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1.发明公开
公开(公告)号：EP3676008A1
公开(公告)日：2020-07-08
申请号：EP18803523.2
申请日：2018-06-08
发明人： GENG, Yue , CAI, Peizhi , PANG, Fengchun , GU, Le , CHE, Chuncheng , XUE, Hailin , SHAO, Xibin
IPC分类号： B01L3/00
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公开(公告)号：EP3626811A1
公开(公告)日：2020-03-25
申请号：EP17892073.2
申请日：2017-12-15
发明人： PANG, Fengchun , CAI, Peizhi , GENG, Yue
摘要： A chip, a detection system and a gene sequencing method are provided. When the chip is used for gene sequencing, sample genes and reversible terminating nucleotides are added into micropores and matched therein to release hydrogen ions such that a Nernst potential is induced on an ion-sensitive film surface, and a voltage is applied to the transparent electrode layer to generate an electric field, thereby controlling the switching layer to change its state, and then a base type of the genes is determined based on a type of reversible terminating nucleotide corresponding to information of light emitted from the switching layer upon changes in the state of the switching layer, thereby gene sequencing is achieved. The chip has a simple structure and low fabrication cost, and the reversible terminating nucleotides for matching sequencing require no fluorescent labeling, and optical systems such as a backlight source and a laser light source are unnecessary, which greatly reduces the cost and time for gene sequencing.
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公开(公告)号：EP3885760A1
公开(公告)日：2021-09-29
申请号：EP19887902.5
申请日：2019-11-13
发明人： ZHAO, Yingying , CAI, Peizhi , GU, Le , PANG, Fengchun , GENG, Yue , XIAO, Yuelei , CUI, Haochen , ZHAO, Nan , LIAO, Hui , YAO, Wenliang , CHE, Chuncheng
摘要： The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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公开(公告)号：EP3735611A1
公开(公告)日：2020-11-11
申请号：EP18898879.4
申请日：2018-09-12
发明人： PANG, Fengchun , CAI, Peizhi , GENG, Yue , GU, Le , CHE, Chuncheng , XUE, Hailin , SHAO, Xibin
IPC分类号： G02F1/1343 , G02F1/133
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公开(公告)号：EP3950131A1
公开(公告)日：2022-02-09
申请号：EP19861238.4
申请日：2019-04-02
发明人： WU, Shenkang , HUANG, Dongsheng , DONG, Tingze , SHANG, Jianxing , LI, Yizhe , GENG, Yue , LI, Jian , CHEN, Guowei , XU, Hongliang , WANG, Kuohai , DAI, Chang , WEI, Na , LI, Xin , XIN, Xiao , SUN, Chao
IPC分类号： B01L3/00
摘要： A bio-information detection substrate and a gene chip are provided. The substrate includes a first main surface (111), the first main surface (111) includes a test region (102) and a dummy region (101) located around the test region (102), at least one accommodation region (12) is disposed on the first main surface (111), and the accommodation region (12) is located in the dummy region (101). During cell-assembling by using the substrate, the accommodation region (12) may used to eliminate an air bubble, thereby improving the yield of the product after cell-assembling.
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公开(公告)号：EP3623462A1
公开(公告)日：2020-03-18
申请号：EP18739446.5
申请日：2018-01-02
发明人： GENG, Yue , PANG, Fengchun , CAI, Peizhi , GU, Le
摘要： Embodiments of the disclosure provide a gene sequencing chip, including: an upper substrate including a plurality of liquid inlets for inletting liquid drops; a lower substrate opposite to the upper substrate and spaced therefrom by a gap, the gap being provided for allowing the liquid drops to move therein, the lower substrate including a liquid drop operation region, the liquid drop operation region including a manipulation electrode array. The manipulation electrode array includes multiple first sub-arrays for preparing a gene library, multiple second sub-arrays for sequencing the prepared gene library, each first sub-array being adjacent to one of the second sub-arrays. Based on the gene sequencing chip provided in this disclosure, operations to tiny liquid drops such as movement, fusion and splitting can be accurately manipulated by using digital microfluidic techniques, and all steps of the gene sequencing from library preparation to gene sequencing can be completed in a programmatic manner on one chip. The chip has a high degree of integration, the liquid drops can be manipulated accurately, the consumption of the reagents can be reduced, and the preparation process is simple and mature.
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7.发明公开
公开(公告)号：EP3561510A1
公开(公告)日：2019-10-30
申请号：EP17835577.2
申请日：2017-07-12
发明人： PANG, Fengchun , CAI, Peizhi , GENG, Yue
摘要： A detection substrate and a manufacturing method thereof, and a nucleic acid detecting method are provided. The detection substrate includes at least one detection unit (100) disposed on a base substrate (10), the detection unit (100) including a first electrode (11), a second electrode (13) and a colloid layer (17), the second electrode (13) disposed on a side of the first electrode (11) away from the base substrate (10), the second electrode (13) including at least one hollowed structure (1300), the second electrode (13) and the first electrode (11) being insulated from each other, and the first electrode (11) and the second electrode (13) being configured to be applied with voltages respectively; the colloid layer (17) at least disposed on the at least one hollowed structure (1300) of the second electrode (13), the colloid layer (17) including a linker (170) configured to be paired with a target nucleic acid (18). The detection substrate performs the amplification and detection of the nucleic acid by applying voltages to the first electrode (11) and the second electrode (13) of the detection unit (100) respectively. A requirement on the structure and appearance of the first electrode (11) and the second electrode (13) are simple, which simplifies the process difficulty.
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公开(公告)号：EP4145341A1
公开(公告)日：2023-03-08
申请号：EP20963082.1
申请日：2020-11-30
发明人： FENG, Yajie , LI, Cheng , GENG, Yue , WANG, Kuiyuan , LI, Zefei , QI, Chaoyang , DAI, Yi , LI, Xiaoguan , WANG, Yingzi
IPC分类号： G06K9/00 , H01L31/0216
摘要： An optical sensor array substrate and an optical fingerprint reader are provided. The optical sensor array substrate (30) includes a substrate (31) including a detection area (30A) and a peripheral area (30R) surrounding the detection area (30A), wherein, the detection area (30A) includes a plurality of photosensitive pixels (30a), at least one of which includes: a thin film transistor (32) arranged on the substrate (31) and having a gate (32a), an active layer (32b), a source (32c) and a drain (32d); a storage capacitor (33) arranged on the substrate (31) and having a first capacitor plate (33a) and a second capacitor plate (33b), wherein the second capacitor plate (33b) is located on one side of the first capacitor plate (33a) away from the substrate (31), and electrically connected to the source (32c) or drain (32d) of the thin film transistor (32); a photosensitive element (39) located on one side of the storage capacitor (33) away from the substrate (31), and having one end electrically connected to the second capacitor plate (33b); a first electrode layer (36a) located on one side of the photosensitive element (39) away from the substrate (31) and electrically connected to another end of the photosensitive element (39), wherein an orthographic projection of the second capacitor plate (33b) on the substrate (31) at least partially overlaps with an orthographic projection of the first electrode layer (36a) on the substrate.
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公开(公告)号：EP4206980A1
公开(公告)日：2023-07-05
申请号：EP21942294.6
申请日：2021-05-26
发明人： FENG, Yajie , LI, Cheng , GENG, Yue , WANG, Kuiyuan , LI, Zhonghuan , DAI, Yi , QI, Chaoyang , LI, Zefei , XI, Congcong , LI, Xiaoguan
IPC分类号： G06K9/00
摘要： Provided in the present disclosure are a ridge recognition substrate and a ridge recognition apparatus. The ridge recognition substrate comprises: a base substrate, which comprises a photosensitive area and a light-shielding area, which is located on at least one side of the photosensitive area; a plurality of photosensitive devices, which are arranged in the photosensitive area in an array, wherein the photosensitive devices each comprise a first electrode, a photoelectric conversion structure and a second electrode, which are arranged in a stacked manner, the photoelectric conversion structure being electrically connected to the first electrode, and the photoelectric conversion structure being in direct contact with the second electrode; and a plurality of virtual devices, which are arranged in the light-shielding area in an array, wherein the virtual devices each comprise a third electrode, an equivalent dielectric layer and a fourth electrode, the third electrode and the first electrode being in the same layer, the fourth electrode being located on the side of the layer, where the second electrode is located, that faces away from the base substrate, and the equivalent dielectric layer being located between the layer where the third electrode is located and the layer where the fourth electrode is located; and the virtual devices are configured to not perform photoelectric conversion.
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公开(公告)号：EP4206981A1
公开(公告)日：2023-07-05
申请号：EP21943555.9
申请日：2021-06-03
发明人： FENG, Yajie , LI, Cheng , GENG, Yue , WANG, Kuiyuan , LI, Zhonghuan , DAI, Yi , QI, Chaoyang , LI, Zefei , LI, Xiaoguan , XI, Congcong
IPC分类号： G06K9/00
摘要： The present invention provides a print identification substrate and a print identification apparatus. The print identification substrate comprises a base substrate, which comprises data lines and gate lines crossing each other; a light shielding structure, located on the base substrate, and comprising at least one metal layer, wherein an orthographic projection of the light shielding structure on the base substrate and orthographic projections of the data lines and the gate lines on the base substrate do not overlap each other; a photoelectric conversion structure, located on the side of the light shielding structure away from the base substrate, an orthographic projection of the photoelectric conversion structure on the base substrate being located in an orthographic projection of the light shielding structure on the base substrate, and a distance between an edge of the photoelectric conversion structure and an edge of the light shielding structure being less than or equal to 3 µm.
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