公开(公告)号：EP3895890A1

公开(公告)日：2021-10-20

申请号：EP19895351.5

申请日：2019-12-09

申请人： BMG INCORPORATED

发明人： TANIDA, Shuhei ,  FUJIMURA, Motoki ,  KOJITANI, Yusuke ,  OSADA, Shinichi ,  HYON, Woogi ,  HYON, Suong-Hyu

IPC分类号： B32B27/00 ,  C08G81/00 ,  A61L15/26 ,  A61L15/28 ,  A61L15/32 ,  A61L15/42 ,  A61L15/44 ,  A61L15/58 ,  A61L15/64

摘要： A sheet-shaped tissue adhesive/reinforcement and its producing method in a manner as below, which realizes a good tissue reinforcing effect and handleability without the need to utilize fibrinogen and the blood coagulation ability derived from the patient being applied. The sheet-shaped tissue adhesive reinforcement comprises a base sheet having a biodegradability and communicative porous structure, and an adhesive resin layer fixed and formed on the base sheet. This adhesive resin layer comprises a first reactant comprising an aldehyded glycan and a second reactant comprising partially carboxylated polylysine, and has a granular structure derived from the powder of the first reactant and a connecting layer, which is derived from the second reactant and connects the granular structures to each other and fixes them to the base sheet. In a way to produce such reinforcement, a mixed powder of the first and second reactant is used. For example, this mixed powder is dispersed in ethanol having a water content of less than 1%, and the dispersion is applied onto the base sheet and then dried.