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1.发明授权STEREOSELECTIVE SYNTHESIS OF NUCLEOSIDE ANALOGUES USING BICYCLIC INTERMEDIATE 失效模拟NUKLEOZIDEN立体选择性合成使用双环中间体
公开(公告)号：EP0654031B1
公开(公告)日：1999-12-29
申请号：EP94918252.1
申请日：1994-06-07
申请人： BIOCHEM PHARMA INC.
发明人： MANSOUR, Tarek, S. , EVANS, Colleen, A. , JIN, Haolun , SIDDIQUI, Arshad, M. , TSE, Allan, H., L.
IPC分类号： C07D411/04 , C07D473/00 , C07D497/08
CPC分类号： C07D473/00 , C07D411/04 , C07D497/08
摘要： The present invention relates to a process for producing predominantly pure cis nucleoside analogues using a novel bicyclic intermediate of formula (III), wherein X is S, or O; Y is S, CH2, O or CH(R); wherein R is azido or halogen; and Z is S or O.
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2.发明公开STEREOSELECTIVE SYNTHESIS OF NUCLEOSIDE ANALOGUES USING BICYCLIC INTERMEDIATE 失效模拟NUKLEOZIDEN立体选择性合成使用中间双环。
公开(公告)号：EP0654031A1
公开(公告)日：1995-05-24
申请号：EP94918252.0
申请日：1994-06-07
申请人： BIOCHEM PHARMA INC.
发明人： MANSOUR, Tarek, S. , EVANS, Colleen, A. , JIN, Haolun , SIDDIQUI, Arshad, M. , TSE, Allan, H., L.
CPC分类号： C07D473/00 , C07D411/04 , C07D497/08
摘要： The present invention relates to a process for producing predominantly pure cis nucleoside analogues using a novel bicyclic intermediate of formula (III), wherein X is S, or O; Y is S, CH2, O or CH(R); wherein R is azido or halogen; and Z is S or O.
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3.发明授权PROCESS FOR PREPARING SUBSTITUTED 1,3-OXATHIOLANES WITH ANTIVIRAL PROPERTIES 失效PROCESS FOR抗病毒的制备取代的1,3-氧硫杂环戊烷
公开(公告)号：EP0674634B1
公开(公告)日：2003-04-16
申请号：EP93900063.4
申请日：1992-12-21
申请人： BIOCHEM PHARMA INC
发明人： MANSOUR, Tarek , TSE, Allan H.L. , EVANS, Colleen, A. , JIN, Haolun , ZACHARIE, Boulos , NGUYEN-BA, Nghe , BELLEAU, Bernard +di
IPC分类号： C07D411/04 , C07D473/00 , C07D473/40 , C07D327/04
CPC分类号： C07D327/04 , C07D405/04 , C07D411/04 , C07D411/14 , C07D473/00 , C07D473/40
摘要： Disclosed are processes for preparing compounds of formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S = O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
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4.发明公开PROCESS FOR PREPARING SUBSTITUTED 1,3-OXATHIOLANES WITH ANTIVIRAL PROPERTIES 失效PROCESS FOR抗病毒的制备取代的1,3-氧硫杂环戊烷。
公开(公告)号：EP0674634A1
公开(公告)日：1995-10-04
申请号：EP93900063.0
申请日：1992-12-21
申请人： BIOCHEM PHARMA INC.
发明人： MANSOUR, Tarek , TSE, Allan H.L. , EVANS, Colleen, A. , JIN, Haolun , ZACHARIE, Boulos , NGUYEN-BA, Nghe , BELLEAU, Bernard +di
CPC分类号： C07D327/04 , C07D405/04 , C07D411/04 , C07D411/14 , C07D473/00 , C07D473/40
摘要： Disclosed are processes for preparing compounds of formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S = O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
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