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公开(公告)号：EP0365278B1
公开(公告)日：1994-03-30
申请号：EP89310648.4
申请日：1989-10-17
申请人： BEECHAM GROUP PLC
发明人： Mannix, Christopher Joseph , Smith, Richard Anthony Godwin , Lewis, Ceris John , Harber, Julian Stanley
IPC分类号： C12N9/70
CPC分类号： C07K14/3153 , C12N9/00 , Y10S435/814 , Y10S435/815 , Y10S435/885 , Y10S514/822
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公开(公告)号：EP0365278A2
公开(公告)日：1990-04-25
申请号：EP89310648.4
申请日：1989-10-17
申请人： BEECHAM GROUP PLC
发明人： Mannix, Christopher Joseph , Smith, Richard Anthony Godwin , Lewis, Ceris John , Harber, Julian Stanley
IPC分类号： C12N9/70
CPC分类号： C07K14/3153 , C12N9/00 , Y10S435/814 , Y10S435/815 , Y10S435/885 , Y10S514/822
摘要： A process for the separation of streptokinase from contaminating proteins in a streptokinase-containing mixture, which comprises treating the mixture with a reducing agent to reduce disulphide bridges in the contaminating proteins to free thiol groups, contacting the mixture with a reagent R-X wherein R is a group capable of reacting with a free thiol group and X is a group R¹ capable of reacting with a free thiol group or is a thiol-containing matrix, and thereafter separating the resulting chemically modified contaminating proteins from the mixture to provide streptokinase in a form substantially free of contaminating proteins.
摘要翻译： 一种用于在含链激酶的混合物中将链激酶与污染蛋白分离的方法，其包括用还原剂处理混合物以减少污染蛋白质中的二硫键以游离硫醇基团，使该混合物与试剂RX接触，其中R为 能够与游离硫醇基团反应的基团，X是能够与游离巯基反应的基团R 1或含硫醇基团，然后将所得到的化学修饰的污染蛋白质与混合物分离以提供链激酶 基本上不含污染蛋白质的形式。
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公开(公告)号：EP0365278A3
公开(公告)日：1991-08-28
申请号：EP89310648.4
申请日：1989-10-17
申请人： BEECHAM GROUP PLC
发明人： Mannix, Christopher Joseph , Smith, Richard Anthony Godwin , Lewis, Ceris John , Harber, Julian Stanley
IPC分类号： C12N9/70
CPC分类号： C07K14/3153 , C12N9/00 , Y10S435/814 , Y10S435/815 , Y10S435/885 , Y10S514/822
摘要： A process for the separation of streptokinase from contaminating proteins in a streptokinase-containing mixture, which comprises treating the mixture with a reducing agent to reduce disulphide bridges in the contaminating proteins to free thiol groups, contacting the mixture with a reagent R-X wherein R is a group capable of reacting with a free thiol group and X is a group R¹ capable of reacting with a free thiol group or is a thiol-containing matrix, and thereafter separating the resulting chemically modified contaminating proteins from the mixture to provide streptokinase in a form substantially free of contaminating proteins.
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4.发明公开
公开(公告)号：EP0184363A2
公开(公告)日：1986-06-11
申请号：EP85308534.8
申请日：1985-11-25
申请人： BEECHAM GROUP PLC
CPC分类号： C12N9/6435 , A61K38/00 , C12N9/6459 , C12Y304/21007 , C12Y304/21069
摘要： A conjugate comprising a plurality of fibrinolytic enzymes linked together through the active centres thereof by means of a removable blocking group.
摘要翻译： 包含多个纤维蛋白溶解酶的缀合物，其通过其可移除的封闭基团通过其活性中心连接在一起。
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5.发明公开Enzyme-protein conjugate, process for its preparation and pharmaceutical use thereof 失效Enzym-Protein-Konjugat，Verfahren zu seiner Herstellung und seine pharmazeutische Verwendung。
公开(公告)号：EP0155388A2
公开(公告)日：1985-09-25
申请号：EP84115346.3
申请日：1984-12-13
申请人： BEECHAM GROUP PLC
IPC分类号： A61K37/54 , A61K37/547 , C12N9/50 , C12N9/68 , C12N9/72 , C12N11/06 , C12N11/02 , C07D213/70
CPC分类号： C07D213/71 , C12N11/06
摘要： A derivative of a fibrinolytic enzyme in which the catalytic site on the enzyme which is responsible for fibrinolytic activity is blocked by human protein attached thereto by way of a reversible linking group.
摘要翻译： 纤维蛋白溶解酶的衍生物，其中负责纤维蛋白溶解活性的酶上的催化位点被通过可逆连接基团连接到其上的人蛋白质阻断。
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6.发明授权Enzyme-protein conjugate, process for its preparation and pharmaceutical use thereof 失效酶与蛋白质结合体，其制备方法及药物用途
公开(公告)号：EP0155388B1
公开(公告)日：1989-03-29
申请号：EP84115346.3
申请日：1984-12-13
申请人： BEECHAM GROUP PLC
IPC分类号： A61K37/54 , A61K37/547 , C12N9/50 , C12N9/68 , C12N9/72 , C12N11/06 , C12N11/02 , C07D213/70
CPC分类号： C07D213/71 , C12N11/06
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7.发明公开Enzyme-protein conjugate, process for its preparation and pharmaceutical composition 失效酶 - 蛋白质结合体，其制备方法和药物组合物
公开(公告)号：EP0152736A3
公开(公告)日：1986-12-10
申请号：EP85100084
申请日：1985-01-04
申请人： BEECHAM GROUP PLC
CPC分类号： C12N9/6456 , A61K38/00 , A61K47/6815 , C12N11/02 , Y10S530/812
摘要： A fibrinolytically active protein conjugate comprising at least one optionally blocked fibrinolytic enzyme linked by way of a site other than the catalytic site responsible for fibrinolytic activity to at least one human protein. Processes from making the conjugates and pharmaceutical compositions containing them are also described.
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8.发明授权Enzyme derivatives for use in the treatment of venous thrombosis, compositions containing them and their preparation 失效用于治疗静脉血栓形成的酶衍生物，含有它们的组合物及其制备
公开(公告)号：EP0009879B1
公开(公告)日：1983-10-12
申请号：EP79301773.2
申请日：1979-08-30
申请人： BEECHAM GROUP PLC
CPC分类号： C12N9/6435 , A61K38/00 , C07D307/54 , C07K14/3153 , C12N9/6462 , C12N9/96 , C12Y304/21007 , C12Y304/21073
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9.发明公开Enzyme derivatives for use in the treatment of venous thrombosis, compositions containing them and their preparation 失效用于静脉血栓形成和包含它们的药物组合物的治疗用途酶衍生物。
公开(公告)号：EP0009879A1
公开(公告)日：1980-04-16
申请号：EP79301773.2
申请日：1979-08-30
申请人： BEECHAM GROUP PLC
CPC分类号： C12N9/6435 , A61K38/00 , C07D307/54 , C07K14/3153 , C12N9/6462 , C12N9/96 , C12Y304/21007 , C12Y304/21073
摘要： A pharmaceutical composition which comprises a pharmaceutically acceptable carrier together with an in vivo fibrinolytic enzyme as defined herein wherein the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis at a rate such that the pseudo-first order rate constant for hydrolysis is in the range 10- 6 sec -1 to 10 -3 sec -1 in isotonic aqueous media at pH 7.4 at 37°C; is useful in the treatment of venous thrombosis.
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公开(公告)号：EP0184363A3
公开(公告)日：1987-12-23
申请号：EP85308534
申请日：1985-11-25
申请人： BEECHAM GROUP PLC
CPC分类号： C12N9/6435 , A61K38/00 , C12N9/6459 , C12Y304/21007 , C12Y304/21069
摘要： A conjugate comprising a plurality of fibrinolytic enzymes linked together through the active centres thereof by means of a removable blocking group.
摘要翻译： 包含多个纤维蛋白溶解酶的缀合物，其通过其可移除的封闭基团通过其活性中心连接在一起。
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