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1.发明授权PEPTIDES AND PEPTIDE ANALOGUES DESIGNED FROM HFE PROTEIN AND THEIR USES IN THE TREATMENT OF IRON OVERLOAD DISEASES 有权肽和肽类似物，衍生于HFE蛋白质和铁造成的收入它们在疾病治疗
公开(公告)号：EP1140131B1
公开(公告)日：2009-06-17
申请号：EP99965204.3
申请日：1999-12-10
发明人： FEDER, John, N. , SCHATZMAN, Randall, C. , BJORKMAN, Pamela, J. , BENNETT, Melanie , LEBRON, Jose
CPC分类号： C07K14/70539 , A61K38/00
摘要： The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.
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2.发明授权METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF IRON OVERLOAD DISEASES AND IRON DEFICIENCY DISEASES 失效方法和组合物与铁的收入或缺铁性相关疾病的诊断和治疗。
公开(公告)号：EP0988316B1
公开(公告)日：2006-08-09
申请号：EP98930243.5
申请日：1998-06-12
CPC分类号： C07K14/70539 , A61K38/00
摘要： Methods and compositions are provided for the diagnosis and treatment of iron overload diseases and iron deficiency diseases.
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3.发明授权POLYMORPHISMS AND NEW GENES IN THE REGION OF THE HUMAN HEMOCHROMATOSIS GENE 失效多态性与新基因在人类HEMOCHROMATOSISGENS区域
公开(公告)号：EP0960114B1
公开(公告)日：2007-09-19
申请号：EP97910741.4
申请日：1997-09-30
发明人： FEDER, John, N. , KRONMAL, Gregory, S. , LAUER, Peter, M. , RUDDY, David, A. , THOMAS, Winston, J. , TSUCHIHASHI, Zenta , WOLFF, Roger, K.
CPC分类号： C07K14/70503 , C07K14/70539 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Polymorphic sites in the region surrounding the HFE gene are provided. These polymorphisms are useful as surrogate markers in diagnostic assays for hemochromatosis. Additionally, a fine structure map of the 1 megabase region surrounding the HFE gene is provided, along with 235 kb of DNA sequence and 8 loci corresponding to candidate genes within the 1 megabase region, and in the purification of related proteins.
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公开(公告)号：EP0954602B1
公开(公告)日：2005-06-15
申请号：EP97918642.6
申请日：1997-04-04
发明人： THOMAS, Winston, J. , DRAYNA, Dennis, T. , FEDER, John, N. , GNIRKE, Andreas , RUDDY, David , TSUCHIHASHI, Zenta , WOLFF, Roger, K.
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04 , A61K38/00 , A61K39/00 , A61K39/395 , C07K14/47 , A61K38/17 , C07K14/705 , C12N15/85 , C12N15/10 , C07K16/28
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/70539 , C12Q1/6883
摘要： The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also relates to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
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5.发明公开METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF IRON OVERLOAD DISEASES AND IRON DEFICIENCY DISEASES 失效方法和组合物与铁的收入或缺铁性相关疾病的诊断和治疗。
公开(公告)号：EP0988316A1
公开(公告)日：2000-03-29
申请号：EP98930243.5
申请日：1998-06-12
CPC分类号： C07K14/70539 , A61K38/00
摘要： Methods and compositions are provided for the diagnosis and treatment of iron overload diseases and iron deficiency diseases.
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6.发明公开PEPTIDES AND PEPTIDE ANALOGUES DESIGNED FROM HFE PROTEIN AND THEIR USES IN THE TREATMENT OF IRON OVERLOAD DISEASES 有权肽和肽类似物，衍生于HFE蛋白质和铁造成的收入它们在疾病治疗
公开(公告)号：EP1140131A2
公开(公告)日：2001-10-10
申请号：EP99965204.3
申请日：1999-12-10
发明人： FEDER, John, N. , SCHATZMAN, Randall, C. , BJORKMAN, Pamela, J. , BENNETT, Melanie , LEBRON, Jose
CPC分类号： C07K14/70539 , A61K38/00
摘要： The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.
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