公开(公告)号：EP1629104A4

公开(公告)日：2006-11-02

申请号：EP04736153

申请日：2004-06-04

申请人： BIOLEADERS CORP ,  M D LAB ,  BIOLEADERS JAPAN CORP ,  KOREA RES INST OF BIOSCIENCE

发明人： SUNG MOON HEE ,  KIM CHUL JOONG ,  JUNG CHANG MIN ,  HONG SEUNG PYO ,  LEE JONG SU ,  CHOI JAE CHUL ,  KIM KWANG ,  SHUNICHI KURODA ,  POO HA RYOUNG

IPC分类号： C12N15/86 ,  A61K39/00 ,  C07K14/025 ,  C07K14/165 ,  C12N9/00 ,  C12N15/74

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/523 ,  C07K2319/00 ,  C12N9/93 ,  C12N15/74 ,  C12N2710/20022 ,  C12N2770/20022

摘要： The present invention relates to a surface expression vector of SARS coronavirus antigen containing a gene encoding an antigen of SARS inducing coronavirus and any one or two or more of genes pgsB, pgsC and pgsA encoding poly-gamma-glutamic acid synthase complex, a microorganism transformed by the surface expression vector, and a SARS vaccine comprising the microorganism. According to the present invention, it is possible to economically produce a vaccine for prevention and treatment of SARS using a recombinant strain expressing an SARS coronavirus antigen on their surface.

公开(公告)号：EP1945179A4

公开(公告)日：2015-01-21

申请号：EP05804510

申请日：2005-10-31

申请人： BIOLEADERS CORP

发明人： SUNG MOON HEE ,  PARK CHUNG ,  CHOI JAE CHUL ,  UYAMA HIROSHI ,  PARK SO LIM

IPC分类号： A61K8/88 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10

CPC分类号： A61Q19/08 ,  A61K8/88 ,  A61K2800/782 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/10

摘要： The present invention relates to a hyaluronidase inhibitor containing poly-gamma-glutamic acid (PGA) as an active ingredient, a composition for maintaining skin elasticity and a composition for improving allergy, wherein each of the compositions contains PGA as an active ingredient. The inventive compositions containing PGA are effective in maintaining skin moisturization and skin elasticity by effectively inhibiting the activity of hyaluronidase which is an enzyme that degrades hyaluronic acid present in the skin dermis. Also, the compositions can relieve allergic symptoms by inhibiting the permeability of inflammatory cells.

摘要翻译： 本发明涉及含有聚-γ-谷氨酸（PGA）作为活性成分的透明质酸酶抑制剂，用于保持皮肤弹性的组合物和用于改善过敏的组合物，其中每种组合物含有PGA作为活性成分。 含有PGA的本发明组合物通过有效抑制透明质酸酶的活性来有效地保持皮肤的保湿和皮肤弹性，透明质酸酶是降解皮肤真皮中存在的透明质酸的酶。 此外，组合物可以通过抑制炎症细胞的通透性来缓解过敏症状。