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公开(公告)号：EP0991658A1
公开(公告)日：2000-04-12
申请号：EP98935531.8
申请日：1998-07-07
摘要： Compounds of the present invention include cell growth inhibitors which are peptides of Formula (I):, A - B - D - E - F - (G)r - (K)s - L and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a β-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula (I) in a pharmaceutically acceptable composition.
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公开(公告)号：EP0859786A1
公开(公告)日：1998-08-26
申请号：EP96937291.0
申请日：1996-10-30
发明人： KLING, Andreas , JANSSEN, Bernd , AMBERG, Wilhelm , HAUPT, Andreas , RITTER, Kurt , BUSCHMANN, Ernst , BERNARD, Harald , MÜLLER, Stefan , ZIERKE, Thomas , BARLOZZARI, Teresa , DE ARRUDA, Monika , ROBINSON, Simon
摘要： Novel peptides of the formula A-B-D-E-F-L, wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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3.发明公开VERFAHREN ZUR HERSTELLUNG VON $g(a)-(N,N-DIALKYL)-AMINOCARBONSÄUREAMIDEN 失效VERFAHREN ZUR HERSTELLUNG VON $ g（a） - （N，N-DIALKYL）-AMINOCARBONSÄULAMIDEN
公开(公告)号：EP0842142A1
公开(公告)日：1998-05-20
申请号：EP96925746.0
申请日：1996-07-12
发明人： BUSCHMANN, Ernst , ZIERKE, Thomas
CPC分类号： C07K7/06 , C07C231/02 , C07K1/082 , Y02P20/55
摘要： The description relates to a process for producing α-(N,N dialkyl)-amino carboxylic acid amides of formula (I) in which the constituents have the meanings given, in which the corresponding free acids are reacted with primary or secondary amines in the presence of anhydrides of an alkane phosphonic acid.
摘要翻译： 描述涉及生产式（I）的α-（N，N-二烷基） - 氨基羧酸酰胺的方法，其中组分具有给定的含义，其中相应的游离酸与伯胺或仲胺在 烷烃膦酸的酸酐的存在。
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公开(公告)号：EP1727792A1
公开(公告)日：2006-12-06
申请号：EP05716121.8
申请日：2005-03-16
发明人： ZIERKE, Thomas , ENGEL, Stefan , OTTO, Peter
IPC分类号： C07C281/04 , C07C281/14
CPC分类号： C07C281/14
摘要： The invention relates to a method for producing semicarbazone compounds of formula (I) wherein R1 and R2 independently represent hydrogen, halogen, CN, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl or C1-C4 haloalkoxy, and R3 represents C1-C4 alkoxy, C1-C4 haloalkyl or C1-C4 haloalkoxy. According to said method, a hydrazone compound of general formula (II), wherein R represents C1-C4 alkoxy, amino, C1-C4 alkylamino or di-(C1-C4-alkyl)amino, and R1 and R2 have the above-mentioned designations, is reacted with an aniline compound of general formula (III) wherein R3 has the above-mentioned designation.
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公开(公告)号：EP0915844A1
公开(公告)日：1999-05-19
申请号：EP97933675.0
申请日：1997-07-14
发明人： MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , ZIERKE, Thomas , BALKENHOHL, Friedhelm , LANGE, Udo
CPC分类号： C07D207/22
摘要： A process is disclosed for preparing 3-pyrroline-2-carboxylic acid derivatives of formula (I), in which R1 stands for H, C¿1?-C6-alkyl, benzyl, benzyl substituted at the phenyl radical, allyloxycarbonyl, C1-C6-alkyloxycarbonyl, benzyloxycarbonyl, in which the benzyl radical can be substituted by OCH3 radicals, or for C1-C4-alkylcarbonyl; or R?1¿ stands for an amino acid radical which can be alkylated or acylated at the nitrogen and is linked by the C-terminal; and R2 stands for OH, C¿1?-C4-alkyloxy, benzyloxy or an N?3R4¿ group, in which R?3 and R4¿ represent independently from each other H, C¿1?-C4-alkyl, benzyl, phenyl or pyridyl, in which the aromatic compounds in R?3 and R4¿ can be substituted by up to three identical or different substituents selected from the group composed of methyl, methoxy, hydroxy, cyano or halogen. According to this process, the sulphonic acid radical is eliminated by means of a base from a compound having the formula (II), in which R?1 and R2¿ have the above meanings and R5 stands for C¿1?-C6-alkyl, benzyl, trifluoromethyl, naphthyl or phenyl optionally substituted by radicals from the group composed of methyl, nitro and halogen.
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公开(公告)号：EP0804466B1
公开(公告)日：1998-12-02
申请号：EP95917962.3
申请日：1995-04-26
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANITSCHKE, Lothar , JANSSEN, Bernd , KARL, Ulrich , KLING, Andreas , MÜLLER, Stefan , DE POTZOLLI, Bernd , RITTER, Kurt , THYES, Marco , ZIERKE, Thomas
IPC分类号： C07K5/10
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公开(公告)号：EP0842190A1
公开(公告)日：1998-05-20
申请号：EP96925744.0
申请日：1996-07-12
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANSSEN, Bernd , ULRICH, Karl , KLING, Andreas , MÜLLER, Stefan , RITTER, Kurt , ZIERKE, Thomas
CPC分类号： C07K7/06 , C07K5/06165 , C07K5/0808 , C07K5/101
摘要： The description relates to a process for producing pentapeptides of the formula (I) in which A and R1-R3 have the meanings given, in which the pentapeptide is constructed in steps from a prolinamide of the formula (II) in which R?1 and R2¿ have the meanings given above, and the group -NR1R2 may be hydrolytically separated from the peptide thus obtained.
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公开(公告)号：EP0758342A1
公开(公告)日：1997-02-19
申请号：EP95917963.0
申请日：1995-04-26
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANITSCHKE, Lothar , JANSSEN, Bernd , KARL, Ulrich , KLING, Andreas , MÜLLER, Stefan , DE POTZOLLI, Bernd , RITTER, Kurt , THYES, Marco , ZIERKE, Thomas
摘要： Disclosed is the compound Me2Val-Val-MeVal-Pro-Pro-NHBzl. HCl. The compound is produced from Z-Val-Val-MeVal-Pro-OR1, wherein Z and R1 have the meanings indicated in the description. The compound disclosed has anti-neoplastic properties.
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公开(公告)号：EP0609259B1
公开(公告)日：1995-11-22
申请号：EP92920691.0
申请日：1992-09-26
发明人： KAST, Juergen , ZIERKE, Thomas , BRATZ, Matthias , MISSLITZ, Ulf , MEYER, Norbert , LANDES, Andreas , RADEMACHER, Wilhelm , WESTPHALEN, Karl-Otto , WALTER, Helmut
IPC分类号： C07C69/757 , C07C251/42 , C07C251/18 , A01N37/42 , C07C67/313
CPC分类号： C07C251/18 , A01N37/42 , A01N37/48 , A01N37/50 , A01N39/00 , C07C69/757 , C07C251/42 , C07C251/52 , C07C251/54 , C07C2601/16
摘要： Cyclohexenone derivates have the formula (I), in which R1 stands for alkyl, alkenyl, alkinyl, cycloalkyl, aloxyalkyl, alkylthioalkyl, possibly substituted phenyl, possibly substituted benzyl, possibly substituted 5-/6-membered heteroaryl; W stands for 0, =N-OR2 or =N-R3; R2 stands for possibly substituted alkyl, alkenyl or alkinyl residue, possibly substituted 3- to 6-membered alkyl chain or 4- to 6-membered alkenyl or alkinyl chain, a chain link in each of the chains being substituted by -0-, -S-, -S0-, -S0¿2?- or -N(R?8)-; R8¿ stands for H, alkyl, alkenyl, alkinyl, alkylcarbonyl, benzoyl; R3 stands for H, alkyl hydroxyakyl, alkoxyalkyl or alkylthioalkyl, possibly substituted phenyl, possibly substituted benzyl; X, Y stand for -OR?4 or -NR5 R6; R4¿ stands for H, alkyl, akenyl, alkinyl, alkoxyalkyl, alkylthioalkyl; R5 stands for H, alkyl, alkenyl, alkinyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl and R6 stands for H, alkyl, alkenyl, alkinyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylcarbonyl, possibly substituted benzoyl or R5-R6 form together with the shared N atom a 5-/6-membered heterocycle that may contain -O-, -S- or -N(R7)- as ring element; R7 stands for H, alkyl, alkenyl, alkinyl, alkylcarbonyl, benzoyl. Also disclosed are the agriculturally useful salts and esters of C¿1?-C10-carboxylic acids and anorganic acids of the compounds having the formula (I). These cyclohexenone derivates (I) are useful as herbicides and plant growth regulators.
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公开(公告)号：EP1506169A1
公开(公告)日：2005-02-16
申请号：EP03730050.6
申请日：2003-05-15
发明人： HAMPRECHT, Gerhard , PUHL, Michael , REINHARD, Robert , SAGASSER, Ingo , SCHMIDT, Thomas , GÖTZ, Norbert , ZIERKE, Thomas
IPC分类号： C07C307/02 , C07C303/34
CPC分类号： C07D295/26 , C07C303/34 , C07C307/00 , C07C2601/14 , C07D207/48 , C07D211/96 , C07D239/46
摘要： The invention relates to a method for the production of sulphamic acid halogenides of primary or secondary amines, comprising the following steps: i) reaction of a primary or secondary amine A1 with at least equimolar amounts of SO3 or an S03 source in the presence of at least equimolar amounts of a tertiary amine A2, respectively in relation to amine A1, and ii) reaction of the reaction mixture obtained in step i) with at least the stochiometrically required amount of phosphorus halogenide. The invention also relates to a method for the production of sulphamic acid diamides, comprising the production of sulphamic acid halogenides by carrying out steps i) and ii) and by subsequently reacting the sulphamic acid halogenides thus obtained with ammonia.The invention further relates to the use of said method in the production of herbicidal active ingredients with a sulphodiamide structure. The invention also relates to novel sulphamic acid chlorides.
摘要翻译： 本发明涉及生产伯胺或仲胺的氨基磺酰氯的方法，其包括以下步骤：i）伯或仲胺A1与至少等摩尔量的SO 3或SO 3源在 分别相对于胺A1为最少等摩尔量的叔胺A2，和ii）使步骤i）中获得的反应混合物与至少化学计量需要量的卤化磷反应。 本发明还涉及生产氨基磺酸二酰胺的方法，该方法包括通过进行步骤i）和ii）产生氨基磺酰卤，并随后使由此获得的氨基磺酸酰卤与氨反应。本发明进一步涉及 所述方法在制备具有磺基二酰胺结构的除草活性成分中的用途。 本发明还涉及新型氨基磺酰氯。
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