Klaus , KARL, Ulrich , MÜLLER, Stefan , DE POTZOLLI, Bernd
CPC分类号： C07C269/06
摘要： The description relates to a process for producing N-protected N-alkylated amino acids of formula (1), in which R and R to R have the meanings given in the description, in which a compound of said formula (1), wherein R is a hydrogen atom, is added to a solution of a base in a non-protic solvent which is then mixed with an alkylising agent.
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公开(公告)号：EP0785926B1
公开(公告)日：2001-08-22
申请号：EP95935916.7
申请日：1995-10-07
发明人： RIECHERS, Hartmut , KLINGE, Dagmar , AMBERG, Wilhelm , KLING, Andreas , MÜLLER, Stefan , BAUMANN, Ernst , RHEINHEIMER, Joachim , VOGELBACHER, Uwe, Josef , WERNET, Wolfgang , UNGER, Liliane , RASCHACK, Manfred
IPC分类号： C07D239/60 , C07D403/12 , C07D251/30 , C07D239/96 , C07D491/04 , A61K31/505
CPC分类号： C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要： Carboxylic acid derivatives have the formula (I), in which R to R6, X, Y, and Z have the meanings given in the description. Also disclosed is their preparation. These new compounds are useful for controlling diseases.
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9.发明授权1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE 失效1-氨基-3-苯氧基丙烷 - 衍生物AS与药物抗性MULTI-调节剂
公开(公告)号：EP0691962B1
公开(公告)日：2000-09-13
申请号：EP94911931.7
申请日：1994-03-19
发明人： JANSSEN, Bernd , KLING, Andreas , MÜLLER, Stefan , RITTER, Kurt , SCHLECKER, Rainer , KEILHAUER, Gerhard , ROMERDAHL, Cynthia , TRAUGOTT, Ulrich
IPC分类号： C07D261/08 , C07D261/18 , A61K31/42 , C07D295/08 , C07D413/12 , A61K31/495 , C07D333/16 , C07D285/12 , C07D213/30 , C07D263/14
CPC分类号： C07D207/333 , C07D209/52 , C07D211/14 , C07D213/30 , C07D261/08 , C07D261/18 , C07D263/14 , C07D271/06 , C07D277/24 , C07D285/12 , C07D295/088 , C07D317/58 , C07D333/16 , C07D413/12 , C07D417/12 , C07F9/650958
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10.发明授权VERFAHREN ZUR HERSTELLUNG N-Z-GESCHÜTZTER N-ALKYLIERTER AMINOSÄUREN 失效METHOD FOR PRODUCING N-Z-保护的N-烷基化的氨基酸
公开(公告)号：EP0759901B1
公开(公告)日：1999-09-01
申请号：EP95920008.0
申请日：1995-05-09
发明人： KARL, Ulrich , MÜLLER, Stefan , DE POTZOLLI, Bernd
IPC分类号： C07C227/18 , C07C229/12
CPC分类号： C07C269/06 , C07C323/59
摘要： A process for producing N-protected N-alkylated amino acids of formula (I) is described in which the components have the meaning given in the description. In the process, to a compound of formula (II) is added a solution of potassium-tert.-butanolate in a non-proteinic organic solvent and then a C1-2-alkyl halide is added.
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