公开(公告)号：EP4406961A1

公开(公告)日：2024-07-31

申请号：EP22872987.7

申请日：2022-09-22

申请人： AGC INC. ,  The University of Tokyo

发明人： KASHIWAGI, Kimiaki ,  OKAZOE, Takashi ,  AIKAWA, Kohsuke ,  SANDO, Shinsuke ,  MORIMOTO, Jumpei ,  KADOTA, Koji ,  KOHATA, Ai

IPC分类号： C07K5/02 ,  C07K5/08

CPC分类号： Y02P20/55 ,  C07K5/02 ,  C07K5/08

摘要： The present invention provides a peptide having a fluoroalkyl group in the side chain. The present invention provides a peptide in which 2 or more amino acids are peptide-bonded in which at least one side chain of an amino acid residue constituting the peptide is represented by the following General Formula (1) [in the formula, Z1 is a divalent, trivalent, or tetravalent linking group other than an alkylene group; Rf is a C1-30 alkyl group substituted with at least two fluorine atoms, -SF5, or -SF4-CR101R102-CR103R104Cl (R101, R102, R103, and R104 are each independently a hydrogen atom, a fluorine atom, or a chlorine atom, and two or more of R101, R102, R103, and R104 are fluorine atoms); n3 is 1, 2, of 3, and the black circle indicates a bonding site].

公开(公告)号：EP3388444A1

公开(公告)日：2018-10-17

申请号：EP17165651.5

申请日：2017-04-10

申请人： F. Hoffmann-La Roche AG

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07K5/02 ,  A61K38/00 ,  A61P31/04

CPC分类号： C07K5/02

摘要： The present invention relates to compounds of formula (I)

wherein X 1 to X 8 and R 1 to R 8 are as described herein, as well as pharmaceutically acceptable salts thereof for the use in the treatment or prevention of infections and resulting diseases caused by Pseudomonas aeruginosa.

公开(公告)号：EP3129362A1

公开(公告)日：2017-02-15

申请号：EP15777523.0

申请日：2015-04-10

申请人： Medimmune, LLC

发明人： GINGIPALLI, Lakshmaiah ,  TOADER, Dorin ,  WANG, Fengjiang

IPC分类号： C07D277/30 ,  A61K31/426 ,  A61K31/427

CPC分类号： A61K47/48569 ,  A61K38/00 ,  A61K47/6803 ,  C07D417/12 ,  C07D417/14 ,  C07K5/02 ,  C07K5/021 ,  C07K5/0212 ,  C07K5/06034 ,  C07K16/30

摘要： Novel tubulysin derivatives which may be useful as cytotoxic agents to provide therapeutic benefits in the treatment of various types of cancers, alone or as drug conjugates with antibodies are provided. The tubulysin derivatives consist of a tetrapeptide scaffold comprising methyl and ethyl substituted piperidines. The tubulysin conjugates further comprise monoclonal antibody via succinimide linkers.

摘要翻译： 本发明提供了可用作细胞毒剂的新的微管蛋白抑制剂衍生物，以单独作为药物偶联物或与其他化学疗法联合治疗各种类型的癌症提供治疗益处。

公开(公告)号：EP2709650B1

公开(公告)日：2017-02-08

申请号：EP12768043.7

申请日：2012-04-02

申请人： Washington State University

发明人： HARDING, Joseph, W. ,  WRIGHT, John, W. ,  BENOIST, Caroline, C. ,  KAWAS, Leen, H. ,  WAYMAN, Gary, A.

IPC分类号： A61K38/18 ,  A61K38/17 ,  A61P25/28 ,  A61P3/10 ,  A61P35/00 ,  C07K5/02 ,  A61K38/00 ,  C07K5/083 ,  A61K38/07 ,  A61K38/06 ,  A61K45/06

CPC分类号： A61K38/06 ,  A61K38/00 ,  A61K38/07 ,  A61K45/06 ,  C07K5/02 ,  C07K5/021 ,  C07K5/0808

公开(公告)号：EP2714685B1

公开(公告)日：2016-10-19

申请号：EP12793459.4

申请日：2012-05-24

申请人： Ambrx, Inc.

发明人： MIAO, Zhenwei ,  ATKINSON, Kyle, C. ,  BIROC, Sandra ,  BUSS, Timothy ,  COOK, Melissa ,  KRAYNOV, Vadim ,  MARSDEN, Robin ,  PINKSTAFF, Jason ,  SKIDMORE, Lillian ,  SUN, Ying ,  SZYDLIK, Agnieszka ,  LOPEZ DE VALENTA, Delia Ianina

IPC分类号： C07D417/12 ,  C07D401/12 ,  C07D207/325 ,  A61K31/427 ,  A61P35/00 ,  C07K5/02 ,  A61K39/395 ,  A61K47/48 ,  A61K31/337 ,  C07K5/06 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K5/06 ,  A61K31/337 ,  A61K31/427 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6855 ,  A61K2039/505 ,  C07D207/325 ,  C07D401/12 ,  C07D417/12 ,  C07K5/02 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/76 ,  A61K2300/00

摘要： Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.

公开(公告)号：EP2201025B1

公开(公告)日：2016-04-20

申请号：EP08836952.5

申请日：2008-10-13

申请人： Kode Biotech Limited

发明人： BOVIN, Nicolai ,  HENRY, Stephen Micheal ,  RODIONOV, Igor ,  WEINBERG, Cristina-Simona ,  TUZIKOV, Alexander Borisovich

IPC分类号： A61K47/48 ,  C07F9/6561 ,  G01N33/80 ,  C07K7/06 ,  C07K7/08

CPC分类号： C07K7/02 ,  A61K47/544 ,  A61K47/65 ,  C07F9/106 ,  C07F9/5721 ,  C07F9/6561 ,  C07K5/02 ,  C07K7/06 ,  C07K7/08 ,  G01N33/80

摘要： The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.

摘要翻译： 本发明涉及用于实现在细胞和多细胞结构表面表达的功能部分的定性和定量变化的方法，以及用于这些方法的功能性脂质构建体。 特别地，本发明涉及功能性脂质构建体及其在诊断和治疗应用中的应用，包括血清学诊断，其中功能部分是碳水化合物，肽，化学反应性基团，共轭体或荧光团。

公开(公告)号：EP2448923B1

公开(公告)日：2015-11-25

申请号：EP10794587.5

申请日：2010-06-25

申请人： Tetralogic Pharmaceuticals Corp.

发明人： CONDON, Stephen, M. ,  DENG, Yijun ,  LAPORTE, Matthew, G. ,  RIPPIN, Susan, R.

IPC分类号： C07K5/06 ,  A61P35/00 ,  C07D403/06

CPC分类号： A61K38/05 ,  A61K31/404 ,  A61K31/555 ,  A61K38/00 ,  A61K38/07 ,  A61K45/06 ,  A61N5/062 ,  A61N5/10 ,  C07D403/06 ,  C07D403/14 ,  C07K5/02 ,  C07K5/06 ,  C07K5/06026 ,  C12N5/0693 ,  C12N2500/46 ,  Y02P20/55

摘要： A SMAC mimetic and pharmaceutical compositions thereof and methods of use.

公开(公告)号：EP2934602A1

公开(公告)日：2015-10-28

申请号：EP13815929.8

申请日：2013-12-18

申请人： Genentech, Inc.

发明人： BOSWELL, Charles Andrew ,  KHAWLI, Leslie ,  MARIK, Jan ,  WILLIAMS, Simon

IPC分类号： A61K51/04 ,  A61K51/08 ,  A61K51/10

CPC分类号： A61K49/16 ,  A61K51/0482 ,  A61K51/08 ,  A61K51/088 ,  A61K51/103 ,  A61K51/1051 ,  A61K51/1093 ,  C07B59/002 ,  C07D207/404 ,  C07D207/452 ,  C07K1/13 ,  C07K5/02 ,  C07K16/28

摘要： Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.

摘要翻译： 提供了用放射性卤素标记试剂标记蛋白质的方法和组合物。 放射性卤素标记的蛋白质可用作成像研究，作为治疗剂和诊断测试。 [125I] HIP-DOTA标签试剂6通过有效和方便的方法制备。

公开(公告)号：EP2736523A4

公开(公告)日：2015-10-28

申请号：EP12818199

申请日：2012-07-27

申请人： UNIV QUEENSLAND

发明人： FAIRLIE DAVID PAUL ,  LIU LIGONG ,  YAU MEI-KWAN ,  SUEN JACKY YUNG ,  REID ROBERT ,  LOHMAN RINK-JAN ,  IYER ABISHEK VENKATASUBRAMANIAN ,  LIM JUNXIAN ,  BROWN LINDSAY CHARLES

IPC分类号： A61K38/05 ,  A61K38/06 ,  A61P3/04 ,  A61P5/00 ,  A61P9/00 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078 ,  C07K5/083

CPC分类号： C07K5/08 ,  A61K38/05 ,  C07K5/02 ,  C07K5/06 ,  C07K5/06078

摘要： The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.

公开(公告)号：EP2709650A4

公开(公告)日：2015-04-22

申请号：EP12768043

申请日：2012-04-02

申请人： UNIV WASHINGTON STATE RES FDN

发明人： HARDING JOSEPH W ,  WRIGHT JOHN W ,  BENOIST CAROLINE C ,  KAWAS LEEN H ,  WAYMAN GARY A

IPC分类号： A61K38/18 ,  A61K38/00 ,  A61K38/17 ,  A61P3/10 ,  A61P25/28 ,  A61P35/00 ,  C07K5/02 ,  C07K5/083

CPC分类号： A61K38/06 ,  A61K38/00 ,  A61K38/07 ,  A61K45/06 ,  C07K5/02 ,  C07K5/021 ,  C07K5/0808