公开(公告)号：EP0935600A1

公开(公告)日：1999-08-18

申请号：EP97913157.0

申请日：1997-10-17

申请人： BAYER AG

发明人： ANTONS, Stefan ,  GEHRING, Reinhold ,  BIELFELDT, Tim ,  BEITZKE, Bernhard

IPC分类号： C07D211 ,  C07D213 ,  C07D471

CPC分类号： C07D471/04 ,  C07D211/84 ,  C07D213/26 ,  C07D213/61

摘要： An advantageous method of producing naphthyridine compounds of formulae (Ia) to (1c) wherein R means hydrogen or C1-C4 alkyl, Ar means possibly substituted phenyl, Hal means independently fluorine, chlorine or bromine, and n stands for 1, 2 or 3, whereby a halogenated nicotinic, isonicotinic or picolinic acid is made to react with an amino acrylic acid ester to obtain a halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate which is made to react with an optionally substituted aniline to obtain a halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate which contains an amino group corresponding to the optionally substituted aniline. The second halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate is cyclized by adding an acid scavenger to a compound of formulae (Ia) to (Ic) with R = C1-C4 alkyl and, in the case of production of a compound of formulae (Ia) to (Ic) with R = H, the compound of the formulae (Ia) to (Ic) with R = C1-C4 alkyl is saponified.

公开(公告)号：EP1051388B1

公开(公告)日：2003-04-09

申请号：EP99906138.5

申请日：1999-01-16

申请人： BAYER AG

发明人： ANTONS, Stefan ,  SCHULZE TILLING, Andreas ,  WOLTERS, Erich

IPC分类号： C07C213/00 ,  C07D207/08 ,  C07D207/26

CPC分类号： C07D207/08 ,  C07B2200/07 ,  C07C213/00 ,  C07D207/26 ,  C07C215/08 ,  C07C215/10 ,  C07C215/52

摘要： The invention relates to an especially advantageous method for producing optically active amino alcohols from optically active amino acids by means of reduction in the presence of catalysts containing ruthenium, acids being added in the process.

公开(公告)号：EP1017659A1

公开(公告)日：2000-07-12

申请号：EP98951408.8

申请日：1998-09-16

申请人： BAYER AG

发明人： BRANDES, Arndt ,  LÖGERS, Michael ,  STOLTEFUSS, Jürgen ,  SCHMIDT, Gunter ,  BREMM, Klaus-Dieter ,  BISCHOFF, Hilmar ,  SCHMIDT, Delf ,  ANTONS, Stefan ,  PAULSEN, Holger ,  MÜLLER, Stephan, Nicholas ,  NAAB, Paul ,  SCHMECK, Carsten

IPC分类号： C07C35/52 ,  C07C43/192 ,  C07C49/813 ,  C07C49/83 ,  C07F7/18

CPC分类号： C07C69/76 ,  C07C35/52 ,  C07C43/192 ,  C07C49/83 ,  C07C69/757 ,  C07C69/94 ,  C07F7/1856

摘要： The invention relates to substituted tetrahydronaphthaline and analogous compounds which are produced by reducing or condensing corresponding functional substituents to substituted tetrahydronaphthaline and analogous compounds according to usual methods. In addition, functional groups are converted to the desired groups in the same manner. The inventive compounds are suited for additives in medicaments especially in medicaments for treating arteriosclerosis and dyslipidaemia.

公开(公告)号：EP1051388A1

公开(公告)日：2000-11-15

申请号：EP99906138.5

申请日：1999-01-16

申请人： BAYER AG

发明人： ANTONS, Stefan ,  SCHULZE TILLING, Andreas ,  WOLTERS, Erich

IPC分类号： C07C213/00 ,  C07D207/08 ,  C07D207/26

CPC分类号： C07D207/08 ,  C07B2200/07 ,  C07C213/00 ,  C07D207/26 ,  C07C215/08 ,  C07C215/10 ,  C07C215/52

摘要： The invention relates to an especially advantageous method for producing optically active amino alcohols from optically active amino acids by means of reduction in the presence of catalysts containing ruthenium, acids being added in the process.

公开(公告)号：EP1066232A1

公开(公告)日：2001-01-10

申请号：EP99907376.0

申请日：1999-01-16

申请人： BAYER AG

发明人： ANTONS, Stefan ,  SCHULZE TILLING, Andreas ,  WOLTERS, Erich

IPC分类号： C07C29/149

CPC分类号： C07D315/00 ,  B01J23/462 ,  B01J23/6567 ,  C07B2200/07 ,  C07C29/149 ,  C07C31/22

摘要： The invention relates to a simple method for obtaining purer optically active alcohols with a higher enantiomeric purity, in higher yields, at lower temperatures and in short reaction times by reducing the optically active carboxylic acids with hydrogen in the presence of a catalyst containing in addition to ruthenium, at least one other metal or transition metal with an atomic number between 23 and 82.