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1.发明授权PROCEDE DE DETECTION DE L'EXPRESSION D'UNE PROTEINE D'ENVELOPPE D'UN RETROVIRUS ENDOGENE HUMAIN ET UTILISATIONS D'UN GENE CODANT POUR CETTE PROTEINE 有权程序对认证表达的包膜蛋白的内源性逆转录病毒人类基因启动子区使用了这样的编码蛋白
公开(公告)号：EP1212359B1
公开(公告)日：2011-11-02
申请号：EP00960783.9
申请日：2000-09-01
发明人： MALLET, François , COSSET, François-Loic , BLOND, Jean-Luc , LAVILLETTE, Dimitri , BOUTON, Olivier , RUGGIERI, Alessia
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C12N2740/10022
摘要： The invention concerns a method for detecting the expression of an envelope protein or polypeptide of a human endogenous retrovirus, characterised in that the protein or polypeptide has a polypeptide sequence comprising the sequence SEQ ID NO: 1 or a fragment of SEQ ID NO: 1 or a sequence having, for every sequence of 20 amino acids, at least 90 % identity with the SEQ ID NO: 1 or with a fragment of SEQ ID NO: 1, and the method consists in detecting the fusogenic power of said protein or said fragment in the cells of a cell tissue or cell culture, by demonstrating the formation of syncytia. A gene or a nucleic acid or a fragment thereof is used for preparing a therapeutic or prophylactic composition, in particular for treating cancers and for preventing deficiency in placental development.
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2.发明公开PROCEDE DE DETECTION DE L'EXPRESSION D'UNE PROTEINE D'ENVELOPPE D'UN RETROVIRUS ENDOGENE HUMAIN ET UTILISATIONS D'UN GENE CODANT POUR CETTE PROTEINE 有权程序对认证表达的包膜蛋白的内源性逆转录病毒人类基因启动子区使用了这样的编码蛋白
公开(公告)号：EP1212359A1
公开(公告)日：2002-06-12
申请号：EP00960783.9
申请日：2000-09-01
发明人： MALLET, François , COSSET, François-Loic , BLOND, Jean-Luc , LAVILLETTE, Dimitri , BOUTON, Olivier , RUGGIERI, Alessia
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C12N2740/10022
摘要： The invention concerns a method for detecting the expression of an envelope protein or polypeptide of a human endogenous retrovirus, characterised in that the protein or polypeptide has a polypeptide sequence comprising the sequence SEQ ID NO: 1 or a fragment of SEQ ID NO: 1 or a sequence having, for every sequence of 20 amino acids, at least 90 % identity with the SEQ ID NO: 1 or with a fragment of SEQ ID NO: 1, and the method consists in detecting the fusogenic power of said protein or said fragment in the cells of a cell tissue or cell culture, by demonstrating the formation of syncytia. A gene or a nucleic acid or a fragment thereof is used for preparing a therapeutic or prophylactic composition, in particular for treating cancers and for preventing deficiency in placental development.
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3.发明公开SEQUENCES RETROVIRAUX ENDOGENES, ASSOCIEES A DES MALADIES AUTO-IMMUNES ET/OU A DES PERTURBATIONS DE LA GROSSESSE 失效内源性逆转录病毒序列进行自身免疫性疾病和怀孕相关问题
公开(公告)号：EP1000158A1
公开(公告)日：2000-05-17
申请号：EP98935106.9
申请日：1998-07-06
申请人： BIO MERIEUX
发明人： BESEME, Frédéric , BLOND, Jean-Luc , BOUTON, Olivier , MANDRAND, Bernard , MALLET, François , PERRON, Herve
IPC分类号： C12N15/48 , C07K14/15 , C12Q1/68 , C07K16/10 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/10022 , G01N33/564
摘要： The invention concerns a genomic retroviral nucleic material, in isolated or purified state, at least partially functional or non-functional, whereof the genome comprises a reference nucleotide sequence selected from the group including sequences SEQ ID Nos: 1 to 15, their complementary sequences, and their equivalent sequences, in particular the nucleotide sequences having, for every series of 100 contiguous monomers, at least 70 % and preferably at least 90 % homology with said sequences SEQ ID Nos: 1 to 15. The invention also concerns the application of said material.
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4.发明授权SEQUENCES RETROVIRAUX ENDOGENES, ASSOCIEES A DES MALADIES AUTO-IMMUNES ET/OU A DES PERTURBATIONS DE LA GROSSESSE 失效内源性逆转录病毒序列进行自身免疫性疾病和怀孕相关问题
公开(公告)号：EP1000158B1
公开(公告)日：2006-11-22
申请号：EP98935106.9
申请日：1998-07-06
申请人： BIO MERIEUX
发明人： BESEME, Frédéric , BLOND, Jean-Luc , BOUTON, Olivier , MANDRAND, Bernard , MALLET, François , PERRON, Herve
IPC分类号： C12N15/48 , C07K14/15 , C12Q1/68 , C07K16/10 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/10022 , G01N33/564
摘要： The invention concerns a genomic retroviral nucleic material, in isolated or purified state, at least partially functional or non-functional, whereof the genome comprises a reference nucleotide sequence selected from the group including sequences SEQ ID Nos: 1 to 15, their complementary sequences, and their equivalent sequences, in particular the nucleotide sequences having, for every series of 100 contiguous monomers, at least 70 % and preferably at least 90 % homology with said sequences SEQ ID Nos: 1 to 15. The invention also concerns the application of said material.
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