公开(公告)号：EP4166539B1

公开(公告)日：2024-10-09

申请号：EP22198597.1

申请日：2021-08-06

IPC分类号： C07D207/267 ,  C07D403/12 ,  C07D403/14 ,  A61P31/14 ,  C07D401/12 ,  C07D497/04 ,  A61K31/4015 ,  A61K31/4025

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D207/267 ,  C07D497/04 ,  C07D403/14 ,  A61P31/14

公开(公告)号：EP4396190A1

公开(公告)日：2024-07-10

申请号：EP22769944.4

申请日：2022-08-29

申请人： Saltigo GmbH

发明人： LANGER, Reinhard

IPC分类号： C07D497/04 ,  A01N47/00 ,  C10G70/04 ,  B01D3/00

CPC分类号： C07D497/04 ,  B01D1/225 ,  B01D3/148 ,  B01D3/10

公开(公告)号：EP4389745A1

公开(公告)日：2024-06-26

申请号：EP22815335.9

申请日：2022-06-02

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. ,  Shanghai Senhui Medicine Co., Ltd. ,  Retrolead (Shanghai) Biopharma Co., Ltd.

发明人： ZHU, Lingjian ,  HONG, Min ,  TAO, Weifeng ,  WU, Daize ,  PAN, Xiaoyu ,  GAO, Lu ,  HUANG, Jian

IPC分类号： C07D471/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00 ,  C07D239/00 ,  C07D241/36 ,  A61K31/50 ,  A61K31/495 ,  A61P31/18

CPC分类号： A61K31/495 ,  A61K31/50 ,  A61P31/18 ,  C07D239/00 ,  C07D241/36 ,  C07D471/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00

摘要： The present disclosure provides a pyridone compound having integrase inhibitory activity and a pharmaceutical use thereof. Specifically, the present disclosure provides a compound having a structure shown as formula I or a pharmaceutically acceptable salt thereof, which can be used to treat human immunodeficiency (HIV) infection.

公开(公告)号：EP4085059B1

公开(公告)日：2024-03-20

申请号：EP21736180.7

申请日：2021-01-04

发明人： MA, Haikuo ,  HE, Sudan ,  ZHANG, Xiaohu

IPC分类号： A61P35/00 ,  C07D495/04 ,  C07D519/00 ,  C07D417/12 ,  C07D495/10 ,  C07D495/20 ,  C07D497/10 ,  A61K31/428 ,  A61K31/4743

公开(公告)号：EP4305034A1

公开(公告)日：2024-01-17

申请号：EP23722475.3

申请日：2023-04-05

申请人： GILEAD SCIENCES, INC.

发明人： CHU, Hang ,  GONZALEZ BUENROSTRO, Ana Z. ,  HAN, Xiaochun ,  HURTLEY, Anna E. ,  JIANG, Lan ,  LI, Jiayao ,  SCHWARZWALDER, Gregg M. ,  SHIVAKUMAR, Devleena M. ,  VON BARGEN, Matthew J. ,  WU, Qiaoyin ,  YANG, Hong

IPC分类号： C07D471/22 ,  C07D491/22 ,  C07D497/22 ,  C07D498/22 ,  A61K31/55 ,  A61P31/18

公开(公告)号：EP4166539A1

公开(公告)日：2023-04-19

申请号：EP22198597.1

申请日：2021-08-06

申请人： Pfizer Inc.

发明人： OWEN, Dafydd Rhys ,  PETTERSSON, Martin Youngjin ,  REESE, Matthew Richard ,  SAMMONS, Matthew Forrest ,  TUTTLE, Jamison Bryce ,  VERHOEST, Patrick Robert ,  WEI, Liuqing ,  YANG, Qingyi ,  YANG, Xiaojing

IPC分类号： C07D207/267 ,  C07D403/12 ,  C07D403/14 ,  A61P31/14 ,  C07D401/12 ,  C07D497/04 ,  A61K31/4015 ,  A61K31/4025

摘要： The invention relates to the use as a medicament of a compound of formula Ih-1a, Ih-1b, Ih-1c, Ii-1a, Ii-1b, Ii-1c, Ij-1a, Ij-1b, Ij-1c, Ik-a, Ik-b or Ik-c:




wherein R 4 is defined herein; or a solvate or hydrate thereof, or a pharmaceutically acceptable salt of said compound, solvate or hydrate. These compounds are useful in treating coronavirus infections such as COVID-19.

公开(公告)号：EP3653615B1

公开(公告)日：2023-03-01

申请号：EP18831038.7

申请日：2018-07-11

发明人： MIYAZAKI Masayuki ,  TAKENAKA Junji

IPC分类号： C07D311/78 ,  C07D497/10 ,  C08G65/32 ,  C08K5/1545 ,  C08L101/00 ,  C09K9/02 ,  G02B1/04

公开(公告)号：EP3903778A1

公开(公告)日：2021-11-03

申请号：EP19901505.8

申请日：2019-12-30

申请人： Shanghai Archeus Biotech Co., Ltd.

发明人： GONG, Xiaoming

IPC分类号： A61K31/35 ,  A61K31/00 ,  A61K31/54 ,  A61P17/00 ,  A61K31/352 ,  C07D405/12 ,  C07D311/92 ,  C07D407/12 ,  C07D493/10 ,  C07D497/10

摘要： Provided are a drug, a pharmaceutical composition, or a pharmaceutical kit for immunosuppression, for the treatment of conditions such as psoriasis, comprising a forskolin derivative or a salt thereof and optionally a prostaglandin compound or a glucocorticoid compound. Further provided is a method for immunosuppression, comprising administration of a forskolin derivative or a salt thereof and optionally a prostaglandin compound or a glucocorticoid compound. Forskolin derivatives show promise as a class of small-molecule drugs for achieving immunosuppression using new mechanisms, for the treatment of conditions such as psoriasis, when used alone or in combination with other substances. Compared with first-line antibody drugs, forskolin derivatives have significant advantages in process and price, and have comparable efficacy and fewer side effects compared with the first-line drug calcipotriol betamethasone ointment.

公开(公告)号：EP3800185A1

公开(公告)日：2021-04-07

申请号：EP20208339.0

申请日：2015-03-19

申请人： FUJIFILM Corporation

发明人： Nakamura, Koki ,  Nagase, Hisato ,  Fujino, Yuuta ,  Watanabe, Katsuyuki ,  Katsumata, Taiji

IPC分类号： C07D319/06 ,  C07D333/32 ,  C07D409/06 ,  C07D493/04 ,  C07D497/10 ,  C07D333/46 ,  C07D497/04 ,  C07D317/30 ,  C07C69/734

摘要： An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group. A compound represented by Formula (1) is a compound useful for manufacturing salacinol.

(In the formula, each of R 1a and R 1b is a hydrogen atom or a hydroxy protective group; R 2 is a hydroxy group or the like; and R 3 is a hydroxy group or the like.)

公开(公告)号：EP3781570A1

公开(公告)日：2021-02-24

申请号：EP19887925.6

申请日：2019-11-20

申请人： Ascentage Pharma (Suzhou) Co., Ltd. ,  The Regents Of The University Of Michigan ,  Ascentage Pharma Group Corp Limited

发明人： CHEN, Hao ,  CHEN, Wenming ,  LI, Chao ,  LI, Dongbo ,  JING, Yu ,  TANG, Guozhi ,  ZHOU, Yunlong ,  WANG, Shaomeng ,  YANG, Chao-Yie

IPC分类号： C07D497/22 ,  C07D515/22 ,  C07D231/12 ,  A61K31/395 ,  A61P35/00