公开(公告)号：EP0840648B1

公开(公告)日：2001-09-05

申请号：EP97925131.1

申请日：1997-05-23

申请人： BIO MERIEUX

发明人： ELAISSARI, Abdelhamid ,  PICHOT, Christian ,  MANDRAND, Bernard ,  SAUZEDDE, Florence

IPC分类号： B03C1/01 ,  H01F1/37 ,  H01F1/44 ,  G01N33/543

CPC分类号： H01F1/37 ,  B03C1/01 ,  G01N33/5375 ,  G01N33/5434 ,  G01N2446/10 ,  G01N2446/40 ,  G01N2446/84 ,  G01N2446/86 ,  H01F1/44 ,  Y10S436/806 ,  Y10S436/824 ,  Y10T428/2982 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T436/24

摘要： The invention discloses superparamagnetic monodispersed particles, their method of preparation and their uses. These particles comprise: a core of a first polymer, an internal layer of a second polymer coating the core, and in which is distributed a magnetic material, and an external layer of a third polymer coating the magnetic layer, and capable of interacting with at least one biological molecule, at least the second polymer being heat sensitive and having a predetermined lower critical solubility temperature (LCST) of 15 to 65 DEG C.

公开(公告)号：EP0840648A1

公开(公告)日：1998-05-13

申请号：EP97925131.0

申请日：1997-05-23

申请人： BIO MERIEUX

发明人： ELAISSARI, Abdelhamid ,  PICHOT, Christian ,  MANDRAND, Bernard ,  SAUZEDDE, Florence

IPC分类号： B03C1 ,  G01N33 ,  H01F1

CPC分类号： H01F1/37 ,  B03C1/01 ,  G01N33/5375 ,  G01N33/5434 ,  G01N2446/10 ,  G01N2446/40 ,  G01N2446/84 ,  G01N2446/86 ,  H01F1/44 ,  Y10S436/806 ,  Y10S436/824 ,  Y10T428/2982 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T436/24

摘要： The invention discloses superparamagnetic monodispersed particles, their method of preparation and their uses. These particles comprise: a core of a first polymer, an internal layer of a second polymer coating the core, and in which is distributed a magnetic material, and an external layer of a third polymer coating the magnetic layer, and capable of interacting with at least one biological molecule, at least the second polymer being heat sensitive and having a predetermined lower critical solubility temperature (LCST) of 15 to 65 °C.