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公开(公告)号：EP0775167B1
公开(公告)日：1999-04-21
申请号：EP95927741.9
申请日：1995-07-28
发明人： KRONER, Matthias , SCHORNICK, Gunnar , FEINDT, Hans-Jacob , MEYER, Thomas , LUDWIG, Alfons , METZMANN, Udo
CPC分类号： C08G69/10 , C02F5/12 , C08G73/1092 , C11D3/3719
摘要： Disclosed is a method for producing polyaspartic acid by means of condensation polymerization of finely divided aspartic acid at temperatures above 150 DEG C in the presence of acid catalysts, the acid catalysts being first brought into contact with the finely divided aspartic acid in the reaction zone in which the condensation polymerization takes place.
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公开(公告)号：EP0775167A1
公开(公告)日：1997-05-28
申请号：EP95927741.0
申请日：1995-07-28
发明人： KRONER, Matthias , SCHORNICK, Gunnar , FEINDT, Hans-Jacob , MEYER, Thomas , LUDWIG, Alfons , METZMANN, Udo
CPC分类号： C08G69/10 , C02F5/12 , C08G73/1092 , C11D3/3719
摘要： Disclosed is a method for producing polyaspartic acid by means of condensation polymerization of finely divided aspartic acid at temperatures above 150 °C in the presence of acid catalysts, the acid catalysts being first brought into contact with the finely divided aspartic acid in the reaction zone in which the condensation polymerization takes place.
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3.发明授权NEUE BLUTGERINNSELAUFLÖSENDE PROTEINE UND IHRE HERSTELLUNG AUS DEM BLUTEGEL HIRUDO MEDICINALIS 失效新溶栓蛋白及其制备FROM THE水蛭。
公开(公告)号：EP0502876B1
公开(公告)日：1995-03-08
申请号：EP90917037.5
申请日：1990-11-22
发明人： MEYER, Thomas , FRIEDRICH, Thomas , KOERWER, Wolfgang , STRUBE, Karl-Hermann , BIALOJAN, Siegfried
摘要： Described is a protein which dissolves blood clots, prepared fromthe leech Hirudo Medicinalis, containing the sequences 1-13 listed in the sequence protocoland capable of splitting ε-(α-glutamyl)-lysine compounds, plus its muteins and natural variants with a comparable action.
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4.发明公开NEUE BLUTGERINNSELAUFLÖSENDE PROTEINE UND IHRE HERSTELLUNG AUS DEM BLUTEGEL HIRUDO MEDICINALIS 失效新溶栓蛋白及其制备FROM THE水蛭。
公开(公告)号：EP0502876A1
公开(公告)日：1992-09-16
申请号：EP90917037.0
申请日：1990-11-22
发明人： MEYER, Thomas , FRIEDRICH, Thomas , KOERWER, Wolfgang , STRUBE, Karl-Hermann , BIALOJAN, Siegfried
摘要： Protéine dissolvant les caillots sanguins, préparée à partir de la sangsue Hirudo medicinalis, contenant les séquences 1 à 13 indiquées dans le protocole de séquences et dissociant les liaisons epsilon-(gamma-glutamyl)-lysine, ainsi que les mutéines et les variantes naturelles de cette protéine ayant un effet comparable.
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公开(公告)号：EP0777696A1
公开(公告)日：1997-06-11
申请号：EP95929870.0
申请日：1995-08-16
发明人： KRONER, Matthias , SCHORNICK, Gunnar , STROTMANN, Uwe , SCHWENDEMANN, Volker , MEYER, Thomas , LUDWIG, Alfons
CPC分类号： C02F5/12 , C08G73/1092 , C11D3/3719
摘要： A process is disclosed for preparing polyaspartic acid salts by treating polycondensates in an aqueous medium with bases. At least 0.7 equivalents of an alkaline metal and/or alkaline earth metal base per mole of the aspartic acid, aspartic acid imide and/or amide units contained in the polycondensates are used. The bases are added during 30 minutes to 20 hours to an aqueous suspension of the polycondensates of aspartic acid heated up to 40 to 140 °C, and the reaction mixture is optionally allowed to continue to react. These alkaline metal and/or alkaline earth metal salts of polyaspartic acids obtained by treating aspartic acid polycondensates in an aqueous medium with more than 1 equivalent of an alkaline metal and/or alkaline earth metal base for reducing the molar mass of polycondensates are used as additives for washing and cleaning agents.
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公开(公告)号：EP0728209A1
公开(公告)日：1996-08-28
申请号：EP95900130.0
申请日：1994-11-10
发明人： KRÖGER, Burkhard , SEULBERGER, Harald , MEYER, Thomas , SCHMIDT, Martin , JACOB, Elard , OTTER, Rainer , SUBKOWSKI, Thomas , HILLEN, Heinz
IPC分类号： G01N33 , A61K31 , A61K35 , A61K38 , A61K39 , A61K48 , A61P9 , A61P11 , A61P13 , A61P15 , A61P25 , A61P29 , A61P31 , C07H21 , C07K14 , C12N5 , C12N9 , C12N15 , C12R1
CPC分类号： C12N9/6497 , A61K38/00 , C12Y304/24071
摘要： The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.
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公开(公告)号：EP0491755A1
公开(公告)日：1992-07-01
申请号：EP90913328.0
申请日：1990-09-12
CPC分类号： A61K38/45
摘要： Des transférases de gamme-glutamyle sont utilisées pour traiter des maladies.
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公开(公告)号：EP0777696B1
公开(公告)日：1998-02-25
申请号：EP95929870.4
申请日：1995-08-16
发明人： KRONER, Matthias , SCHORNICK, Gunnar , STROTMANN, Uwe , SCHWENDEMANN, Volker , MEYER, Thomas , LUDWIG, Alfons
CPC分类号： C02F5/12 , C08G73/1092 , C11D3/3719
摘要： A process is disclosed for preparing polyaspartic acid salts by treating polycondensates in an aqueous medium with bases. At least 0.7 equivalents of an alkaline metal and/or alkaline earth metal base per mole of the aspartic acid, aspartic acid imide and/or amide units contained in the polycondensates are used. The bases are added during 30 minutes to 20 hours to an aqueous suspension of the polycondensates of aspartic acid heated up to 40 to 140 DEG C, and the reaction mixture is optionally allowed to continue to react. These alkaline metal and/or alkaline earth metal salts of polyaspartic acids obtained by treating aspartic acid polycondensates in an aqueous medium with more than 1 equivalent of an alkaline metal and/or alkaline earth metal base for reducing the molar mass of polycondensates are used as additives for washing and cleaning agents.
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