公开(公告)号：EP0533744A1

公开(公告)日：1993-03-31

申请号：EP91910808.0

申请日：1991-06-10

申请人： BIOCHEM PHARMA INC. ,  BELLEAU, Bernard, legally represented by BELLEAU Pierrette

发明人： ATTARDO, Giorgio ,  XU, Yao, Chang ,  LAVALLEE, Jean-François ,  REJ, Rabindra, N. ,  BELLEAU, Bernard

IPC分类号： A61K31 ,  A61K38 ,  A61K39 ,  A61P31 ,  A61P35 ,  C07C43 ,  C07C69 ,  C07C239 ,  C07C323 ,  C07D217 ,  C07D221 ,  C07D311 ,  C07D319 ,  C07D327 ,  C07D333 ,  C07D335 ,  C07D407 ,  C07H15 ,  C07H17

CPC分类号： C07D335/06 ,  C07D311/76 ,  C07D311/78 ,  C07D319/06 ,  C07D327/06 ,  C07D333/72 ,  C07D335/04 ,  C07D407/04 ,  C07H15/244 ,  C07H15/252 ,  C07H17/00 ,  C07H17/08

摘要： On décrit des dérivés hétérocycliques d'anthracycline et d'anthracyclinone utiles au traitement des cancers et des tumeurs par exemple le cancer du sein, la leucémie, le cancer du poumon, le cancer du côlon, le cancer ovarien, le cancer du rein, le cancer du système nerveux central et le mélanome. On décrit également des compositions pharmaceutiques et des procédés de préparation des composés.

公开(公告)号：EP0560794B1

公开(公告)日：1996-09-18

申请号：EP91919496.9

申请日：1991-11-12

申请人： BIOCHEM PHARMA INC.

发明人： BELLEAU, Bernard ,  BRASILI, Livio ,  NGUYEN-BA, Nghe ,  LAVAL, Chan, Chun, Kong

IPC分类号： C07D411/04 ,  C07D473/02 ,  A61K31/505 ,  C07F7/18

CPC分类号： C07D473/00 ,  C07D409/04 ,  C07D411/04 ,  C07F7/1856 ,  C07H21/00

摘要： This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes of formula (1) wherein X is S, S=O, or SO2; Y is O, S, S=O, or SO2; R1 is hydrogen, trisubstituted silyl, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted C1-16 acyl; and R2 is a purine or pyrimidine base or an analogue or derivative thereof; and pharmaceutically acceptable derivatives thereof. This invention also relates to processes for preparing these compounds, intermediates useful in their preparation, to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents.

公开(公告)号：EP0485458B1

公开(公告)日：1997-10-22

申请号：EP90911857.2

申请日：1990-08-03

申请人： BIOCHEM PHARMA INC.

发明人： BRILLON, Denis ,  SAUVE, Gilles ,  ZACHARIE, Boulos ,  BELLEAU, Bernard

IPC分类号： C07D235/26 ,  C07C327/40 ,  C07C233/43 ,  C07K5/08 ,  C07K5/10 ,  C07K5/06

CPC分类号： C07D403/12 ,  A61K38/00 ,  C07D235/26 ,  C07K5/02 ,  C07K5/0815 ,  C07K5/0819 ,  C07K5/1013 ,  C07K14/66

摘要： Thioacylating reagents are provided for the introduction of thioamide bonds into growing peptides represented by structure (I), where the substituents are disclosed herein. Intermediate precursors for preparing these thioacylating reagents are also provided. A process for preparing the thioacylating reagents and the intermediate precursors is further provided. Thiopeptides, and salts thereof, that exhibit pharmacological utility are provided and are represented by formula (II), wherein R?1, R3, R4¿, X and n are as defined herein. Methods for preparing these thiopeptides from solution and solid phase syntheses, utilizing the thioacylating reagents disclosed herein, are also provided.

公开(公告)号：EP0565549B1

公开(公告)日：1995-04-05

申请号：EP92901354.8

申请日：1992-01-03

申请人： BIOCHEM PHARMA INC.

发明人： NGUYEN-BA, Nghe ,  BELLEAU, Bernard

IPC分类号： A61K31/505

CPC分类号： A61K31/70 ,  A61K31/505

摘要： Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed.