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1.发明公开Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications 审中-公开治疗维生素ALS HISTAMIN-H3-REZEPTOR LIGANDEN VON ALKYLAMINEN，DIE KEIN IMIDAZOLE ENTHALTEN
公开(公告)号：EP2000462A3
公开(公告)日：2011-05-04
申请号：EP06002726.5
申请日：1999-07-29
申请人： BIOPROJET
发明人： Schwartz, Jean-Charles , Arraang, Jean-Michel , Garbarg, Monique , Lecomte, Jeanne-Marie , Ligneau, Xavier , Schunack, Walter G. , Stark, Holger , Gannelin, Charon Robin , Leurquin, Fabien , Sigurd, Elz
IPC分类号： C07D295/088 , C07C211/08 , C07D211/04 , C07D295/185 , C07D211/62 , C07D211/70 , C07D207/20 , A61K31/13 , A61K31/40 , A61K31/445 , A61K31/495
CPC分类号： C07D213/74 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/55 , C07B2200/07 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
摘要： The present invention provides new non-imidazole alkylamine derivatives, and their use for preparing medicaments acting as ligands at the H 3 -receptors of histamine.
摘要翻译： 式（A）化合物：
其中：W是当在4（5）位上连接到咪唑环上时，组胺H 3受体具有拮抗作用和/或激动作用的残基。 R 1和R 2可以相同或不同，各自独立地表示低级烷基或环烷基，或与它们所连接的氮原子一起，含有如上定义的饱和含氮环（i）， 非限制性的非芳族不饱和含氮环（ii），吗啉代基或如所定义的N-取代哌嗪基。 化合物（A）可用于制备作为组胺H3受体的拮抗剂和/或激动剂的药物。 -
2.发明公开Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications 审中-公开烷基胺而无需咪唑环作为组胺H3拮抗剂和它们的治疗应用
公开(公告)号：EP0982300A2
公开(公告)日：2000-03-01
申请号：EP98403351.4
申请日：1998-12-31
发明人： Schwartz, Jean-Charles , Arrang, Jean-Michel , Garbarg, Monique , Lecomte, Jeanne-Marie , Ligneau, Xavier , Schunack, Walter G. , Stark, Holger , Ganellin, Charon Robin , Leurquin, Fabien , Sigurd, Elz
IPC分类号： C07D295/088 , C07C211/08 , C07D211/04 , C07D295/185 , C07D211/62 , C07D211/70 , C07D207/20 , A61P25/28
CPC分类号： C07D213/74 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/55 , C07B2200/07 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
摘要： Compounds of formula (A):
wherein:
― W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position.
― R 1 and R 2 may be identical or different and represent each independently
a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached,
a saturated nitrogen-containing ring (i) as defined,
a non-aromatic unsaturated nitrogen-containing ring (ii) as defined,
a morpholino group, or
a N-substituted piperazino group as defined.
Compounds (A) are useful for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.-
3.发明公开Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications 审中-公开治疗用途组胺H3受体配体烷基胺中不含咪唑
公开(公告)号：EP2000462A2
公开(公告)日：2008-12-10
申请号：EP06002726.5
申请日：1999-07-29
申请人： BIOPROJET
发明人： Schwartz, Jean-Charles , Arraang, Jean-Michel , Garbarg, Monique , Lecomte, Jeanne-Marie , Ligneau, Xavier , Schunack, Walter G. , Stark, Holger , Gannelin, Charon Robin , Leurquin, Fabien , Sigurd, Elz
IPC分类号： C07D211/22 , C07D207/08 , A61K31/445
CPC分类号： C07D213/74 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/55 , C07B2200/07 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
摘要： The present invention provides new non-imidazole alkylamine derivatives, and their use for preparing medicaments acting as ligands at the H 3 -receptors of histamine.
摘要翻译： 本发明提供了新的非咪唑烷基胺衍生物，以及它们用于制备药物的用途作为配位体在组胺H 3 - 受体拮抗剂。
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4.发明公开Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications 有权治疗药物Histamin-H3-Rezeptor Liganden von Alkylaminen，die kein咪唑酊剂
公开(公告)号：EP1428820A1
公开(公告)日：2004-06-16
申请号：EP04003944.8
申请日：1999-07-29
申请人： BIOPROJET
发明人： Schwartz, Jean-Charles , Arrang, Jean-Michel , Garbarg, Monique , Lecomte Jeanne-Marie , Ligneau, Xavier , Schunack, Walter G. , Stark, Holger , Ganellin, Charon Robin , Leurquin, Fabien , Sigurd, Elz
IPC分类号： C07D211/22 , C07D207/08 , A61K31/445 , A61K31/4453 , A61K31/401
CPC分类号： C07D213/74 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/55 , C07B2200/07 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
摘要： The present invention provides new non-imidazole alkylamine derivatives, and their use for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.
摘要翻译： 本发明提供了新的非咪唑烷基胺衍生物及其用于制备组胺的H3受体作为拮抗剂和/或激动剂的药物的用途。
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5.发明授权Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine 有权单盐酸盐1- [3- [3-（4-氯苯基）丙氧基]丙基] - 哌啶
公开(公告)号：EP1690858B1
公开(公告)日：2008-04-09
申请号：EP05100942.1
申请日：2005-02-10
申请人： BIOPROJET
发明人： Raga, Manuel , Sallares, Juan , Guerrero, Marta , Guglietta, Antonio , Schwartz, Jean-Charles , Lecomte, Jeanne-Marie , Schunack, Walter , Arrang, Jean-Michel , Ligneau, Xavier , Stark, Holger , Ganellin, Charon Robin
IPC分类号： C07D295/088 , A61K31/4453 , A61P25/28
CPC分类号： C07D295/088
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6.发明授权Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications 有权治疗药物Histamin-H3-Rezeptor Liganden von Alkylaminen，die kein咪唑酊剂
公开(公告)号：EP1428820B1
公开(公告)日：2006-05-17
申请号：EP04003944.8
申请日：1999-07-29
申请人： BIOPROJET
发明人： Schwartz, Jean-Charles , Arrang, Jean-Michel , Garbarg, Monique , Lecomte Jeanne-Marie , Ligneau, Xavier , Schunack, Walter G. , Stark, Holger , Ganellin, Charon Robin , Leurquin, Fabien , Sigurd, Elz
IPC分类号： C07D211/22 , C07D207/08 , A61K31/445 , A61K31/4453 , A61K31/401
CPC分类号： C07D213/74 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/55 , C07B2200/07 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
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7.发明公开Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications 审中-公开非咪唑烷基胺作为组胺H3受体配体及其治疗应用
公开(公告)号：EP0982300A3
公开(公告)日：2000-03-08
申请号：EP98403351.4
申请日：1998-12-31
发明人： Schwartz, Jean-Charles , Arrang, Jean-Michel , Garbarg, Monique , Lecomte, Jeanne-Marie , Ligneau, Xavier , Schunack, Walter G. , Stark, Holger , Ganellin, Charon Robin , Leurquin, Fabien , Sigurd, Elz
IPC分类号： C07D295/088 , C07C211/08 , C07D211/04 , C07D295/185 , C07D211/62 , C07D211/70 , C07D207/20 , A61P25/28
CPC分类号： C07D213/74 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/55 , C07B2200/07 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
摘要： Compounds of formula (A): wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position. R1 and R2 may be identical or different and represent each independentlya lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached,a saturated nitrogen-containing ring (i) as defined,a non-aromatic unsaturated nitrogen-containing ring (ii) as defined,a morpholino group, ora N-substituted piperazino group as defined. Compounds (A) are useful for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.
摘要翻译： 式（A）化合物：其中：W是当在4（5）位上连接到咪唑环时对组胺H 3受体赋予拮抗和/或激动活性的残基。 R 1和R 2可以相同或不同，并且各自独立地表示低级烷基或环烷基，或者与它们所连接的氮原子一起形成饱和含氮环（i），非芳族不饱和含氮环 如定义的环（ii），吗啉基或所定义的N-取代哌嗪基。 化合物（A）可用于制备充当组胺H3-受体拮抗剂和/或激动剂的药物。
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8.发明公开Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications 失效丙烯酰氧基 - （芳基硫基）烷基胺喔ne idaz ring ring s s ist ist che che che che che che che che che che che che ung ung
公开(公告)号：EP0978512A1
公开(公告)日：2000-02-09
申请号：EP98401944.8
申请日：1998-07-29
发明人： Schwartz, Jean-Charles , Arrang, Jean-Michel , Garbarg, Monique , Lecomte, Jeanne-Marie , Ligneau, Xavier , Schunack, Walter G. , Stark, Holger , Ganellin, Charon Robin , Leurquin, Fabien , Sigurd, Elz
IPC分类号： C07D295/088 , C07C211/08 , C07D211/04 , C07D295/185 , C07D211/62 , C07D211/70 , C07D207/20 , A61K31/13 , A61K31/40 , A61K31/445 , A61K31/495
CPC分类号： C07D213/74 , C07B2200/07 , C07C215/34 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
摘要： Compounds of formula (I):
and their use for preparing medicaments acting as antagonists at the H 3 -receptors of histamine.摘要翻译： 式（I）化合物：
及其在组胺H3受体上作为拮抗剂的药物的用途。
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