公开(公告)号：EP0391997A4

公开(公告)日：1992-01-15

申请号：EP89910995

申请日：1989-09-26

申请人： BIOTECHNOLOGY AUSTRALIA PTY. LTD. ,  COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION

发明人： DOPHEIDE, THEODORUS, ANTONIUS, ALOISIUS ,  FRENKEL, MAURICE, JOSEPH ,  GRANT, WARWICK, NORMAN ,  SAVIN, KEITH, WILLIAM ,  WAGLAND, BARRY, MAXWELL

IPC分类号： G01N33/569 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  C07K1/22 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/245 ,  C07K14/435 ,  C07K16/00 ,  C07K16/20 ,  C12N1/19 ,  C12N1/21 ,  C12N15/09 ,  C12P21/00 ,  C12R1/19 ,  C12R1/865 ,  C12N15/00 ,  C07H21/04 ,  C07K15/08 ,  C07K15/12 ,  C12N1/16 ,  C12N1/20 ,  C12P21/02 ,  C12Q1/68

CPC分类号： C07K16/20 ,  A61K38/00 ,  A61K39/00 ,  C07K14/245 ,  C07K14/4354 ,  C07K2319/00 ,  C07K2319/035 ,  C07K2319/40

摘要： The invention provides excretory/secretory antigens derived from parasitic nematode species which are capable of inducing protective immunity against infection by parasitic nematode species, and related antigenic molecules. The invention also provides nucleotide sequences encoding the antigens and related molecules of the invention, recombinant DNA molecules comprising the nucleotide sequences, and transformed hosts carrying the recombinant DNA molecules. The invention further provides antibodies against the antigens and related molecules, and antibody compositions comprising the antibodies, vaccines comprising the antigens and/or related molecules and methods of treating or preventing nematode infections using the antigens and related molecules, vaccines, antibodies and/or antibody compositions of the invention.

公开(公告)号：EP0330681A4

公开(公告)日：1991-11-21

申请号：EP88905625

申请日：1988-07-06

申请人： BIOTECHNOLOGY AUSTRALIA PTY. LTD. ,  COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

发明人： COBON, GARY, STEWART ,  AUSTEN, ROSEMARY, ANN ,  O'DONNELL, IAN, JOSEPH ,  FRENKEL, MAURICE, JOSEPH ,  KENNEDY, WILLIAM, PETER, KEITH ,  SAVIN, KEITH, WILLIAM ,  WAGLAND, BARRY, MAXWELL

IPC分类号： G01N33/569 ,  A61K39/00 ,  A61K39/395 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K16/00 ,  C07K16/18 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/577 ,  C07G17/00 ,  C07H21/04 ,  C07K13/00 ,  C07K15/12 ,  C12N1/20 ,  C12N15/00 ,  C12P19/34 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C07K14/4354 ,  A61K39/00 ,  A61K39/0003 ,  C07K16/18

摘要： A protein derived from a parasitic nematode such as T. colubriformis capable of conferring protective immunity against infection of a host by the nematode wherein said protein has an approximate molecular weight of 41kD as estimated by SDS-PAGE, or all, part, an analogue, homologue, derivative or combination thereof of said protein which is capable of conferring protective immunity against infection by the nematode.